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WormBase Tree Display for Gene: WBGene00002994

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Name Class

WBGene00002994EvidenceCGC_data_submission
SMapS_parentSequenceT09A5
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classlin
Reference_alleleWBVar00143936
Allele (47)
Possibly_affected_byWBVar02153207
Legacy_informationSee also e1348, e1457
[C.elegansII] e1348 : thin, sterile and uncoordinated after L1; all postembryonic divisions fail from defective cytokinesis although DNA replication continues. No sexual maturation in either sex. ES3 ME0. OA1: e1457 (similar phenotypes). Cloned: cosmid rescue (C03G3)[Sulston and Horvitz 1981; Albertson et al. 1978; MT]
StrainWBStrain00034590
WBStrain00034592
WBStrain00034597
WBStrain00034598
WBStrain00034599
WBStrain00004404
WBStrain00024322
RNASeq_FPKM (74)
GO_annotation (33)
Ortholog (30)
ParalogWBGene00008508Caenorhabditis elegansFrom_analysisInparanoid_8
WormBase-Compara
Structured_descriptionConcise_descriptionlin-5 encodes a novel protein with a centrally located alpha-helical coiled-coil domain and ten potential proline-directed kinase phosphorylation sites; LIN-5 activity is required for mitosis and cytokinesis at all stages of development and specifically, for spindle positioning, chromosome alignment and segregation, and perhaps also for blocking exit from mitosis when chromosome segregation fails; LIN-5, which is expressed maternally, embryonically, and during larval stages, localizes to the cell periphery and, in a microtubule-dependent manner, to the meiotic spindle and the asters and kinetochore microtubules of the mitotic spindle; in regulating spindle function, LIN-5 interacts with two G protein regulators, GPR-1 and GPR-2, which require LIN-5 activity for localization to the spindle and cell cortex; additionally, LIN-5 interacts in vitro with itself, the coiled-coil protein LFI-1, GEI-16, and several other novel proteins; genetic studies indicate that in regulating embryonic spindle function, lin-5 acts downsteam of par-2, par-3, mes-1, and src-1 and upstream of gpr-1, gpr-2, goa-1, and gpa-16.Paper_evidenceWBPaper00000496
WBPaper00003888
WBPaper00005878
WBPaper00024244
Curator_confirmedWBPerson1843
Date_last_updated31 Jan 2006 00:00:00
Automated_descriptionEnables dynein complex binding activity. Involved in several processes, including gonad development; microtubule cytoskeleton organization; and regulation of protein localization. Located in cell cortex; condensed chromosome; and spindle.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST09A5.10
Corresponding_transcriptT09A5.10.1
T09A5.10.2
Other_sequenceAF240692
CJC05213_1
CJC04398_1
Associated_featureWBsf644424
WBsf644425
WBsf657896
WBsf657897
WBsf221650
WBsf221651
Experimental_infoRNAi_result (25)
Expr_pattern (11)
Drives_constructWBCnstr00008070
WBCnstr00036299
Construct_productWBCnstr00008969
WBCnstr00008970
WBCnstr00008971
WBCnstr00008972
WBCnstr00008973
WBCnstr00008974
WBCnstr00008975
WBCnstr00008976
WBCnstr00036299
AntibodyWBAntibody00000263
WBAntibody00000264
WBAntibody00000265
WBAntibody00001313
WBAntibody00001371
WBAntibody00001496
WBAntibody00001497
WBAntibody00002113
WBAntibody00002288
Microarray_results (23)
Expression_cluster (148)
Interaction (196)
WBProcessWBbiopr:00000017
Map_infoMapIIPosition0.586677Error0.000809
Well_ordered
PositivePositive_cloneC03G3
T09A5Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrmcDf1
Mapping_dataMulti_point50
705
711
4611
Pos_neg_data1359
1391
1465
1473
1480
1484
1497
1505
1509
8959
Reference (104)
RemarkSequence connection from [Lorson MA, van den Heuvel S]
MethodGene