WormBase Tree Display for Gene: WBGene00006792

WBGene00006792 SMap: S_parent: Sequence: T06H11
  Identity: Version: 3
    Name: CGC_name: unc-58 Person_evidence: WBPerson261
      Sequence_name: T06H11.1
      Molecular_name (21)
      Other_name: twk-18 CGC_data_submission
        CELE_T06H11.1 Accession_evidence: NDB BX284606
      Public_name: unc-58
    DB_info: Database: AceView gene XK722
        WormQTL gene WBGene00006792
        WormFlux gene WBGene00006792
        NDB locus_tag CELE_T06H11.1
        Panther gene CAEEL|WormBase=WBGene00006792|UniProtKB=Q22271
          family PTHR11003
        NCBI gene 181224
        RefSeq protein NM_171758.5
            NM_001373460.3
            NM_001373459.2
            NM_001373458.4
            NM_001373457.2
            NM_001373456.2
            NM_171759.6
        SwissProt UniProtAcc Q22271
        TrEMBL UniProtAcc A0A4V0IKI8
            A0A4V0IL39
            A0A4V0IKM3
            A0A4V0INP7
            A0A4V0INX3
        UniProt_GCRP UniProtAcc Q22271
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143382
    Allele (568)
    Legacy_information: e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype).
      See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273
      [Reiner D]] Mac-h (Hyper-ACtivate Muscle)
      [C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT]
    Strain: WBStrain00026762
      WBStrain00026763
      WBStrain00026792
      WBStrain00027002
      WBStrain00004431
      WBStrain00004508
      WBStrain00004193
      WBStrain00006242
      WBStrain00055081
      WBStrain00054759
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (35)
    Paralog (47)
    Structured_description: Concise_description: unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. Paper_evidence: WBPaper00002305
            WBPaper00002665
            WBPaper00004644
            WBPaper00005654
            WBPaper00017138
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T06H11.1a
      T06H11.1b
      T06H11.1c
      T06H11.1d
      T06H11.1e
      T06H11.1f
      T06H11.1g
    Corresponding_CDS_history: T06H11.1:wp83
    Corresponding_transcript: T06H11.1a.1
      T06H11.1b.1
      T06H11.1c.1
      T06H11.1d.1
      T06H11.1e.1
      T06H11.1f.1
      T06H11.1g.1
    Other_sequence (29)
    Associated_feature (17)
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr2448
      Expr1020117
      Expr1021035
      Expr1028695
      Expr1032862
      Expr1156295
      Expr1156296
      Expr1156298
      Expr2017890
      Expr2036026
    Drives_construct: WBCnstr00010838
      WBCnstr00030566
      WBCnstr00030567
      WBCnstr00034146
    Construct_product: WBCnstr00010838
      WBCnstr00030566
      WBCnstr00030567
      WBCnstr00034146
    Microarray_results (51)
    Expression_cluster (171)
    Interaction: WBInteraction000028423
      WBInteraction000136892
      WBInteraction000165840
      WBInteraction000200024
      WBInteraction000243038
      WBInteraction000331659
      WBInteraction000418934
      WBInteraction000430959
      WBInteraction000456312
      WBInteraction000585544
  Map_info: Map: X Position: 1.75032 Error: 0.007954
    Well_ordered
    Positive: Inside_rearr: stDp2
        nDf19
      Positive_clone: T06H11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point (15)
      Multi_point: 442
        551
        651
        791
        792
        1343
        2260
        2454
        4314
        4494
      Pos_neg_data: 272
        497
        942
        656
        661
  Reference: WBPaper00000031
    WBPaper00000565
    WBPaper00000608
    WBPaper00000914
    WBPaper00001709
    WBPaper00002305
    WBPaper00002485
    WBPaper00004376
    WBPaper00005927
    WBPaper00006103
    WBPaper00013889
    WBPaper00014961
    WBPaper00015071
    WBPaper00016043
    WBPaper00016713
    WBPaper00017024
    WBPaper00017174
    WBPaper00017414
    WBPaper00017685
    WBPaper00021740
    WBPaper00022012
    WBPaper00022642
    WBPaper00023739
    WBPaper00023964
    WBPaper00026748
    WBPaper00027237
    WBPaper00027249
    WBPaper00028462
    WBPaper00029020
    WBPaper00038491
    WBPaper00038946
    WBPaper00040284
    WBPaper00041300
    WBPaper00048092
    WBPaper00052540
    WBPaper00052822
    WBPaper00055090
    WBPaper00056919
    WBPaper00059990
    WBPaper00062373
    WBPaper00064001
    WBPaper00064887
    WBPaper00065105
  Remark: The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6) CGC_data_submission
  Method: Gene