WormBase Tree Display for Gene: WBGene00004860
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| WBGene00004860 | SMap | S_parent | Sequence | C32D5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sma-6 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C32D5.2 | ||||||||
| Molecular_name | C32D5.2 | ||||||||
| C32D5.2.1 | |||||||||
| CE01842 | |||||||||
| Other_name | CELE_C32D5.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | sma-6 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sma | ||||||||
| Reference_allele | WBVar00144032 | ||||||||
| Allele (41) | |||||||||
| Legacy_information | e1482 : short adult and late larvae. ES2 ME3. NA1. | ||||||||
| [C.elegansII] e1482 : short adult and late larvae. e1482/Df similar. ES2 ME3. NA1. [CB] | |||||||||
| Strain | WBStrain00023046 | ||||||||
| WBStrain00003052 | |||||||||
| WBStrain00026327 | |||||||||
| WBStrain00026347 | |||||||||
| WBStrain00030738 | |||||||||
| WBStrain00037158 | |||||||||
| WBStrain00004344 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00000897 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000900 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sma-6 encodes a serine/threonine protein kinase that is orthologous to type I TGF-beta receptors; sma-6 activity is required for regulating body length and for proper development of the male tail; sma-6, along with other genes in the TGF-beta Sma/Mab pathway, also regulates reproductive aging; a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-6 expression first begins at the 1.5-fold stage of embryogenesis and continues through adulthood; sma-6 is expressed in dorsal and ventral hypodermis, pharyngeal muscle, and the intestine; expression in the hypodermis is necessary and sufficient for body length regulation. | Paper_evidence | WBPaper00003400 | |||||
| WBPaper00005021 | |||||||||
| WBPaper00035556 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 14 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables BMP binding activity. Involved in several processes, including defense response to other organism; nematode male tail tip morphogenesis; and positive regulation of nitrogen compound metabolic process. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in ASI; hypodermis; intestinal cell; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); carcinoma (multiple); and glaucoma (multiple). Is an ortholog of human BMPR1B (bone morphogenetic protein receptor type 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (26) | ||||||||
| Molecular_info | Corresponding_CDS | C32D5.2 | |||||||
| Corresponding_transcript | C32D5.2.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf221420 | ||||||||
| WBsf221421 | |||||||||
| WBsf221422 | |||||||||
| Experimental_info (8) | |||||||||
| Map_info | Map | II | Position | -0.382096 | Error | 0.000481 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C32D5 | Person_evidence | WBPerson465 | |||||
| Author_evidence | Krishna S | ||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Outside_rearr | mDf14 | |||||||
| Mapping_data | 2_point | 1534 | |||||||
| 3709 | |||||||||
| Multi_point | 843 | ||||||||
| 1360 | |||||||||
| 1719 | |||||||||
| 3796 | |||||||||
| 5272 | |||||||||
| Pos_neg_data | 3710 | ||||||||
| 3711 | |||||||||
| 3712 | |||||||||
| 3713 | |||||||||
| 3714 | |||||||||
| 10459 | |||||||||
| Reference (147) | |||||||||
| Picture | WBPicture0000013077 | ||||||||
| Method | Gene |
