WormBase Tree Display for Gene: WBGene00002295

WBGene00002295 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: let-19 Person_evidence: WBPerson533
      Sequence_name: K08F8.6
      Molecular_name: K08F8.6
        K08F8.6.1
        CE37536
      Other_name: psa-7
        pqn-49 CGC_data_submission
        TRAP240 Paper_evidence: WBPaper00019215
            WBPaper00016814
            WBPaper00011973
        mdt-13 Author_evidence: Bourbon H-M
        CELE_K08F8.6 Accession_evidence: NDB BX284602
      Public_name: let-19
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: let
    Reference_allele: WBVar00089001
    Allele (121)
    Legacy_information: mn19 : larval lethal. NA1.
      [C.elegansII] mn19 : larval lethal. NA1. [Sigurdson et al.; SP]
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation: 00085956
      00085957
      00085958
      00085959
      00085960
      00110353
      00110354
      00110355
    Ortholog: WBGene00053306 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026086 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00161999 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00164009 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00108105 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00225192 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g7511 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g305 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g15006 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17066 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g20242 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16897 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9415 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7427 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6846 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6847 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g22407 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00178.g6304 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-let-19 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g7711 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00010.g685 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_09325 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02090 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g1413 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20315720 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g5339 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00129850 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00212363 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00247918 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266549 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00290370 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297704 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002851 Saccharomyces cerevisiae From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0003415 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-3529 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070627-13 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:22474 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:22962 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2670178 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3029632 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1304829 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305884 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00007384 Caenorhabditis elegans From_analysis: Panther
      WBGene00016922 Caenorhabditis elegans From_analysis: Panther
      WBGene00019300 Caenorhabditis elegans From_analysis: Panther
      WBGene00012647 Caenorhabditis elegans From_analysis: Panther
      WBGene00011190 Caenorhabditis elegans From_analysis: Panther
      WBGene00019645 Caenorhabditis elegans From_analysis: Panther
      WBGene00010594 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling. Paper_evidence: WBPaper00000715
            WBPaper00012853
            WBPaper00017142
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in several structures, including TL.a; TL.p; TR.a; TR.p; and seam cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and dextro-looped transposition of the great arteries. Is an ortholog of human MED13 (mediator complex subunit 13) and MED13L (mediator complex subunit 13L). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:22474)
      DOID:0060770 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:22962)
  Molecular_info: Corresponding_CDS: K08F8.6
    Corresponding_CDS_history: K08F8.6:wp132
    Corresponding_transcript: K08F8.6.1
    Other_sequence (24)
    Associated_feature: WBsf657998
      WBsf657999
      WBsf658000
      WBsf658001
      WBsf658002
      WBsf988820
      WBsf1012745
      WBsf221813
  Experimental_info: RNAi_result (28)
    Expr_pattern: Chronogram948
      Expr2971
      Expr3488
      Expr6371
      Expr13300
      Expr1013091
      Expr1031345
      Expr1154034
      Expr2013049
      Expr2031281
    Drives_construct: WBCnstr00003412
      WBCnstr00011055
      WBCnstr00011420
      WBCnstr00016096
      WBCnstr00036336
    Construct_product: WBCnstr00011055
      WBCnstr00011420
      WBCnstr00036336
    Microarray_results (20)
    Expression_cluster (140)
    Interaction (52)
  Map_info: Map: II Position: 0.887503 Error: 0.002788
    Well_ordered
    Positive: Inside_rearr: mnDf46
        mnDf47
        mnDf48
      Positive_clone: K08F8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Negative: Outside_rearr: mDf17
    Mapping_data: Multi_point: 1467
        4168
        4659
      Pos_neg_data (20)
  Reference (24)
  Remark: psa-7 is allelic with let-19 [Sawa H]
  Method: Gene