WormBase Tree Display for Gene: WBGene00006600
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WBGene00006600 | SMap | S_parent | Sequence | ZK1290 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | tph | ||||||
Allele (36) | |||||||
Strain (17) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00015892 | ||||||
00015893 | |||||||
00015894 | |||||||
00015895 | |||||||
00015896 | |||||||
00015897 | |||||||
00015898 | |||||||
00015899 | |||||||
00015900 | |||||||
00015901 | |||||||
00015902 | |||||||
00015903 | |||||||
00015904 | |||||||
00015905 | |||||||
00015906 | |||||||
00015907 | |||||||
00015908 | |||||||
00015909 | |||||||
00015910 | |||||||
00015911 | |||||||
00015912 | |||||||
00015913 | |||||||
00015914 | |||||||
00015915 | |||||||
00015916 | |||||||
00015917 | |||||||
00080468 | |||||||
00080469 | |||||||
00080470 | |||||||
00080471 | |||||||
00105908 | |||||||
00105926 | |||||||
00105954 | |||||||
00114431 | |||||||
00114432 | |||||||
00114433 | |||||||
00114434 | |||||||
00114435 | |||||||
00114436 | |||||||
Ortholog (39) | |||||||
Paralog | WBGene00000240 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000296 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | tph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons. | Paper_evidence | WBPaper00003903 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 29 Nov 2005 00:00:00 | ||||||
Automated_description | Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including determination of adult lifespan; locomotory exploration behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol and neuron projection. Expressed in CP neuron; nerve ring; and pharynx. Used to study alcohol use disorder and cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; attention deficit hyperactivity disorder; and autistic disorder. Is an ortholog of human TPH1 (tryptophan hydroxylase 1) and TPH2 (tryptophan hydroxylase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||
DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00034740 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 17 Jun 2019 00:00:00 | ||||||
Potential_model (12) | |||||||
Models_disease_asserted | WBDOannot00000681 | ||||||
WBDOannot00000714 | |||||||
Molecular_info | Corresponding_CDS | ZK1290.2a | |||||
ZK1290.2b | |||||||
Corresponding_CDS_history | ZK1290.2a:wp151 | ||||||
ZK1290.2b:wp151 | |||||||
Corresponding_transcript | ZK1290.2a.1 | ||||||
ZK1290.2b.1 | |||||||
Other_sequence | GRC01852_1 | ||||||
BXC05583_1 | |||||||
ES739311.1 | |||||||
EY473361.1 | |||||||
HBC24515_1 | |||||||
GR12810 | |||||||
Associated_feature | WBsf019094 | ||||||
WBsf221610 | |||||||
Experimental_info | RNAi_result | WBRNAi00114357 | Inferred_automatically | RNAi_primary | |||
WBRNAi00027046 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00114348 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027047 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027556 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027880 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00102730 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059211 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021865 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (20) | |||||||
Drives_construct (60) | |||||||
Construct_product | WBCnstr00006436 | ||||||
WBCnstr00006466 | |||||||
WBCnstr00009598 | |||||||
WBCnstr00018069 | |||||||
WBCnstr00022691 | |||||||
WBCnstr00022692 | |||||||
WBCnstr00022700 | |||||||
WBCnstr00034278 | |||||||
WBCnstr00038791 | |||||||
Regulate_expr_cluster | WBPaper00059224:tph-1(mg280)_downregulated | ||||||
WBPaper00059224:tph-1(mg280)_upregulated | |||||||
WBPaper00060921:tph-1(mg280)_downregulated | |||||||
WBPaper00060921:tph-1(mg280)_upregulated | |||||||
Antibody | WBAntibody00000253 | ||||||
Microarray_results (28) | |||||||
Expression_cluster (68) | |||||||
Interaction (128) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
Map_info | Map | II | Position | 0.504594 | Error | 5.8e-05 | |
Positive | Positive_clone | ZK1290 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4715 | |||||
4733 | |||||||
Pseudo_map_position | |||||||
Reference (270) | |||||||
Remark | Sequence connection from [Sze JY, Ruvkun G] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |