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WormBase Tree Display for Gene: WBGene00003012

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WBGene00003012	SMap	S_parent	Sequence	F18A1
	Identity	Version	1
		Name	CGC_name	lin-26	Person_evidence	WBPerson261
			Sequence_name	F18A1.2
			Molecular_name (12)
			Other_name	CELE_F18A1.2	Accession_evidence	NDB	BX284602
			Public_name	lin-26
		DB_info	Database	AceView	gene	2H973
				WormQTL	gene	WBGene00003012
				SignaLink	protein	WBGene00003012
				WormFlux	gene	WBGene00003012
				NDB	locus_tag	CELE_F18A1.2
				NCBI	gene	3565051
				RefSeq	protein	NM_001306657.3
						NM_001306658.3
						NM_001356872.3
						NM_001026921.6
				SwissProt	UniProtAcc	Q27355
				UniProt_GCRP	UniProtAcc	Q27355
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:30	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	lin
		Reference_allele	WBVar00089290
		Allele (43)
		Legacy_information	n156 : adult hermaphrodites vulvaless ( > 99%) slightly small and fat HME1. ES2. Males very small scrawny rounded tail ME0. n156/Df is larval lethal. NA1.
			[Labouesse M] n156 animals were injected together with rol-6(su1006) at 80 ng/microl and F2 rollers were picked and ability to lay eggs was scored as rescue (n156 animals are vulvaless and hence bag). The cosmids were injected at a concentration of 10 ng/microlitre or less. Further subcloning showed a 9 kb fragment from K06E5 to be sufficient to rescue n156.
			See also n156
			[Labouesse M] mc2 and mc4 are embryonic lethals. mc2 mild loss-of-function, mc4 is strong.
			[Sookhareea S & Labouesse M] pk38/mc15 null mutation similar phenotype to mc1 & mc4. emb-lethal plus degeneration of hyp cells and glial cells.
			[C.elegansII] n156 : adult hermaphrodites vulvaless ( >99%), slightly small and fat; HME1. General hypodermal and support cell defects,hypodermal cells die or neuralize. 2% sterile.ES2. Males very small scrawny rounded tail; ME0. n156/Df is larval lethal. OA4: mc1, mc2 (both embryonic lethal),pk38tci, mc15 (deletion derivative). Cloned: encodes predicted zinc finger transcription factor. Antibody stains hypodermis,support cells, uterine cells. [Labouesse et al. 1994; MT; ML]
		Complementation_data	C18C9 (2 F2 rescued Rol/ 3 F2 lines); K06E5 (6 F2 rescuedRol lines / 6 F2 lines); C24G10 (0 F2 rescued Rol/ 2 lines and 0 F2 recued lines / 14 F2 Rol lines when injected in combination with C09G7); C36F4 (0 F2 rescued Rol lines/ 1 F2 Rol line); C18D9 ( 0 F2 rescued Rol line/ 1 F2 Rol) C43A1 (O rescued/ 3 F2 Rol lines); F31B8 (4 F2 recued Rol lines/ 6 F2 Rol lines)
		Strain (15)
		RNASeq_FPKM (74)
		GO_annotation (19)
		Contained_in_operon	CEOP2300
		Ortholog (20)
		Paralog	WBGene00003044	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00003045	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00003046	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00010264	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00013350	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00018740	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00018833	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00304808	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	lin-26 encodes a zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2, and LIR-3; during development, lin-26 activity is required for proper differentiation of non-neuronal ectodermal cells and the somatic gonad epithelium; LIN-26 is expressed in many different cell types including the rectal rep, somatic gonad, glial, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation.	Paper_evidence	WBPaper00002025
						WBPaper00002551
						WBPaper00003169
						WBPaper00003422
						WBPaper00004780
					Curator_confirmed	WBPerson1843
					Date_last_updated	05 Dec 2006 00:00:00
			Automated_description	Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; tissue development; and vulval development. Located in nucleus. Expressed in several structures, including Z2; epithelial cell; germ line; gonad; and somatic gonad precursor.	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	F18A1.2a
			F18A1.2b
			F18A1.2c
			F18A1.2d
		Corresponding_CDS_history	F18A1.2a:wp127
			F18A1.2b:wp127
		Corresponding_transcript	F18A1.2a.1
			F18A1.2b.1
			F18A1.2c.1
			F18A1.2d.1
		Other_sequence	Dviv_isotig25737
			CR09194
			CR12344
			Acan_isotig04726
			CR01875
			CR03487
			CJC08342_1
			Oden_isotig20186
			CRC00413_1
		Associated_feature (10)
		Transcription_factor	WBTranscriptionFactor000314
	Experimental_info	RNAi_result (25)
		Expr_pattern (17)
		Drives_construct (34)
		Construct_product	WBCnstr00000938
			WBCnstr00000939
			WBCnstr00000940
			WBCnstr00036285
		Antibody	WBAntibody00000122
			WBAntibody00001543
		Microarray_results (40)
		Expression_cluster (146)
		SAGE_tag (19)
		Interaction	WBInteraction000002534
			WBInteraction000003284
			WBInteraction000003437
			WBInteraction000003438
			WBInteraction000003439
			WBInteraction000009797
			WBInteraction000009798
			WBInteraction000028930
			WBInteraction000029360
			WBInteraction000030114
			WBInteraction000043503
			WBInteraction000043505
			WBInteraction000052283
			WBInteraction000126206
			WBInteraction000126835
			WBInteraction000127042
			WBInteraction000134274
			WBInteraction000134572
			WBInteraction000149199
			WBInteraction000165471
			WBInteraction000165676
			WBInteraction000165977
			WBInteraction000185265
			WBInteraction000185266
			WBInteraction000185267
			WBInteraction000196901
			WBInteraction000228742
			WBInteraction000228745
			WBInteraction000238808
			WBInteraction000259652
			WBInteraction000288664
			WBInteraction000288667
			WBInteraction000297912
			WBInteraction000297913
			WBInteraction000306758
			WBInteraction000324458
			WBInteraction000328343
			WBInteraction000359470
			WBInteraction000361320
			WBInteraction000366802
			WBInteraction000370348
			WBInteraction000372613
			WBInteraction000395600
			WBInteraction000398569
			WBInteraction000408346
			WBInteraction000410904
			WBInteraction000462936
			WBInteraction000462937
			WBInteraction000501671
			WBInteraction000501672
			WBInteraction000501695
			WBInteraction000501696
			WBInteraction000501876
			WBInteraction000501967
			WBInteraction000501968
			WBInteraction000501969
			WBInteraction000501970
			WBInteraction000503776
			WBInteraction000503777
			WBInteraction000503778
			WBInteraction000505339
			WBInteraction000505345
			WBInteraction000505366
			WBInteraction000505377
			WBInteraction000505465
			WBInteraction000517582
			WBInteraction000520187
			WBInteraction000520188
			WBInteraction000521953
			WBInteraction000528389
			WBInteraction000528451
			WBInteraction000528465
			WBInteraction000528469
			WBInteraction000528659
			WBInteraction000528711
			WBInteraction000528787
			WBInteraction000529082
			WBInteraction000529231
			WBInteraction000529308
			WBInteraction000529612
			WBInteraction000529643
			WBInteraction000529886
			WBInteraction000530249
			WBInteraction000530350
			WBInteraction000530397
			WBInteraction000530405
			WBInteraction000530740
			WBInteraction000531106
			WBInteraction000531197
			WBInteraction000531270
			WBInteraction000531278
			WBInteraction000531287
			WBInteraction000531387
			WBInteraction000531646
			WBInteraction000531961
			WBInteraction000532006
			WBInteraction000532060
			WBInteraction000532448
			WBInteraction000532531
			WBInteraction000532847
			WBInteraction000533187
			WBInteraction000533196
			WBInteraction000533466
			WBInteraction000533520
			WBInteraction000533867
			WBInteraction000533899
			WBInteraction000533933
			WBInteraction000534240
			WBInteraction000534362
			WBInteraction000534367
			WBInteraction000534388
			WBInteraction000534421
			WBInteraction000534591
			WBInteraction000534674
			WBInteraction000535006
			WBInteraction000535057
			WBInteraction000535206
			WBInteraction000535218
			WBInteraction000535391
			WBInteraction000539229
			WBInteraction000541695
			WBInteraction000541696
			WBInteraction000541697
			WBInteraction000541698
			WBInteraction000541699
			WBInteraction000541700
			WBInteraction000541701
			WBInteraction000541702
			WBInteraction000549201
			WBInteraction000550387
			WBInteraction000556911
			WBInteraction000556914
			WBInteraction000556917
			WBInteraction000556934
			WBInteraction000570606
			WBInteraction000574068
			WBInteraction000574638
			WBInteraction000575213
			WBInteraction000577310
			WBInteraction000582262
	Map_info	Map	II	Position	0.516432
		Well_ordered
		Positive	Inside_rearr	mcDf1	Person_evidence	WBPerson351
				mnDf88	Person_evidence	WBPerson351
				mnDf105	Person_evidence	WBPerson351
			Positive_clone	C18C9
				F18A1	Inferred_automatically	From sequence, transcript, pseudogene data
				F31B8
				K06E5
		Negative	Outside_rearr	mcDf3
			Negative_clone	C01D8
				C09G7
				C18D9
				C24G10
				C36F4
				F43A1
		Mapping_data	Multi_point	706
				707
				708
				709
				710
				711
				4479
				4530
				5721
			Pos_neg_data	6903
				6904
				6905
				6906
				6907
				6908
				6909
				8955
				10239
		Landmark_gene
	Reference (137)
	Method	Gene