WormBase Tree Display for Gene: WBGene00004860
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WBGene00004860 | SMap | S_parent | Sequence | C32D5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sma-6 | Person_evidence | WBPerson261 | |||||
Sequence_name | C32D5.2 | ||||||||
Molecular_name | C32D5.2 | ||||||||
C32D5.2.1 | |||||||||
CE01842 | |||||||||
Other_name | CELE_C32D5.2 | Accession_evidence | NDB | BX284602 | |||||
Public_name | sma-6 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sma | ||||||||
Reference_allele | WBVar00144032 | ||||||||
Allele (41) | |||||||||
Legacy_information | e1482 : short adult and late larvae. ES2 ME3. NA1. | ||||||||
[C.elegansII] e1482 : short adult and late larvae. e1482/Df similar. ES2 ME3. NA1. [CB] | |||||||||
Strain | WBStrain00023046 | ||||||||
WBStrain00003052 | |||||||||
WBStrain00026327 | |||||||||
WBStrain00026347 | |||||||||
WBStrain00030738 | |||||||||
WBStrain00037158 | |||||||||
WBStrain00004344 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (52) | |||||||||
Ortholog (60) | |||||||||
Paralog | WBGene00000897 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000900 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | sma-6 encodes a serine/threonine protein kinase that is orthologous to type I TGF-beta receptors; sma-6 activity is required for regulating body length and for proper development of the male tail; sma-6, along with other genes in the TGF-beta Sma/Mab pathway, also regulates reproductive aging; a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-6 expression first begins at the 1.5-fold stage of embryogenesis and continues through adulthood; sma-6 is expressed in dorsal and ventral hypodermis, pharyngeal muscle, and the intestine; expression in the hypodermis is necessary and sufficient for body length regulation. | Paper_evidence | WBPaper00003400 | |||||
WBPaper00005021 | |||||||||
WBPaper00035556 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 14 Jan 2011 00:00:00 | ||||||||
Automated_description | Enables BMP binding activity. Involved in several processes, including defense response to other organism; nematode male tail tip morphogenesis; and positive regulation of nitrogen compound metabolic process. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in ASI; hypodermis; intestinal cell; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including bone development disease (multiple); carcinoma (multiple); and glaucoma (multiple). Is an ortholog of human BMPR1B (bone morphogenetic protein receptor type 1B). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model (26) | ||||||||
Molecular_info | Corresponding_CDS | C32D5.2 | |||||||
Corresponding_transcript | C32D5.2.1 | ||||||||
Other_sequence (28) | |||||||||
Associated_feature | WBsf221420 | ||||||||
WBsf221421 | |||||||||
WBsf221422 | |||||||||
Experimental_info | RNAi_result | WBRNAi00114409 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041667 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097941 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00068065 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075914 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00024693 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067749 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027202 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090572 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027866 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00011477 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram1858 | ||||||||
Expr998 | |||||||||
Expr1297 | |||||||||
Expr1781 | |||||||||
Expr10559 | |||||||||
Expr1024381 | |||||||||
Expr1032412 | |||||||||
Expr1145692 | |||||||||
Expr2015896 | |||||||||
Expr2034129 | |||||||||
Drives_construct | WBCnstr00000281 | ||||||||
WBCnstr00003549 | |||||||||
WBCnstr00007037 | |||||||||
WBCnstr00010438 | |||||||||
WBCnstr00015614 | |||||||||
WBCnstr00035350 | |||||||||
Construct_product | WBCnstr00006336 | ||||||||
WBCnstr00007223 | |||||||||
WBCnstr00015614 | |||||||||
WBCnstr00018952 | |||||||||
WBCnstr00019032 | |||||||||
WBCnstr00035350 | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (113) | |||||||||
Interaction (248) | |||||||||
WBProcess | WBbiopr:00000025 | ||||||||
WBbiopr:00000039 | |||||||||
Map_info | Map | II | Position | -0.382096 | Error | 0.000481 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C32D5 | Person_evidence | WBPerson465 | |||||
Author_evidence | Krishna S | ||||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Negative | Outside_rearr | mDf14 | |||||||
Mapping_data | 2_point (2) | ||||||||
Multi_point | 843 | ||||||||
1360 | |||||||||
1719 | |||||||||
3796 | |||||||||
5272 | |||||||||
Pos_neg_data | 3710 | ||||||||
3711 | |||||||||
3712 | |||||||||
3713 | |||||||||
3714 | |||||||||
10459 | |||||||||
Reference (147) | |||||||||
Picture | WBPicture0000013077 | ||||||||
Method | Gene |