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WormBase Tree Display for Gene: WBGene00006652

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Name Class

WBGene00006652SMapS_parentSequenceY113G7A
IdentityVersion1
NameCGC_namettx-1Person_evidenceWBPerson1417
Sequence_nameY113G7A.6
Molecular_name (12)
Other_nameEH67Paper_evidenceWBPaper00000161
PR767Paper_evidenceWBPaper00000680
CELE_Y113G7A.6Accession_evidenceNDBBX284605
Public_namettx-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classttx
Allele (456)
Possibly_affected_byWBVar02158831
Legacy_information[C.elegansII] p767 : mutant animals strongly cryophilic; hypersensitiveto dauer pheromone; neuron AFD lacks "fingers" (microvilli). [Perkins et al. 1986; FK]
StrainWBStrain00030792
WBStrain00031125
WBStrain00031126
WBStrain00037604
WBStrain00049306
WBStrain00048958
WBStrain00052015
WBStrain00055050
RNASeq_FPKM (74)
GO_annotation (44)
OrthologWBGene00069801Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00033797Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00140849Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00124871Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00227559Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g278Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g14278Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g4384Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g7303Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g1161Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g2278Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g6744Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g12105Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g18825Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g3791Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-ttx-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp5_scaffold_01966.g24127Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_19588Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_022029Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g09901Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g22133Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_50430800Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g18020Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00243095Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00116268Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00256978Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00287096Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0004102Drosophila melanogasterFrom_analysisOrthoFinder
OrthoInspector
Panther
ZFIN:ZDB-GENE-980526-27Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-980526-400Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-980526-406Danio rerioFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
ZFIN:ZDB-GENE-010403-1Danio rerioFrom_analysisEnsEMBL-Compara
OrthoInspector
SonicParanoid
HGNC:8521Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
Panther
SonicParanoid
HGNC:8522Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
SonicParanoid
MGI:97450Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
Panther
SonicParanoid
MGI:97451Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoInspector
SonicParanoid
RGD:3237Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoInspector
Panther
Paralog (20)
Structured_descriptionConcise_descriptionttx-1 encodes a homeodomain protein that is a member of the OTD/OTX subclass of homeodomain transcription factors; ttx-1 is expressed at higher levels in the AFD thermosensory neurons as compared to the AWB olfactory neurons and is necessary and partly sufficient for specification of the AFD thermosensory neuron fate and thus for proper AFD-mediated thermosensory behavior and normal expression of genes such as gcy-8, nhr-38, ceh-14, tax-2, and dac-1; TTX-1 is also required for remodeling of glial cells during dauer larval development which is mediated by regulation of ver-1 expression; a TTX-1::GFP fusion protein is nuclear and expressed in the AFD neurons and the nine pharyngeal marginal cells.Paper_evidenceWBPaper00000161
WBPaper00004879
WBPaper00024671
WBPaper00040681
WBPaper00038156
Curator_confirmedWBPerson1843
Date_last_updated08 Apr 2014 00:00:00
Automated_descriptionEnables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of plasma membrane bounded cell projection assembly; thermosensory behavior; and transcription by RNA polymerase II. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111806Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8522)
DOID:9410Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8522)
Molecular_infoCorresponding_CDSY113G7A.6a
Y113G7A.6b
Y113G7A.6c
Y113G7A.6d
Corresponding_CDS_historyY113G7A.6a:wp80
Y113G7A.6b:wp80
Corresponding_transcriptY113G7A.6a.1
Y113G7A.6b.1
Y113G7A.6c.1
Y113G7A.6d.1
Other_sequence (37)
Associated_feature (15)
Gene_product_bindsWBsf980903
WBsf980905
WBsf980906
Transcription_factorWBTranscriptionFactor000216
Experimental_info (9)
Map_infoMapVPosition24.5199Error0.016963
PositivePositive_cloneY113G7AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4325
4745
5371
Pseudo_map_position
Reference (90)
RemarkSequence connection from [Satterlee JS, Sengupta P]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene