WormBase Tree Display for Gene: WBGene00006773

WBGene00006773 SMap: S_parent: Sequence: W02D3
  Identity: Version: 1
    Name: CGC_name: unc-37 Person_evidence: WBPerson261
      Sequence_name: W02D3.9
      Molecular_name: W02D3.9
        W02D3.9.1
        CE14434
      Other_name: let-76
        ESG Accession_evidence: EMBL AF001271
              AF001272
        CELE_W02D3.9 Accession_evidence: NDB BX284601
      Public_name: unc-37
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143071
    Allele (43)
    Legacy_information: e262 : weak coiler fairly active. ES2 ME1. NA1.
      s80 : L1 lethal. NA1.
      L1 lethal
      See also s80
      [C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC]
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (35)
    Contained_in_operon: CEOP1348
    Ortholog (54)
    Structured_description: Concise_description: unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. Paper_evidence: WBPaper00002798
            WBPaper00005042
            WBPaper00005136
            WBPaper00030973
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 May 2010 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: EFO:MONDO:0014769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30788)
  Molecular_info: Corresponding_CDS: W02D3.9
    Corresponding_transcript: W02D3.9.1
    Other_sequence (80)
    Associated_feature: WBsf034259
      WBsf649254
      WBsf664356
      WBsf664357
      WBsf664358
      WBsf983991
      WBsf1009987
      WBsf219629
      WBsf219630
    Transcription_factor: WBTranscriptionFactor000434
  Experimental_info: RNAi_result (34)
    Expr_pattern (11)
    Drives_construct (6)
    Construct_product: WBCnstr00006110
      WBCnstr00010892
    Antibody: WBAntibody00000145
    Microarray_results (22)
    Expression_cluster (138)
    Interaction (324)
  Map_info: Map: I Position: 1.30432 Error: 0.000643
    Well_ordered
    Positive: Inside_rearr: qDf16
        nDp1
      Positive_clone: W02D3 Person_evidence: WBPerson422
            WBPerson43
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 15
        7055
      Multi_point (24)
      Pos_neg_data (41)
  Reference: WBPaper00000031
    WBPaper00000427
    WBPaper00000608
    WBPaper00001155
    WBPaper00001557
    WBPaper00001639
    WBPaper00001692
    WBPaper00001826
    WBPaper00002774
    WBPaper00002798
    WBPaper00002829
    WBPaper00003053
    WBPaper00003757
    WBPaper00003985
    WBPaper00004402
    WBPaper00004509
    WBPaper00004594
    WBPaper00004710
    WBPaper00005042
    WBPaper00005237
    WBPaper00005295
    WBPaper00005423
    WBPaper00005445
    WBPaper00006049
    WBPaper00006052
    WBPaper00006260
    WBPaper00006364
    WBPaper00006419
    WBPaper00006457
    WBPaper00010417
    WBPaper00010445
    WBPaper00010528
    WBPaper00010957
    WBPaper00011049
    WBPaper00011052
    WBPaper00011060
    WBPaper00011085
    WBPaper00011123
    WBPaper00011194
    WBPaper00011211
    WBPaper00012694
    WBPaper00012706
    WBPaper00012725
    WBPaper00012746
    WBPaper00013867
    WBPaper00014383
    WBPaper00014722
    WBPaper00014723
    WBPaper00016378
    WBPaper00016529
    WBPaper00016753
    WBPaper00016754
    WBPaper00016755
    WBPaper00017027
    WBPaper00017118
    WBPaper00017450
    WBPaper00017466
    WBPaper00018040
    WBPaper00018568
    WBPaper00018571
    WBPaper00018650
    WBPaper00018813
    WBPaper00019283
    WBPaper00019775
    WBPaper00020884
    WBPaper00022186
    WBPaper00022335
    WBPaper00022498
    WBPaper00022541
    WBPaper00022665
    WBPaper00022815
    WBPaper00022985
    WBPaper00023157
    WBPaper00023374
    WBPaper00023402
    WBPaper00023586
    WBPaper00023793
    WBPaper00024161
    WBPaper00024162
    WBPaper00024291
    WBPaper00024433
    WBPaper00025235
    WBPaper00025296
    WBPaper00025759
    WBPaper00025826
    WBPaper00026093
    WBPaper00026196
    WBPaper00027237
    WBPaper00027287
    WBPaper00027299
    WBPaper00027309
    WBPaper00027318
    WBPaper00027751
    WBPaper00027764
    WBPaper00027892
    WBPaper00028106
    WBPaper00029033
    WBPaper00029115
    WBPaper00030203
    WBPaper00030287
    WBPaper00030930
    WBPaper00030954
    WBPaper00030973
    WBPaper00031299
    WBPaper00031496
    WBPaper00036201
    WBPaper00036225
    WBPaper00037678
    WBPaper00038491
    WBPaper00040106
    WBPaper00040144
    WBPaper00041771
    WBPaper00042343
    WBPaper00043908
    WBPaper00046378
    WBPaper00049531
    WBPaper00049689
    WBPaper00051941
    WBPaper00055090
    WBPaper00057859
    WBPaper00058332
    WBPaper00061547
    WBPaper00061738
    WBPaper00063208
    WBPaper00063728
    WBPaper00063732
    WBPaper00064339
    WBPaper00065308
    WBPaper00066217
  Remark: [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein.
  Method: Gene