WormBase Tree Display for Gene: WBGene00000419

WBGene00000419 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: ced-5 Person_evidence: WBPerson261
      Sequence_name: C02F4.1
      Molecular_name: C02F4.1
        C02F4.1.1
        CE24779
      Other_name: CELE_C02F4.1 Accession_evidence: NDB BX284604
      Public_name: ced-5
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ced
    Allele (106)
    Legacy_information: [C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel.[Ellis et al. 1991; MT; NF; ZB]
      [C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel. [Ellis et al. 1991; MT; NF; ZB]
      [Wu Y-C, Horvitz HR] Encodes 1781 aa predicted protein with similarity to human protein DOCK180. n1812 is stop at codon 28, n2002, n2691 also nonsense mutations, m2098, n2099 are splice acceptor mutations. n1812/sDf2 resemble n1812/n1812, probable null phenotype. Predicted gene C02F4.1
    Strain: WBStrain00027132
      WBStrain00027134
      WBStrain00027167
      WBStrain00027174
      WBStrain00027281
      WBStrain00027282
      WBStrain00027293
      WBStrain00027342
      WBStrain00031450
    RNASeq_FPKM (74)
    GO_annotation: 00016615
      00016616
      00016617
      00016618
      00016619
      00016620
      00016621
      00016622
      00016623
      00016624
      00016625
      00016626
      00016627
      00016628
      00016629
      00016630
      00016631
      00016632
      00016633
      00016634
      00016635
      00016636
      00016637
      00016638
      00016639
      00016640
      00016641
      00016642
      00016643
      00016644
      00016645
      00016646
      00016647
      00016648
      00016649
      00016650
      00016651
      00016652
      00016653
      00016654
      00016655
      00016656
      00016657
      00016658
      00016659
      00016660
      00107374
      00107375
    Ortholog (59)
    Paralog: WBGene00009065 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018520 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ced-5 encodes a homolog of the human protein DOCK180; ced-5 is required for the cell engulfment stage of programmed cell death, and physically interacts with CED-2. Paper_evidence: WBPaper00003036
            WBPaper00003948
            WBPaper00005004
            WBPaper00012851
            WBPaper00013593
            WBPaper00013632
            WBPaper00038460
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 29 Jun 2012 00:00:00
      Automated_description: Enables SH3 domain binding activity and enzyme binding activity. Involved in several processes, including left/right axis specification; positive regulation of distal tip cell migration; and vesicle-mediated transport. Located in presynapse. Part of guanyl-nucleotide exchange factor complex. Expressed in body wall muscle cell; hermaphrodite somatic gonadal cell; and intestinal cell. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and immunodeficiency 40. Is an ortholog of human DOCK2 (dedicator of cytokinesis 2) and DOCK5 (dedicator of cytokinesis 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111951 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2988)
      DOID:1094 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2989)
  Molecular_info: Corresponding_CDS: C02F4.1
    Corresponding_transcript: C02F4.1.1
    Other_sequence (13)
    Associated_feature: WBsf646307
      WBsf660584
      WBsf976954
      WBsf976955
      WBsf976956
      WBsf228996
      WBsf228997
      WBsf228998
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr8762
      Expr14253
      Expr1020545
      Expr1030235
      Expr1143552
      Expr2009849
      Expr2028089
    Drives_construct: WBCnstr00005770
      WBCnstr00037557
      WBCnstr00040684
    Construct_product: WBCnstr00014899
      WBCnstr00037557
    Microarray_results (24)
    Expression_cluster (132)
    Interaction (129)
    WBProcess: WBbiopr:00000013
      WBbiopr:00000014
      WBbiopr:00000015
      WBbiopr:00000023
      WBbiopr:00000107
  Map_info: Map: IV Position: 4.61067 Error: 0.002681
    Well_ordered
    Positive: Positive_clone: C02F4 Inferred_automatically: From sequence, transcript, pseudogene data
        ZK188
    Mapping_data: Multi_point: 1517
        1518
        1520
        1521
        1522
        1523
        1820
        1822
        4720
      Pos_neg_data: 4243
  Reference: WBPaper00001438
    WBPaper00001487
    WBPaper00001491
    WBPaper00001529
    WBPaper00001642
    WBPaper00001728
    WBPaper00002172
    WBPaper00002212
    WBPaper00002388
    WBPaper00002422
    WBPaper00002437
    WBPaper00002592
    WBPaper00002867
    WBPaper00002891
    WBPaper00003036
    WBPaper00003074
    WBPaper00003090
    WBPaper00003091
    WBPaper00003301
    WBPaper00003451
    WBPaper00003627
    WBPaper00003706
    WBPaper00003914
    WBPaper00003948
    WBPaper00003957
    WBPaper00003990
    WBPaper00004218
    WBPaper00004462
    WBPaper00004503
    WBPaper00004564
    WBPaper00004751
    WBPaper00004883
    WBPaper00004897
    WBPaper00004958
    WBPaper00005085
    WBPaper00005196
    WBPaper00005200
    WBPaper00005291
    WBPaper00005495
    WBPaper00005538
    WBPaper00005555
    WBPaper00005857
    WBPaper00005868
    WBPaper00005874
    WBPaper00005898
    WBPaper00006008
    WBPaper00006212
    WBPaper00006383
    WBPaper00006385
    WBPaper00010011
    WBPaper00010012
    WBPaper00010143
    WBPaper00010266
    WBPaper00010395
    WBPaper00010416
    WBPaper00010475
    WBPaper00010710
    WBPaper00010959
    WBPaper00010999
    WBPaper00011043
    WBPaper00011045
    WBPaper00011183
    WBPaper00011213
    WBPaper00011219
    WBPaper00011964
    WBPaper00011990
    WBPaper00012417
    WBPaper00012463
    WBPaper00012690
    WBPaper00013103
    WBPaper00013238
    WBPaper00013347
    WBPaper00014018
    WBPaper00014072
    WBPaper00015205
    WBPaper00016901
    WBPaper00017041
    WBPaper00017692
    WBPaper00017884
    WBPaper00017887
    WBPaper00017888
    WBPaper00018102
    WBPaper00018248
    WBPaper00018249
    WBPaper00018342
    WBPaper00018584
    WBPaper00019400
    WBPaper00019552
    WBPaper00020924
    WBPaper00021687
    WBPaper00021737
    WBPaper00021969
    WBPaper00022068
    WBPaper00022142
    WBPaper00022326
    WBPaper00022448
    WBPaper00022504
    WBPaper00022509
    WBPaper00022829
    WBPaper00022912
    WBPaper00022914
    WBPaper00023566
    WBPaper00024057
    WBPaper00024058
    WBPaper00024059
    WBPaper00024253
    WBPaper00024474
    WBPaper00024670
    WBPaper00024942
    WBPaper00024961
    WBPaper00025002
    WBPaper00025003
    WBPaper00025306
    WBPaper00025454
    WBPaper00025757
    WBPaper00025964
    WBPaper00025999
    WBPaper00026343
    WBPaper00026487
    WBPaper00026588
    WBPaper00026772
    WBPaper00026923
    WBPaper00027291
    WBPaper00027296
    WBPaper00027398
    WBPaper00027648
    WBPaper00027659
    WBPaper00027834
    WBPaper00028966
    WBPaper00029018
    WBPaper00029147
    WBPaper00029228
    WBPaper00030410
    WBPaper00030415
    WBPaper00030417
    WBPaper00030424
    WBPaper00030433
    WBPaper00030738
    WBPaper00030766
    WBPaper00031470
    WBPaper00031612
    WBPaper00031730
    WBPaper00031731
    WBPaper00031753
    WBPaper00031805
    WBPaper00031858
    WBPaper00032003
    WBPaper00032272
    WBPaper00032446
    WBPaper00033098
    WBPaper00033674
    WBPaper00034773
    WBPaper00034913
    WBPaper00035198
    WBPaper00035284
    WBPaper00035874
    WBPaper00035888
    WBPaper00035978
    WBPaper00036252
    WBPaper00036351
    WBPaper00036496
    WBPaper00037284
    WBPaper00038317
    WBPaper00038341
    WBPaper00038460
    WBPaper00038491
    WBPaper00039499
    WBPaper00039521
    WBPaper00040757
    WBPaper00041117
    WBPaper00041162
    WBPaper00041221
    WBPaper00041307
    WBPaper00041869
    WBPaper00042061
    WBPaper00042428
    WBPaper00043289
    WBPaper00043689
    WBPaper00044144
    WBPaper00046300
    WBPaper00050403
    WBPaper00050421
    WBPaper00050503
    WBPaper00051118
    WBPaper00055071
    WBPaper00055090
    WBPaper00057060
    WBPaper00061198
    WBPaper00063042
    WBPaper00064325
    WBPaper00064400
  Method: Gene