WormBase Tree Display for Gene: WBGene00001862
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| WBGene00001862 | SMap | S_parent | Sequence | ZK381 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | him-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK381.1 | ||||||||
| Molecular_name | ZK381.1a | ||||||||
| ZK381.1a.1 | |||||||||
| CE07625 | |||||||||
| ZK381.1b | |||||||||
| Other_name | CELE_ZK381.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | him-3 | ||||||||
| DB_info | Database | AceView | gene | 4H743 | |||||
| WormQTL | gene | WBGene00001862 | |||||||
| WormFlux | gene | WBGene00001862 | |||||||
| NDB | locus_tag | CELE_ZK381.1 | |||||||
| NCBI | gene | 177462 | |||||||
| RefSeq | protein | NR_131562.1 | |||||||
| NM_068677.7 | |||||||||
| TrEMBL | UniProtAcc | G5EBG0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBG0 | |||||||
| RNAcentral | URSid | URS00002EBB46 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | him | ||||||||
| Reference_allele | WBVar00143776 | ||||||||
| Allele (19) | |||||||||
| Legacy_information | e1147 : self-progeny 3.5% XO male 2% ova are nullo-X. ES2 (progeny). ME3. NA2 (e1256 stronger allele : 11% Him many unhatched eggs (71%) males sire inviable zygotes probably generalized meiotic nondisjunction). | ||||||||
| See also e1147, e1256 | |||||||||
| [C.elegansII] e1147 : self-progeny 3.5% XO male 2% ova are nullo-X. ES2 (progeny). ME3. OA1: e1256 (stronger allele, 11% Him many unhatched eggs (71%); males sire inviable zygotes; probably generalized meiotic nondisjunction; some reduction in autosomal recombination, effects on segregation of free duplications). [Hodgkin et al. 1979; KR] | |||||||||
| Strain (87) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00002032 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00002033 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes. | Paper_evidence | WBPaper00000179 | |||||
| WBPaper00003675 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jan 2005 00:00:00 | ||||||||
| Automated_description | Enables DNA binding activity. Involved in regulation of centriole-centriole cohesion and synaptonemal complex assembly. Located in lateral element. Expressed in oocyte and spermatocyte. Is an ortholog of human HORMAD1 (HORMA domain containing 1) and HORMAD2 (HORMA domain containing 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK381.1a | |||||||
| Corresponding_transcript | ZK381.1b | ||||||||
| ZK381.1a.1 | |||||||||
| Other_sequence | CBC00259_1 | ||||||||
| Associated_feature | WBsf228485 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1163 | ||||||||
| Expr12535 | |||||||||
| Expr1011806 | |||||||||
| Expr1031095 | |||||||||
| Expr1162817 | |||||||||
| Expr2012428 | |||||||||
| Expr2030664 | |||||||||
| Drives_construct | WBCnstr00005293 | ||||||||
| WBCnstr00036642 | |||||||||
| Construct_product | WBCnstr00005240 | ||||||||
| WBCnstr00006069 | |||||||||
| WBCnstr00007210 | |||||||||
| WBCnstr00021221 | |||||||||
| WBCnstr00021222 | |||||||||
| WBCnstr00036642 | |||||||||
| Antibody | WBAntibody00000238 | ||||||||
| WBAntibody00000824 | |||||||||
| WBAntibody00000995 | |||||||||
| WBAntibody00001653 | |||||||||
| WBAntibody00002437 | |||||||||
| WBAntibody00002942 | |||||||||
| WBAntibody00003002 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (358) | |||||||||
| Map_info | Map | IV | Position | 3.27333 | Error | 0.002452 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK381 | Person_evidence | WBPerson715 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point (3) | ||||||||
| Pos_neg_data | 5437 | ||||||||
| 5438 | |||||||||
| 5439 | |||||||||
| 5440 | |||||||||
| 5441 | |||||||||
| 5442 | |||||||||
| 5443 | |||||||||
| Reference (105) | |||||||||
| Method | Gene |
