WormBase Tree Display for Gene: WBGene00002994
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WBGene00002994 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T09A5 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lin | ||||||
Reference_allele | WBVar00143936 | ||||||
Allele (47) | |||||||
Possibly_affected_by | WBVar02153207 | ||||||
Legacy_information | See also e1348, e1457 | ||||||
[C.elegansII] e1348 : thin, sterile and uncoordinated after L1; all postembryonic divisions fail from defective cytokinesis although DNA replication continues. No sexual maturation in either sex. ES3 ME0. OA1: e1457 (similar phenotypes). Cloned: cosmid rescue (C03G3)[Sulston and Horvitz 1981; Albertson et al. 1978; MT] | |||||||
Strain | WBStrain00034590 | ||||||
WBStrain00034592 | |||||||
WBStrain00034597 | |||||||
WBStrain00034598 | |||||||
WBStrain00034599 | |||||||
WBStrain00004404 | |||||||
WBStrain00024322 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (33) | |||||||
Ortholog (30) | |||||||
Paralog | WBGene00008508 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | lin-5 encodes a novel protein with a centrally located alpha-helical coiled-coil domain and ten potential proline-directed kinase phosphorylation sites; LIN-5 activity is required for mitosis and cytokinesis at all stages of development and specifically, for spindle positioning, chromosome alignment and segregation, and perhaps also for blocking exit from mitosis when chromosome segregation fails; LIN-5, which is expressed maternally, embryonically, and during larval stages, localizes to the cell periphery and, in a microtubule-dependent manner, to the meiotic spindle and the asters and kinetochore microtubules of the mitotic spindle; in regulating spindle function, LIN-5 interacts with two G protein regulators, GPR-1 and GPR-2, which require LIN-5 activity for localization to the spindle and cell cortex; additionally, LIN-5 interacts in vitro with itself, the coiled-coil protein LFI-1, GEI-16, and several other novel proteins; genetic studies indicate that in regulating embryonic spindle function, lin-5 acts downsteam of par-2, par-3, mes-1, and src-1 and upstream of gpr-1, gpr-2, goa-1, and gpa-16. | Paper_evidence | WBPaper00000496 | |||
WBPaper00003888 | |||||||
WBPaper00005878 | |||||||
WBPaper00024244 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 31 Jan 2006 00:00:00 | ||||||
Automated_description | Enables dynein complex binding activity. Involved in several processes, including gonad development; microtubule cytoskeleton organization; and regulation of protein localization. Located in cell cortex; condensed chromosome; and spindle. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T09A5.10 | |||||
Corresponding_transcript | T09A5.10.1 | ||||||
T09A5.10.2 | |||||||
Other_sequence | AF240692 | ||||||
CJC05213_1 | |||||||
CJC04398_1 | |||||||
Associated_feature | WBsf644424 | ||||||
WBsf644425 | |||||||
WBsf657896 | |||||||
WBsf657897 | |||||||
WBsf221650 | |||||||
WBsf221651 | |||||||
Experimental_info | RNAi_result (25) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00008070 | ||||||
WBCnstr00036299 | |||||||
Construct_product | WBCnstr00008969 | ||||||
WBCnstr00008970 | |||||||
WBCnstr00008971 | |||||||
WBCnstr00008972 | |||||||
WBCnstr00008973 | |||||||
WBCnstr00008974 | |||||||
WBCnstr00008975 | |||||||
WBCnstr00008976 | |||||||
WBCnstr00036299 | |||||||
Antibody | WBAntibody00000263 | ||||||
WBAntibody00000264 | |||||||
WBAntibody00000265 | |||||||
WBAntibody00001313 | |||||||
WBAntibody00001371 | |||||||
WBAntibody00001496 | |||||||
WBAntibody00001497 | |||||||
WBAntibody00002113 | |||||||
WBAntibody00002288 | |||||||
Microarray_results (23) | |||||||
Expression_cluster (148) | |||||||
Interaction (196) | |||||||
WBProcess | WBbiopr:00000017 | ||||||
Map_info | Map | II | Position | 0.586677 | Error | 0.000809 | |
Well_ordered | |||||||
Positive | Positive_clone | C03G3 | |||||
T09A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Outside_rearr | mcDf1 | |||||
Mapping_data | Multi_point | 50 | |||||
705 | |||||||
711 | |||||||
4611 | |||||||
Pos_neg_data | 1359 | ||||||
1391 | |||||||
1465 | |||||||
1473 | |||||||
1480 | |||||||
1484 | |||||||
1497 | |||||||
1505 | |||||||
1509 | |||||||
8959 | |||||||
Reference (104) | |||||||
Remark | Sequence connection from [Lorson MA, van den Heuvel S] | ||||||
Method | Gene |