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WormBase Tree Display for Gene: WBGene00004774

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Name Class

WBGene00004774SMapS_parentSequenceC14F5
IdentityVersion1
NameCGC_namesem-5Person_evidenceWBPerson268
Sequence_nameC14F5.5
Molecular_nameC14F5.5
C14F5.5.1
CE01784
Other_nameCELE_C14F5.5Accession_evidenceNDBBX284606
Public_namesem-5
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsem
Allele (51)
Legacy_information[C.elegansII] n2030 : vulvaless, hermaphrodite sex muscles show subtle positioning defect, Soc (suppressor of clr-1),impenetrant Mel (rod-like larval lethal); pleiotropic effects on migration, vulval induction etc. ME0. OA5: strong alleles n1619, n2019; weaker alleles n1781, n2195 (Soc, weak Egl, ME3),n1619, n1779 (synergizes with alleles of unc-71,unc-73, egl-15, egl-17,to give stronger Sem defect). Cloned: encodes predicted SH3-SH2-SH3 protein with 60% identity to human GRB2, functional equivalence. [Clark et al. 1992; Stern et al. 1993; DeVore et al.1995; MT; NH]
StrainWBStrain00027118
WBStrain00027128
WBStrain00027153
WBStrain00027194
WBStrain00027242
WBStrain00028761
WBStrain00030723
WBStrain00035409
RNASeq_FPKM (74)
GO_annotation (22)
Contained_in_operonCEOPX092
Ortholog (44)
ParalogWBGene00006410Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionsem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355) and Drosophila Drk; sem-5 functions in multiple signaling pathways during development including those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, and IP-3-, mediated signal transduction; a sem-5::yfp promoter fusion is expressed in many cells throughout development, including the hypodermis, intestine, neurons, body wall muscles, and vulval precursor cells.Paper_evidenceWBPaper00001519
WBPaper00005353
WBPaper00005792
WBPaper00027119
Curator_confirmedWBPerson1843
Date_last_updated25 Aug 2009 00:00:00
Automated_descriptionEnables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; male genitalia development; and regulation of vulval development. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of COP9 signalosome. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114; breast cancer; and reproductive organ cancer (multiple). Is an ortholog of human GRB2 (growth factor receptor bound protein 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2871Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4566)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4566)
DOID:0111642Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4562)
DOID:2526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4566)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4566)
Molecular_infoCorresponding_CDSC14F5.5
Corresponding_transcriptC14F5.5.1
Other_sequence (33)
Associated_feature (17)
Experimental_infoRNAi_resultWBRNAi00109280Inferred_automaticallyRNAi_primary
WBRNAi00040567Inferred_automaticallyRNAi_primary
WBRNAi00024557Inferred_automaticallyRNAi_primary
WBRNAi00071623Inferred_automaticallyRNAi_primary
WBRNAi00086082Inferred_automaticallyRNAi_primary
WBRNAi00064750Inferred_automaticallyRNAi_primary
WBRNAi00067073Inferred_automaticallyRNAi_primary
WBRNAi00109571Inferred_automaticallyRNAi_primary
WBRNAi00107773Inferred_automaticallyRNAi_primary
WBRNAi00067284Inferred_automaticallyRNAi_primary
WBRNAi00086096Inferred_automaticallyRNAi_primary
WBRNAi00109377Inferred_automaticallyRNAi_primary
WBRNAi00116128Inferred_automaticallyRNAi_primary
WBRNAi00091412Inferred_automaticallyRNAi_primary
WBRNAi00066267Inferred_automaticallyRNAi_primary
WBRNAi00008396Inferred_automaticallyRNAi_primary
WBRNAi00071624Inferred_automaticallyRNAi_primary
WBRNAi00086125Inferred_automaticallyRNAi_primary
WBRNAi00064562Inferred_automaticallyRNAi_primary
WBRNAi00067071Inferred_automaticallyRNAi_primary
WBRNAi00067751Inferred_automaticallyRNAi_primary
WBRNAi00064777Inferred_automaticallyRNAi_primary
WBRNAi00109182Inferred_automaticallyRNAi_primary
WBRNAi00086094Inferred_automaticallyRNAi_primary
WBRNAi00086095Inferred_automaticallyRNAi_primary
WBRNAi00086081Inferred_automaticallyRNAi_primary
WBRNAi00064758Inferred_automaticallyRNAi_primary
WBRNAi00064516Inferred_automaticallyRNAi_primary
WBRNAi00027688Inferred_automaticallyRNAi_primary
WBRNAi00071727Inferred_automaticallyRNAi_primary
WBRNAi00109474Inferred_automaticallyRNAi_primary
WBRNAi00066176Inferred_automaticallyRNAi_primary
WBRNAi00107772Inferred_automaticallyRNAi_primary
WBRNAi00067941Inferred_automaticallyRNAi_primary
WBRNAi00067525Inferred_automaticallyRNAi_primary
Expr_patternExpr3985
Expr4588
Expr13649
Expr1026960
Expr1032366
Expr1144621
Expr2015743
Expr2033976
Drives_constructWBCnstr00011797
WBCnstr00012097
WBCnstr00035397
Construct_productWBCnstr00035397
Microarray_results (18)
Expression_cluster (115)
Interaction (368)
WBProcessWBbiopr:00000071
Map_infoMapXPosition-0.822248Error0.024961
Well_ordered
PositiveInside_rearrraDf2
raDf6
raDf7
raDf9
Positive_cloneC14F5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point4454
Multi_point1538
1539
1583
4730
5256
Pos_neg_data4455
9428
9430
9432
9435
Reference (166)
MethodGene