lin-10 encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.
Enables small GTPase binding activity. Involved in several processes, including neuron-neuron synaptic transmission; positive regulation of backward locomotion; and protein localization. Located in several cellular components, including Golgi trans cisterna; somatodendritic compartment; and trans-Golgi network transport vesicle. Expressed in several structures, including ganglia; somatic gonad precursor; somatic nervous system; vulva; and vulval precursor cell. Is an ortholog of human APBA1 (amyloid beta precursor protein binding family A member 1) and APBA2 (amyloid beta precursor protein binding family A member 2).