WormBase Tree Display for Gene: WBGene00001833
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| WBGene00001833 | SMap | S_parent | Sequence | Y110A7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | hcp-6 | Person_evidence | WBPerson537 | |||||
| Sequence_name | Y110A7A.1 | ||||||||
| Molecular_name | Y110A7A.1a | ||||||||
| Y110A7A.1a.1 | |||||||||
| CE24117 | |||||||||
| Y110A7A.1b | |||||||||
| CE28104 | |||||||||
| Y110A7A.1b.1 | |||||||||
| Other_name | let-108 | Person_evidence | WBPerson533 | ||||||
| let-594 | Person_evidence | WBPerson533 | |||||||
| CELE_Y110A7A.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | hcp-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 Mar 2015 11:59:07 | WBPerson2970 | Event | Acquires_merge | WBGene00002377 | ||||
| Name_change | Other_name | let-108 | |||||||
| 3 | 05 Mar 2015 12:05:21 | WBPerson2970 | Event | Acquires_merge | WBGene00002772 | ||||
| Name_change | Other_name | let-594 | |||||||
| Acquires_merge | WBGene00002377 | ||||||||
| WBGene00002772 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hcp | ||||||||
| Allele (68) | |||||||||
| Legacy_information | [Johnsen RC, Rose AM ] Mid-larval lethal both alleles similar | ||||||||
| [Johnsen RC, Rose AM ] Late larval lethal; both alleles similar | |||||||||
| Complementation_data | [Johnsen RC, Rose AM ] Complements let-101(h242), let-102(h188), let-103(h420), let-104(h799), let-105(h681), let-106(h787), let-107(h758), let-109(h811), let-110(h827), let-352(h45), let-596(h782), let-599(h290), let-612(h466), let-618(h272) | ||||||||
| [Johnsen RC, Rose AM ] complements let-111(h205), let-112(h691), let-113(h739), let-370(h128), let-598(h213) | |||||||||
| Strain | WBStrain00000213 | ||||||||
| WBStrain00000214 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001087 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hcp-6 encodes a HEAT motif-containing protein that displays similarity to the XCAP-D2/CNAP1/Cnd1/YCS4 family of proteins that are homologous to the condensin complex subunit 1; HCP-6 activity is required during mitosis for some aspects of mitotic chromosome condensation, attachment of microtubules to kinetochores, mitotic chromosome alignment, and mitotic sister chromatid segregation; during interphase, HCP-6 is detectable in a punctate pattern in the nucleoplasm; at prophase, HCP-6 becomes associated with condensed chromosomes, colocalizing with the centromeric component HCP-3; HCP-6 localization to chromosomes depends upon the activity of HCP-3 and HCP-4, a C. elegans CENP-C-like protein. | Paper_evidence | WBPaper00005322 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Mar 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable histone binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; embryo development; and mitotic chromosome condensation. Located in condensed chromosome, centromeric region and nucleoplasm. Part of condensin complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is an ortholog of human NCAPD3 (non-SMC condensin II complex subunit D3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28952) | ||||
| Molecular_info | Corresponding_CDS | Y110A7A.1a | |||||||
| Y110A7A.1b | |||||||||
| Corresponding_transcript | Y110A7A.1a.1 | ||||||||
| Y110A7A.1b.1 | |||||||||
| Other_sequence | Oden_isotig24618 | ||||||||
| HG01686 | |||||||||
| CRC11767_1 | |||||||||
| EX548161.1 | |||||||||
| ACC38375_1 | |||||||||
| HGC02165_1 | |||||||||
| Associated_feature | WBsf643279 | ||||||||
| WBsf656293 | |||||||||
| WBsf656294 | |||||||||
| WBsf656295 | |||||||||
| WBsf656296 | |||||||||
| WBsf656297 | |||||||||
| WBsf217632 | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr1925 | ||||||||
| Expr9851 | |||||||||
| Expr1019090 | |||||||||
| Expr1031078 | |||||||||
| Expr1158850 | |||||||||
| Expr2012381 | |||||||||
| Expr2030617 | |||||||||
| Drives_construct | WBCnstr00036658 | ||||||||
| Construct_product | WBCnstr00036658 | ||||||||
| Antibody | WBAntibody00000529 | ||||||||
| WBAntibody00000813 | |||||||||
| WBAntibody00000814 | |||||||||
| WBAntibody00002020 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (20) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | I | Position | -0.329448 | Error | 0.00309 | |||
| Hide_under | WBGene00003792 | ||||||||
| WBGene00002380 | |||||||||
| Positive | Inside_rearr (5) | ||||||||
| Positive_clone | Y110A7 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Y110A7A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | hDp22 | |||||||
| Mapping_data | Multi_point | 4035 | |||||||
| 5439 | |||||||||
| Pos_neg_data | 9747 | ||||||||
| 9748 | |||||||||
| 9910 | |||||||||
| 9911 | |||||||||
| 9912 | |||||||||
| 9913 | |||||||||
| Reference (24) | |||||||||
| Remark | Gene name created on basis of pubmed 12080088 [krb 020719] | ||||||||
| Postive_clone, Description and Allele (mr17) data extracted from Stear JH, and Roth MB (2002) [ck1 020828] | |||||||||
| Positive_clone is based on transgenic rescue [030403 ck1] | |||||||||
| Method | Gene |
