WormBase Tree Display for Gene: WBGene00000296
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| WBGene00000296 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | B0432 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cat-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | B0432.5 | ||||||||
| Molecular_name | B0432.5a | ||||||||
| B0432.5a.1 | |||||||||
| CE29946 | |||||||||
| B0432.5b | |||||||||
| CE37742 | |||||||||
| B0432.5c | |||||||||
| CE45548 | |||||||||
| B0432.5b.1 | |||||||||
| B0432.5c.1 | |||||||||
| Other_name | CELE_B0432.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cat-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cat | ||||||||
| Reference_allele | WBVar00143753 | ||||||||
| Allele (50) | |||||||||
| Legacy_information | e1112 : dopamine reduced > 95%; serotonin normal. ES1 ME3 NA1. | ||||||||
| See also e1112 | |||||||||
| [C.elegansII] e1112 : dopamine reduced > 95%; serotonin normal; no defect in male turning behavior. ES1 ME3 NA1. [Sulston et al. 1975, Loer and Kenyon 1993; LC] | |||||||||
| Strain | WBStrain00027527 | ||||||||
| WBStrain00034688 | |||||||||
| WBStrain00004246 | |||||||||
| WBStrain00051863 | |||||||||
| WBStrain00054678 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000240 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006600 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cat-2 encodes a tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of catecholamines, such as dopamine; mutations in cat-2 affect dopamine levels that in turn affect locomotory slowing in response to food; CAT-2 demonstrates tyrosine hydroxylase activity in vitro, and this activity can be regulated, in vitro, by phosphorylation of CAT-2 Ser35 by protein kinase A; CAT-2 activity does not appear, however, to be regulated by other mechanisms, including substrate inhibition or feedback inhibition; cat-2 is expressed in dopaminergic as well as other neurons, male spicules, and male ray neurons. | Paper_evidence | WBPaper00003844 | |||||
| WBPaper00005147 | |||||||||
| WBPaper00037805 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 24 Nov 2010 00:00:00 | ||||||||
| Automated_description | Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Expressed in dopaminergic neurons; socket cell; and in male. Used to study several diseases, including amphetamine abuse; cocaine abuse; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; artery disease (multiple); and obesity. Is an ortholog of human TH (tyrosine hydroxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:670 | Homo sapiens | Paper_evidence | WBPaper00041148 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 May 2019 00:00:00 | ||||||||
| DOID:809 | Homo sapiens | Paper_evidence | WBPaper00041148 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 May 2019 00:00:00 | ||||||||
| DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00057070 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Jul 2021 00:00:00 | ||||||||
| DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00041959 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11782) | |||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11782) | ||||||
| DOID:0080855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11782) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11782) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11782) | ||||||
| Models_disease_asserted | WBDOannot00000689 | ||||||||
| WBDOannot00000690 | |||||||||
| WBDOannot00000691 | |||||||||
| WBDOannot00000969 | |||||||||
| WBDOannot00000970 | |||||||||
| Molecular_info | Corresponding_CDS | B0432.5a | |||||||
| B0432.5b | |||||||||
| B0432.5c | |||||||||
| Corresponding_CDS_history | B0432.5a:wp135 | ||||||||
| B0432.5a:wp222 | |||||||||
| B0432.5b:wp135 | |||||||||
| B0432.5b:wp222 | |||||||||
| Corresponding_transcript | B0432.5a.1 | ||||||||
| B0432.5b.1 | |||||||||
| B0432.5c.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (6) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00039060 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00009777 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114347 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114356 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076057 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028147 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1032 | ||||||||
| Expr2619 | |||||||||
| Expr16075 | |||||||||
| Expr16108 | |||||||||
| Expr1013007 | |||||||||
| Expr1143222 | |||||||||
| Expr2009727 | |||||||||
| Expr2027966 | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product (11) | |||||||||
| Regulate_expr_cluster | WBPaper00060921:cat-2(e1112)_downregulated | ||||||||
| WBPaper00060921:cat-2(e1112)_upregulated | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (46) | |||||||||
| Map_info | Map | II | Position | -15.661 | Error | 0.012551 | |||
| Positive | Positive_clone | B0432 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 34 | |||||||
| 797 | |||||||||
| Multi_point | 45 | ||||||||
| 273 | |||||||||
| 4244 | |||||||||
| 5512 | |||||||||
| Reference (194) | |||||||||
| Method | Gene |
