WormBase Tree Display for Gene: WBGene00006759

WBGene00006759 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 3
    Name: CGC_name: unc-22 Person_evidence: WBPerson261
      Sequence_name: ZK617.1
      Molecular_name (27)
      Other_name: twitchin kinase Paper_evidence: WBPaper00002642
        twitchin Paper_evidence: WBPaper00031595
        CELE_ZK617.1 Accession_evidence: NDB BX284604
      Public_name: unc-22
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 23 Feb 2010 15:11:48 WBPerson4025 Event: Acquires_merge: WBGene00014010
        3 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303099
      Acquires_merge: WBGene00014010
      Split_into: WBGene00303099
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142944
    Allele (644)
    Legacy_information: e66 : twitcher at all stages; (moves slowly with constant trembling); thin; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. NA > 200 (s32amber (resembles e66); m52dm; many Tc1 insertions etc.). Most unc-22/+ heterozygotes twitch in nicotine; abnormal muscle structure in most homozygotes; near normal muscle for alleles e105 s12 Tc1 induced alleles. See also unc-54.
      See also e66, e105, e308, e313, e320, e346, e640, e654, e682, e683, e691, e842, e855, e882, e913, e914, e915, e991, e1090, e1179, e1326, e1923, e2092, e2147, e2148, e2174, e2182, e2377, e2378, e2428, n789, n790, n791, n792, n793, s7, s8, s11, s12, s13, s14, s15, s16, s17, s18, s19, s20, s21, s22, s23, s24, s25, s28, s32, s34, s35, s36, s55, s56, s67, s135, s162, s164, s165, s183, s184, s264, s265, s266, s278, s279, s280, s281, s282, s283, s284, s285, s289, s292, s293, s294, s295, s296, s297, s298, s299, s300, s301, s302, s303, s304, s305, s306, s307, s308, s309, s310, s311, s312, s313, s314, s315, s316, s699, s700, s705, s724, s727, s1787, s1788, s1790, s1791, s1792, s1793, s2028, s2029, s2030, s2038, st136, st137, st192
      [C.elegansII] e66 : twitcher at all stages; (moves slowly with constant trembling); thin; abnormal muscle structure; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. OA>200:s32amb (resembles e66), m52dm,e105 (muscle structure near normal),e2428, s7, s12 (near normal muscle structure),s2038,st192 etc. Many Tc1 insertions, plus precise and imprecise excision revertants. Most unc-22/+ heterozygotes twitch in nicotine. Cloned: large gene (>30 kb), transcript ~19 kb,encodes 6049 aa twitchin: single kinase domain, multiple copies of fibronectin-like and Ig-like repeats. Antibody staining indicates twitchin associated with thick filaments. [Waterston et al. 1980; Benian et al. 1989, 1993; GB]
    Strain (134)
    RNASeq_FPKM: WBls:0000002 (84)
      WBls:0000003 (11)
      WBls:0000004 (40)
      WBls:0000006 1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559705
            RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559706
      WBls:0000007 (11)
      WBls:0000008 0.187372 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085219
        0.302936 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX145480
        0.684165 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085220
      WBls:0000010 (15)
      WBls:0000013 0.0339259 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX099997
        0.0566873 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX099998
        0.0985085 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX103652
        0.103385 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX099996
        0.1862 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX099986
        0.443167 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX1022570
        0.60828 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX1022571
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX099987
            RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX103653
        2.27003 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX1022648
        2.30576 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000013.Hermaphrodite.WBbt:0007833.SRP000401.SRX1022604
      WBls:0000014 (19)
      WBls:0000015 (24)
      WBls:0000017 0.418963 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343253
        0.653376 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343277
        0.700901 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0008115.SRP029448.SRX343342
        1.06204 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343324
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343325
            RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343304
            RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343305
            RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343252
            RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343254
        2.40856 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343278
      WBls:0000020 (16)
      WBls:0000021 (20)
      WBls:0000023 1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000023.Hermaphrodite.WBbt:0007833.SRP015688.SRX185639
      WBls:0000024 (71)
      WBls:0000027 (15)
      WBls:0000031 11.8643 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX047470
        41.7193 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103276
        44.4017 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103275
        45.7778 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103274
        47.4742 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103273
        50.3906 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX008139
        5.18985 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103277
      WBls:0000032 11.1571 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103985
        13.1534 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103983
        2.85662 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019178
        39.5477 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103984
        5.60322 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX008138
        6.36103 From_analysis: RNASeq.elegans.WBls:0000032.control_mean
            RNASeq.elegans.WBls:0000032.control_median
        9.86545 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019179
      WBls:0000035 (24)
      WBls:0000038 (77)
      WBls:0000041 (30)
      WBls:0000052 0.152099 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX008140
        5.58862 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103280
        5.93499 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103278
        6.00724 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103281
        6.45847 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103279
        8.44011 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX037199
        9.20784 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103269
        9.21152 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103271
        9.27531 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103270
        9.37033 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103272
      WBls:0000063 (101)
      WBls:0000064 (14)
      WBls:0000065 (16)
      WBls:0000068 3.61619 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265361
        3.74949 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265360
        4.14463 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265364
        4.75896 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265363
        5.27486 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265365
        5.53447 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265362
      WBls:0000131 0.00530649 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343223
        0.00559016 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343228
        1.08223e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343220
        1.8121e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343221
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343225
        2.60019e-11 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343226
        3.22085e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343229
        5.61529e-11 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343227
        8.29615e-12 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343222
      WBls:0000141 0.0875338 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000141.Hermaphrodite.WBbt:0007833.SRP029448.SRX343161
      WBls:0000151 (13)
      WBls:0000171 (15)
      WBls:0000181 0.0877775 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000181.Hermaphrodite.WBbt:0007833.SRP029448.SRX343164
      WBls:0000191 0.0837336 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000191.Hermaphrodite.WBbt:0007833.SRP029448.SRX343165
      WBls:0000201 0.021447 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0008115.SRP029448.SRX343331
        0.0475449 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0008115.SRP029448.SRX343332
        1.03527 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004804.SRP029448.SRX343238
        1.64923e-07 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0003810.SRP029448.SRX343312
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004015.SRP029448.SRX343287
            RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004015.SRP029448.SRX343288
            RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004458.SRP029448.SRX343261
            RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004458.SRP029448.SRX343262
            RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004804.SRP029448.SRX343236
            RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004804.SRP029448.SRX343237
        3.3226e-07 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0003810.SRP029448.SRX343313
        6.28901e-07 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000201.Hermaphrodite.WBbt:0004458.SRP029448.SRX343263
      WBls:0000221 0.0246724 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343315
        1.36333e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343266
        1.83315e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343334
        1.8469e-06 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004804.SRP029448.SRX343241
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343291
            RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343264
            RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343333
        3.33595e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343290
        3.84185e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343314
        7.79368e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343265
      WBls:0000231 0.171997 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000231.Hermaphrodite.WBbt:0007833.SRP029448.SRX343167
      WBls:0000251 0.0880093 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0003810.SRP029448.SRX343317
        0.0895674 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0007833.SRP029448.SRX343168
        1.2239e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343336
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004458.SRP029448.SRX343268
            RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343243
            RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343244
        2.18756e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343337
        3.03558e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343242
        4.06872e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343335
        8.84207e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004015.SRP029448.SRX343292
      WBls:0000261 0.103078 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000261.Hermaphrodite.WBbt:0007833.SRP029448.SRX343169
      WBls:0000281 0.103893 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000281.Hermaphrodite.WBbt:0007833.SRP029448.SRX343170
      WBls:0000291 (11)
      WBls:0000301 0.169404 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000301.Hermaphrodite.WBbt:0007833.SRP029448.SRX343172
      WBls:0000311 0.221188 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000311.Hermaphrodite.WBbt:0007833.SRP029448.SRX343173
      WBls:0000321 0.0338851 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000321.Hermaphrodite.WBbt:0007833.SRP029448.SRX343174
      WBls:0000331 0.0959832 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343176
        2.63296e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343175
      WBls:0000351 0.146051 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343179
        0.175994 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343178
      WBls:0000361 0.075591 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000361.Hermaphrodite.WBbt:0007833.SRP029448.SRX343180
      WBls:0000381 1.88388e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343275
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343297
            RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343299
            RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0008115.SRP029448.SRX343340
        2.19508e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343249
        2.60778e-08 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0003810.SRP029448.SRX343320
        2.61693e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343274
        9.70087e-09 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343250
        9.88913e-11 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343248
      WBls:0000391 0.432165 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000391.Hermaphrodite.WBbt:0007833.SRP029448.SRX343181
      WBls:0000401 0.736454 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000401.Hermaphrodite.WBbt:0007833.SRP029448.SRX343182
      WBls:0000421 0.0765452 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000421.Hermaphrodite.WBbt:0007833.SRP029448.SRX343184
      WBls:0000431 0.287932 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000431.Hermaphrodite.WBbt:0007833.SRP029448.SRX343185
      WBls:0000451 0.524048 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000451.Hermaphrodite.WBbt:0007833.SRP029448.SRX343186
      WBls:0000461 0.748359 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000461.Hermaphrodite.WBbt:0007833.SRP029448.SRX343187
      WBls:0000471 0.150431 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343302
        0.482877 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004458.SRP029448.SRX343276
        1e-10 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343300
            RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343301
            RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004804.SRP029448.SRX343251
            RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0008115.SRP029448.SRX343341
        5.34328e-07 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0007833.SRP029448.SRX343189
      WBls:0000491 0.299604 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000491.Hermaphrodite.WBbt:0007833.SRP029448.SRX343191
      WBls:0000501 0.505771 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000501.Hermaphrodite.WBbt:0007833.SRP029448.SRX343192
      WBls:0000511 1.24085 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000511.Hermaphrodite.WBbt:0007833.SRP029448.SRX343194
      WBls:0000521 1.60193 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000521.Hermaphrodite.WBbt:0007833.SRP029448.SRX343195
      WBls:0000531 0.0811382 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343197
        1.17539 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343196
      WBls:0000541 0.873192 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343198
        2.01162 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343199
      WBls:0000551 1.74582 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000551.Hermaphrodite.WBbt:0007833.SRP029448.SRX343200
      WBls:0000561 3.41389 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000561.Hermaphrodite.WBbt:0007833.SRP029448.SRX343201
      WBls:0000581 0.844434 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000581.Hermaphrodite.WBbt:0007833.SRP029448.SRX343202
      WBls:0000621 4.47072 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000621.Hermaphrodite.WBbt:0007833.SRP029448.SRX343203
      WBls:0000674 1.92168 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265366
        2.78527 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265369
        3.06892 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265370
        3.46794 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265371
        4.05378 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265368
        4.2035 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265367
      WBls:0000676 4.6706 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265374
        5.56014 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265372
        6.07735 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265375
        6.95959 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265373
      WBls:0000694 4.15069 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000694.Hermaphrodite.WBbt:0007833.SRP029448.SRX343205
      WBls:0000695 3.91805 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000695.Hermaphrodite.WBbt:0007833.SRP029448.SRX343206
      WBls:0000696 8.54162 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000696.Hermaphrodite.WBbt:0007833.SRP029448.SRX343207
      WBls:0000697 10.8806 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000697.Hermaphrodite.WBbt:0007833.SRP029448.SRX343208
      WBls:0000699 13.2544 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000699.Hermaphrodite.WBbt:0007833.SRP029448.SRX343210
      WBls:0000700 6.57991 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000700.Hermaphrodite.WBbt:0007833.SRP029448.SRX343211
      WBls:0000701 12.6561 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000701.Hermaphrodite.WBbt:0007833.SRP029448.SRX343212
      WBls:0000702 12.6756 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000702.Hermaphrodite.WBbt:0007833.SRP029448.SRX343213
      WBls:0000703 20.9799 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000703.Hermaphrodite.WBbt:0007833.SRP029448.SRX343214
    GO_annotation (30)
    Ortholog (42)
    Paralog (12)
    Structured_description: Concise_description: unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation. Paper_evidence: WBPaper00001203
            WBPaper00001773
            WBPaper00005546
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including adult behavior; positive regulation of sarcomere organization; and positive regulation of striated muscle contraction. Located in A band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2J; coronary artery disease; intrinsic cardiomyopathy (multiple); and tibial muscular dystrophy. Is an ortholog of human TTN (titin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111188 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110430 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0111078 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110315 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0081341 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
  Molecular_info: Corresponding_CDS: ZK617.1a
      ZK617.1b
      ZK617.1c
      ZK617.1d
      ZK617.1e
      ZK617.1f
      ZK617.1g
      ZK617.1h
      ZK617.1i
    Corresponding_CDS_history: ZK617.1a:wp92
      ZK617.1b:wp92
      ZK617.1c:wp229
      ZK617.1d:wp243
      ZK617.1j:wp264
    Corresponding_transcript: ZK617.1a.1
      ZK617.1b.1
      ZK617.1c.1
      ZK617.1d.1
      ZK617.1e.1
      ZK617.1f.1
      ZK617.1g.1
      ZK617.1h.1
      ZK617.1i.1
    Other_sequence (86)
    Associated_feature (32)
  Experimental_info: RNAi_result: WBRNAi00084131 Inferred_automatically: RNAi_primary
      WBRNAi00009481 Inferred_automatically: RNAi_primary
      WBRNAi00091261 Inferred_automatically: RNAi_primary
      WBRNAi00117473 Inferred_automatically: RNAi_primary
      WBRNAi00061327 Inferred_automatically: RNAi_primary
      WBRNAi00086327 Inferred_automatically: RNAi_primary
      WBRNAi00001236 Inferred_automatically: RNAi_primary
      WBRNAi00080196 Inferred_automatically: RNAi_primary
      WBRNAi00000409 Inferred_automatically: RNAi_primary
      WBRNAi00080194 Inferred_automatically: RNAi_primary
      WBRNAi00091263 Inferred_automatically: RNAi_primary
      WBRNAi00086336 Inferred_automatically: RNAi_primary
      WBRNAi00093844 Inferred_automatically: RNAi_primary
      WBRNAi00112560 Inferred_automatically: RNAi_primary
      WBRNAi00076023 Inferred_automatically: RNAi_primary
      WBRNAi00086326 Inferred_automatically: RNAi_primary
      WBRNAi00090129 Inferred_automatically: RNAi_primary
      WBRNAi00086341 Inferred_automatically: RNAi_primary
      WBRNAi00080198 Inferred_automatically: RNAi_primary
      WBRNAi00084123 Inferred_automatically: RNAi_primary
      WBRNAi00085911 Inferred_automatically: RNAi_primary
      WBRNAi00086332 Inferred_automatically: RNAi_primary
      WBRNAi00110441 Inferred_automatically: RNAi_primary
      WBRNAi00080201 Inferred_automatically: RNAi_primary
      WBRNAi00116304 Inferred_automatically: RNAi_primary
      WBRNAi00110298 Inferred_automatically: RNAi_primary
      WBRNAi00064656 Inferred_automatically: RNAi_primary
      WBRNAi00059558 Inferred_automatically: RNAi_primary
      WBRNAi00098726 Inferred_automatically: RNAi_primary
      WBRNAi00089969 Inferred_automatically: RNAi_primary
      WBRNAi00061328 Inferred_automatically: RNAi_primary
      WBRNAi00090287 Inferred_automatically: RNAi_primary
      WBRNAi00086333 Inferred_automatically: RNAi_primary
      WBRNAi00027082 Inferred_automatically: RNAi_primary
      WBRNAi00094574 Inferred_automatically: RNAi_primary
      WBRNAi00086337 Inferred_automatically: RNAi_primary
      WBRNAi00086340 Inferred_automatically: RNAi_primary
      WBRNAi00085910 Inferred_automatically: RNAi_primary
      WBRNAi00089785 Inferred_automatically: RNAi_primary
      WBRNAi00094576 Inferred_automatically: RNAi_primary
      WBRNAi00077259 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13345
      Expr13346
      Expr13347
      Expr13348
      Expr1013173
      Expr1032832
      Expr1162974
      Expr2017855
      Expr2035991
    Drives_construct: WBCnstr00039209
      WBCnstr00039210
      WBCnstr00039211
      WBCnstr00039212
    Construct_product: WBCnstr00001720
      WBCnstr00001721
      WBCnstr00001722
      WBCnstr00001723
      WBCnstr00001724
      WBCnstr00015909
    Antibody: WBAntibody00001511
      WBAntibody00001778
    Microarray_results (53)
    Expression_cluster (240)
    Interaction (67)
  Map_info: Map: IV Position: 5.45802 Error: 0.005203
    Well_ordered
    Positive: Inside_rearr: nDf28
        sDf8
      Positive_clone: LDM17
        YK1088
        ZK617 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf22
        mDp4
    Mapping_data: 2_point (67)
      Multi_point (125)
      Pos_neg_data (38)
    Landmark_gene
  Reference (371)
  Remark: yk16f10.3 removed from sequence list. sdm 11/00
  Method: Gene