WormBase Tree Display for Gene: WBGene00000936
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| WBGene00000936 | SMap | S_parent | Sequence | T25F10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dbl-1 | Person_evidence | WBPerson698 | |||||
| Sequence_name | T25F10.2 | ||||||||
| Molecular_name | T25F10.2 | ||||||||
| T25F10.2.1 | |||||||||
| CE26386 | |||||||||
| Other_name | cet-1 | ||||||||
| CELE_T25F10.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | dbl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dbl | ||||||||
| Allele (52) | |||||||||
| Legacy_information | [Suzuki Y] dbl for decapentaplegic, bone morphogenetic protein 2,4-like. ev580 is a Tc1 insertion allele. Sma. Fused rays and crumpled spicules in male. | ||||||||
| Complementation_data | [Suzuki Y] complements let-410(s815), let-469(s1582), let-471(s1570), let-472(s1605) | ||||||||
| Strain | WBStrain00004001 | ||||||||
| WBStrain00005163 | |||||||||
| WBStrain00026325 | |||||||||
| WBStrain00026349 | |||||||||
| WBStrain00029114 | |||||||||
| WBStrain00030745 | |||||||||
| WBStrain00037644 | |||||||||
| WBStrain00007207 | |||||||||
| WBStrain00007209 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (43) | |||||||||
| Ortholog (55) | |||||||||
| Paralog | WBGene00000903 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006852 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006570 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021594 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dbl-1 encodes a member of the transforming growth factor beta (TGFbeta) superfamily that includes Drosophila decapentaplegic (Dpp) and the vertebrate bone morphogenetic proteins (BMPs); DBL-1 functions as a dose-dependent ligand for the SMA-6 and DAF-4 TGFbeta receptors that ultimately activate the SMA-2, -3, and -4 complex of transcription factors to regulate body length and size, as well as the patterning of male sensory rays and copulatory spicules; DBL-1 signaling upregulates sma-6 expression, suggesting that there is positive autoregulation in the DBL-1 signaling pathway; in contrast, DBL-1 negatively regulates expression of LON-1, a predicted secreted protein that is a downstream component of the body size pathway; in addition to its other roles, the TGFbeta Sma/Mab pathway also regulates reproductive aging, mutants of the pathway show an extension of the reproductive span, independent of somatic longevity; DBL-1 is expressed primarily in neurons. | Paper_evidence | WBPaper00003401 | |||||
| WBPaper00003454 | |||||||||
| WBPaper00003859 | |||||||||
| WBPaper00005325 | |||||||||
| WBPaper00035556 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including defense response to other organism; positive regulation of macromolecule metabolic process; and regulation of developmental process. Predicted to be located in extracellular space. Expressed in body wall musculature; nervous system; pm2 precursor; and in male. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); carcinoma (multiple); and eye disease (multiple). Is an ortholog of human BMP7 (bone morphogenetic protein 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14323 | Homo sapiens | Paper_evidence | WBPaper00046710 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Sep 2015 00:00:00 | ||||||||
| Potential_model (32) | |||||||||
| Models_disease_in_annotation | WBDOannot00000380 | ||||||||
| Molecular_info | Corresponding_CDS | T25F10.2 | |||||||
| Corresponding_transcript | T25F10.2.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product (14) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (260) | |||||||||
| Anatomy_function | WBbtf0608 | ||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000025 | |||||||||
| WBbiopr:00000026 | |||||||||
| WBbiopr:00000033 | |||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | V | Position | 0.136803 | Error | 0.002017 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf20 | |||||||
| nDf32 | |||||||||
| Positive_clone | T25F10 | Person_evidence | WBPerson2349 | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| ZC421 | |||||||||
| Negative | Outside_rearr | nDf18 | |||||||
| Mapping_data | Multi_point | 3551 | |||||||
| 4923 | |||||||||
| 5058 | |||||||||
| Pos_neg_data (3) | |||||||||
| Reference (276) | |||||||||
| Picture | WBPicture0000013077 | ||||||||
| Method | Gene |
