WormBase Tree Display for Gene: WBGene00000857
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WBGene00000857 | SMap | S_parent | Sequence | K10B4 | |||
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Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cwn | ||||||
Allele (39) | |||||||
Legacy_information | [Shivakumar S, Jongeward G] early embryonic arrest. psoralen screen for lethals rescued by transgene including R180. encodes CeWnt1, a C. elegans wnt homolog. | ||||||
[C.elegansII] mu109 : embryonic lethal, early arrest as disorganized embryo at 2-3 fold stage; allele obtained by psoralen screen for lethals rescued by cwn-1 transgene. OA1: mu110.Cloned: 1.4 kb transcript, transspliced; most abundant in embryo; encodes 372 aa Wnt homolog[Shackleford et al. 1993; CF] | |||||||
Strain (21) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00044720 | ||||||
00044721 | |||||||
00044722 | |||||||
00044723 | |||||||
00044724 | |||||||
00044725 | |||||||
00044726 | |||||||
00044727 | |||||||
00044728 | |||||||
00044729 | |||||||
00044730 | |||||||
00044731 | |||||||
00044732 | |||||||
00044733 | |||||||
00044734 | |||||||
00044735 | |||||||
00044736 | |||||||
00044737 | |||||||
00044738 | |||||||
00044739 | |||||||
00044740 | |||||||
00044741 | |||||||
00044742 | |||||||
00044743 | |||||||
00044744 | |||||||
00044745 | |||||||
00044746 | |||||||
00044747 | |||||||
00044748 | |||||||
00044749 | |||||||
00044750 | |||||||
00044751 | |||||||
00044752 | |||||||
00044753 | |||||||
00044754 | |||||||
00044755 | |||||||
00044756 | |||||||
00044757 | |||||||
00044758 | |||||||
00044759 | |||||||
00044760 | |||||||
00044761 | |||||||
00044762 | |||||||
00044763 | |||||||
00044764 | |||||||
00044765 | |||||||
00044766 | |||||||
00044767 | |||||||
00044768 | |||||||
00105605 | |||||||
00105607 | |||||||
00105612 | |||||||
00107898 | |||||||
00107899 | |||||||
00107900 | |||||||
00107901 | |||||||
Ortholog (41) | |||||||
Paralog | WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000858 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | cwn-1 encodes one of five C. elegans Wnt signaling ligands; during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages. | Paper_evidence | WBPaper00001170 | |||
WBPaper00001743 | |||||||
WBPaper00025032 | |||||||
Curator_confirmed (3) | |||||||
Date_last_updated | 27 Apr 2009 00:00:00 | ||||||
Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in extracellular space. Expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism and endometrial carcinoma. Is an ortholog of human WNT4 (Wnt family member 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||
DOID:0111526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||||
Molecular_info | Corresponding_CDS | K10B4.6a | |||||
Corresponding_CDS_history | K10B4.6b:wp247 | ||||||
Corresponding_transcript | K10B4.6b | ||||||
K10B4.6a.1 | |||||||
Other_sequence (37) | |||||||
Associated_feature | WBsf649804 | ||||||
WBsf986332 | |||||||
WBsf1011348 | |||||||
WBsf222564 | |||||||
WBsf222565 | |||||||
WBsf222566 | |||||||
WBsf222567 | |||||||
Experimental_info | RNAi_result (30) | ||||||
Expr_pattern (20) | |||||||
Drives_construct (20) | |||||||
Construct_product (15) | |||||||
Microarray_results (23) | |||||||
Expression_cluster (160) | |||||||
Interaction (67) | |||||||
WBProcess | WBbiopr:00000017 | ||||||
WBbiopr:00000023 | |||||||
WBbiopr:00000073 | |||||||
Map_info | Map | II | Position | -15.9676 | Error | 0.013997 | |
Positive | Positive_clone | K10B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
R180 | |||||||
Mapping_data | Multi_point | 4244 | |||||
Pseudo_map_position | |||||||
Reference (89) | |||||||
Remark | replaces int-12, pcr clone isolated by Sasha Kamb. the accession numbers for these genes X72941 cwn-1 mRNA X72942 cwn-1 gene (introns included) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |