WormBase Tree Display for Gene: WBGene00002004
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WBGene00002004 | Evidence | Paper_evidence | WBPaper00005342 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y53C10A | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | hsf-1 | Person_evidence | WBPerson1157 | |||||
Sequence_name | Y53C10A.12 | ||||||||
Molecular_name | Y53C10A.12 | ||||||||
Y53C10A.12.1 | |||||||||
CE22380 | |||||||||
Y53C10A.12.2 | |||||||||
Other_name | CELE_Y53C10A.12 | Accession_evidence | NDB | BX284601 | |||||
Public_name | hsf-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hsf | ||||||||
Allele (276) | |||||||||
Possibly_affected_by | WBVar02153033 | ||||||||
Strain (20) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00018735 | ||||||||
00018736 | |||||||||
00018737 | |||||||||
00018738 | |||||||||
00018739 | |||||||||
00018740 | |||||||||
00018741 | |||||||||
00018742 | |||||||||
00018743 | |||||||||
00018744 | |||||||||
00018745 | |||||||||
00018746 | |||||||||
00018747 | |||||||||
00018748 | |||||||||
00018749 | |||||||||
00018750 | |||||||||
00018751 | |||||||||
00018752 | |||||||||
00018753 | |||||||||
00018754 | |||||||||
00018755 | |||||||||
00018756 | |||||||||
00018757 | |||||||||
00018758 | |||||||||
00018759 | |||||||||
00018760 | |||||||||
00018761 | |||||||||
00018762 | |||||||||
00018763 | |||||||||
00018764 | |||||||||
00018765 | |||||||||
00018766 | |||||||||
00018767 | |||||||||
00018768 | |||||||||
00018769 | |||||||||
00018770 | |||||||||
00018771 | |||||||||
00018772 | |||||||||
00018773 | |||||||||
00018774 | |||||||||
00018775 | |||||||||
00018776 | |||||||||
00018777 | |||||||||
00018778 | |||||||||
00018779 | |||||||||
00018780 | |||||||||
00018781 | |||||||||
00018782 | |||||||||
00018783 | |||||||||
00018784 | |||||||||
00018785 | |||||||||
00018786 | |||||||||
00018787 | |||||||||
00018788 | |||||||||
00018789 | |||||||||
00018790 | |||||||||
00018791 | |||||||||
00018792 | |||||||||
00018793 | |||||||||
00018794 | |||||||||
00018795 | |||||||||
00018796 | |||||||||
00018797 | |||||||||
00018798 | |||||||||
00018799 | |||||||||
00018800 | |||||||||
00018801 | |||||||||
00018802 | |||||||||
00018803 | |||||||||
00018804 | |||||||||
00018805 | |||||||||
00018806 | |||||||||
00018807 | |||||||||
00018808 | |||||||||
00018809 | |||||||||
00018810 | |||||||||
00018811 | |||||||||
00018812 | |||||||||
00018813 | |||||||||
00018814 | |||||||||
00018815 | |||||||||
00018816 | |||||||||
00018817 | |||||||||
00018818 | |||||||||
00018819 | |||||||||
00018820 | |||||||||
00018821 | |||||||||
00018822 | |||||||||
00109866 | |||||||||
00109867 | |||||||||
00109868 | |||||||||
Ortholog (42) | |||||||||
Structured_description | Concise_description | hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan; HSF-1 binds bovine calmodulin in vitro in a calcium-dependent manner. | Paper_evidence | WBPaper00005342 | |||||
WBPaper00005851 | |||||||||
WBPaper00006377 | |||||||||
WBPaper00024662 | |||||||||
WBPaper00026999 | |||||||||
WBPaper00027347 | |||||||||
WBPaper00028353 | |||||||||
WBPaper00028419 | |||||||||
WBPaper00031011 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 04 May 2010 00:00:00 | ||||||||
Automated_description | Enables several functions, including calmodulin binding activity; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including ascaroside biosynthetic process; defense response to other organism; and positive regulation of metabolic process. Located in cytoplasm; nuclear body; and nuclear stress granule. Part of chromatin. Expressed in several structures, including germ cell; hypodermis; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in Huntington's disease and cataract 5 multiple types. Is an ortholog of human HSF1 (heat shock transcription factor 1) and HSF2 (heat shock transcription factor 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5224) | ||||
DOID:0110255 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5227) | ||||||
DOID:83 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5227) | ||||||
Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 29 May 2013 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | Y53C10A.12 | |||||||
Corresponding_transcript (2) | |||||||||
Other_sequence (32) | |||||||||
Associated_feature | WBsf665013 | ||||||||
WBsf717585 | |||||||||
WBsf978924 | |||||||||
WBsf985423 | |||||||||
WBsf220382 | |||||||||
Gene_product_binds | WBsf919560 | ||||||||
WBsf919561 | |||||||||
WBsf919565 | |||||||||
WBsf919566 | |||||||||
WBsf919567 | |||||||||
WBsf919568 | |||||||||
WBsf919569 | |||||||||
WBsf919570 | |||||||||
WBsf919571 | |||||||||
Transcription_factor | WBTranscriptionFactor000178 | ||||||||
Experimental_info (11) | |||||||||
Map_info | Map | I | Position | 13.0131 | Error | 0.000976 | |||
Positive | Positive_clone | Y53C10A | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4416 | |||||||
5648 | |||||||||
Reference (373) | |||||||||
Method | Gene |