WormBase Tree Display for Gene: WBGene00000899
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WBGene00000899 | SMap | S_parent | Sequence | F25E2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | daf | ||||||
Reference_allele | WBVar00143953 | ||||||
Allele (178) | |||||||
Legacy_information | e1376 : defective dauer formation (daf-2 suppressible). ES1 ME3 NA8. | ||||||
See also e1376 | |||||||
[C.elegansII] e1376 : defective dauer formation. ES1 ME3. OA7. [Riddle et al. 1981; Thomas et al. 1993; DR] | |||||||
Strain (14) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Ortholog (26) | |||||||
Paralog | WBGene00004857 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
WBGene00004856 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
WBGene00000904 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
WBGene00000910 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
WBGene00004858 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006445 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | daf-3 encodes a co-SMAD protein that is most closely related to Drosophila Medea and the vertebrate Smad4 proteins; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage as well as for regulation of pharyngeal gene expression during non-dauer development, and normal adult lifespan; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; in vitro, DAF-3 binds the organ-specific C subelement in the promoter of the pharyngeal muscle-specific myosin myo-2 and in vivo, suppresses the enhancer activity of this element during larval development; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development, including the gut, nervous system and pharynx; DAF-3 localizes predominantly to the cytoplasm, but is also found in the nucleus in association with mitotic chromosomes. | Paper_evidence | WBPaper00002915 | |||
WBPaper00003384 | |||||||
WBPaper00006332 | |||||||
WBPaper00031040 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 10 Apr 2017 00:00:00 | ||||||
Automated_description | Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of dauer larval development; and regulation of pharyngeal pumping. Located in condensed chromosome; cytoplasm; and nucleus. Expressed in several structures, including P1; P2; hermaphrodite distal tip cell; hypodermal cell; and neurons. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F25E2.5a | |||||
F25E2.5b | |||||||
F25E2.5c | |||||||
F25E2.5d | |||||||
F25E2.5e | |||||||
F25E2.5f | |||||||
F25E2.5g | |||||||
F25E2.5h | |||||||
F25E2.5i | |||||||
Corresponding_transcript | F25E2.5a.1 | ||||||
F25E2.5b.1 | |||||||
F25E2.5c.1 | |||||||
F25E2.5d.1 | |||||||
F25E2.5e.1 | |||||||
F25E2.5f.1 | |||||||
F25E2.5g.1 | |||||||
F25E2.5h.1 | |||||||
F25E2.5i.1 | |||||||
Other_sequence | CBC08439_1 | ||||||
Associated_feature | WBsf653668 | ||||||
WBsf669931 | |||||||
WBsf670084 | |||||||
WBsf978813 | |||||||
WBsf1003871 | |||||||
WBsf1003872 | |||||||
WBsf1022176 | |||||||
WBsf236964 | |||||||
WBsf236965 | |||||||
Gene_product_binds | WBsf919607 | ||||||
WBsf919641 | |||||||
Transcription_factor | WBTranscriptionFactor000472 | ||||||
Experimental_info (11) | |||||||
Map_info | Map | X | Position | -19.4994 | Error | 0.004628 | |
Well_ordered | |||||||
Positive | Inside_rearr | mgDf90 | |||||
Positive_clone | F25E2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | 2_point | 299 | |||||
413 | |||||||
414 | |||||||
Multi_point | 5067 | ||||||
Pos_neg_data | 9317 | ||||||
Reference (225) | |||||||
Method | Gene |