WormBase Tree Display for Gene: WBGene00006792
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WBGene00006792 | SMap | S_parent | Sequence | T06H11 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | unc-58 | Person_evidence | WBPerson261 | |||||
Sequence_name | T06H11.1 | ||||||||
Molecular_name (21) | |||||||||
Other_name | twk-18 | CGC_data_submission | |||||||
CELE_T06H11.1 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | unc-58 | ||||||||
DB_info | Database | AceView | gene | XK722 | |||||
WormQTL | gene | WBGene00006792 | |||||||
WormFlux | gene | WBGene00006792 | |||||||
NDB | locus_tag | CELE_T06H11.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006792|UniProtKB=Q22271 | |||||||
family | PTHR11003 | ||||||||
NCBI | gene | 181224 | |||||||
RefSeq | protein | NM_171758.5 | |||||||
NM_001373460.3 | |||||||||
NM_001373459.2 | |||||||||
NM_001373458.4 | |||||||||
NM_001373457.2 | |||||||||
NM_001373456.2 | |||||||||
NM_171759.6 | |||||||||
SwissProt | UniProtAcc | Q22271 | |||||||
TrEMBL | UniProtAcc | A0A4V0IKI8 | |||||||
A0A4V0IL39 | |||||||||
A0A4V0IKM3 | |||||||||
A0A4V0INP7 | |||||||||
A0A4V0INX3 | |||||||||
UniProt_GCRP | UniProtAcc | Q22271 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011553 | ||||
3 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011552 | ||||
Acquires_merge | WBGene00011553 | ||||||||
WBGene00011552 | |||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143382 | ||||||||
Allele (568) | |||||||||
Legacy_information | e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). | ||||||||
See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273 | |||||||||
[Reiner D]] Mac-h (Hyper-ACtivate Muscle) | |||||||||
[C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT] | |||||||||
Strain | WBStrain00026762 | ||||||||
WBStrain00026763 | |||||||||
WBStrain00026792 | |||||||||
WBStrain00027002 | |||||||||
WBStrain00004431 | |||||||||
WBStrain00004508 | |||||||||
WBStrain00004193 | |||||||||
WBStrain00006242 | |||||||||
WBStrain00055081 | |||||||||
WBStrain00054759 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Ortholog (35) | |||||||||
Paralog (47) | |||||||||
Structured_description | Concise_description | unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. | Paper_evidence | WBPaper00002305 | |||||
WBPaper00002665 | |||||||||
WBPaper00004644 | |||||||||
WBPaper00005654 | |||||||||
WBPaper00017138 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS (7) | ||||||||
Corresponding_CDS_history | T06H11.1:wp83 | ||||||||
Corresponding_transcript | T06H11.1a.1 | ||||||||
T06H11.1b.1 | |||||||||
T06H11.1c.1 | |||||||||
T06H11.1d.1 | |||||||||
T06H11.1e.1 | |||||||||
T06H11.1f.1 | |||||||||
T06H11.1g.1 | |||||||||
Other_sequence (29) | |||||||||
Associated_feature (17) | |||||||||
Experimental_info | RNAi_result (16) | ||||||||
Expr_pattern | Expr2448 | ||||||||
Expr1020117 | |||||||||
Expr1021035 | |||||||||
Expr1028695 | |||||||||
Expr1032862 | |||||||||
Expr1156295 | |||||||||
Expr1156296 | |||||||||
Expr1156298 | |||||||||
Expr2017890 | |||||||||
Expr2036026 | |||||||||
Drives_construct | WBCnstr00010838 | ||||||||
WBCnstr00030566 | |||||||||
WBCnstr00030567 | |||||||||
WBCnstr00034146 | |||||||||
Construct_product | WBCnstr00010838 | ||||||||
WBCnstr00030566 | |||||||||
WBCnstr00030567 | |||||||||
WBCnstr00034146 | |||||||||
Microarray_results | SMD_T06H11.1 | ||||||||
SMD_T06H11.2 | |||||||||
SMD_T06H11.3 | |||||||||
181663_at | |||||||||
188242_at | |||||||||
194049_at | |||||||||
A_12_P105204 | |||||||||
A_12_P117024 | |||||||||
Aff_T06H11.1 | |||||||||
Aff_T06H11.2 | |||||||||
Aff_T06H11.3 | |||||||||
GPL13394_WBGene00006792 | |||||||||
GPL13394_WBGene00011553 | |||||||||
GPL13914_T06H11.1 | |||||||||
GPL13914_T06H11.5 | |||||||||
GPL14144_T06H11.1a_1227-1286_0.915_12_B | |||||||||
GPL14144_T06H11.1a_1354-1413_0.930_10_A | |||||||||
GPL14144_T06H11.1a_957-1016_0.900_13_C | |||||||||
GPL14144_T06H11.2_58-117_0.801_6_A | |||||||||
GPL14144_T06H11.5_137-196_0.885_27_C | |||||||||
GPL14144_T06H11.5_316-375_0.948_4_B | |||||||||
GPL14144_T06H11.5_356-415_0.962_1_A | |||||||||
GPL19516_CGZ0033827 | |||||||||
GPL19516_CGZ0033828 | |||||||||
GPL19516_CGZ0033829 | |||||||||
GPL19516_CGZ0033833 | |||||||||
GPL21109_T06H11.1a | |||||||||
GPL21109_T06H11.2 | |||||||||
GPL21109_T06H11.5 | |||||||||
GPL3518_CE02332 | |||||||||
GPL3518_CE31595 | |||||||||
GPL8304_CE_WBGene00006792_A | |||||||||
GPL8304_CE_WBGene00011552_A | |||||||||
GPL8304_CE_WBGene00011553_A | |||||||||
GPL8673_T06H11_1aP00284 | |||||||||
GPL8673_T06H11_1aP00948 | |||||||||
GPL8673_T06H11_1aP01386 | |||||||||
GPL8673_T06H11_1bP00207 | |||||||||
GPL8673_T06H11_1bP00212 | |||||||||
GPL8673_T06H11_1bP00218 | |||||||||
GPL8673_T06H11_2P00036 | |||||||||
GPL8673_T06H11_2P00048 | |||||||||
GPL8673_T06H11_2P00104 | |||||||||
GPL8673_T06H11_5P00152 | |||||||||
GPL8673_T06H11_5P00338 | |||||||||
GPL9450_T06H11.1a | |||||||||
GPL9450_T06H11.1b | |||||||||
GPL9450_T06H11.2 | |||||||||
cea2.d.05349 | |||||||||
cea2.d.05354 | |||||||||
cea2.i.56883 | |||||||||
Expression_cluster (171) | |||||||||
Interaction | WBInteraction000028423 | ||||||||
WBInteraction000136892 | |||||||||
WBInteraction000165840 | |||||||||
WBInteraction000200024 | |||||||||
WBInteraction000243038 | |||||||||
WBInteraction000331659 | |||||||||
WBInteraction000418934 | |||||||||
WBInteraction000430959 | |||||||||
WBInteraction000456312 | |||||||||
WBInteraction000585544 | |||||||||
Map_info | Map | X | Position | 1.75032 | Error | 0.007954 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | stDp2 | |||||||
nDf19 | |||||||||
Positive_clone | T06H11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point (15) | ||||||||
Multi_point | 442 | ||||||||
551 | |||||||||
651 | |||||||||
791 | |||||||||
792 | |||||||||
1343 | |||||||||
2260 | |||||||||
2454 | |||||||||
4314 | |||||||||
4494 | |||||||||
Pos_neg_data | 272 | ||||||||
497 | |||||||||
942 | |||||||||
656 | |||||||||
661 | |||||||||
Reference (43) | |||||||||
Remark | The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6) | CGC_data_submission | |||||||
Method | Gene |