WormBase Tree Display for Gene: WBGene00001898

WBGene00001898 SMap: S_parent: Sequence: M163
  Identity: Version: 2
    Name: CGC_name: his-24 Person_evidence: WBPerson160
      Sequence_name: M163.3
      Molecular_name: M163.3
        M163.3.1
        CE12450
      Other_name: HH1
        H1.1 Paper_evidence: WBPaper00004630
        Histone H1.1 Paper_evidence: WBPaper00053345
        CELE_M163.3 Accession_evidence: NDB BX284606
      Public_name: his-24
    DB_info: Database: AceView gene XP109
        WormQTL gene WBGene00001898
        WormFlux gene WBGene00001898
        NDB locus_tag CELE_M163.3
        Panther gene CAEEL|WormBase=WBGene00001898|UniProtKB=P10771
          family PTHR11467
        NCBI gene 181545
        RefSeq protein NM_078009.7
        SwissProt UniProtAcc P10771
        UniProt_GCRP UniProtAcc P10771
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele (33)
    Legacy_information: [C.elegansII] NMK. Histone type H1. Contains intron, encodes polyadenylated RNA. [Sanicola et al. 1990]
    Strain: WBStrain00031772
      WBStrain00034782
      WBStrain00034807
      WBStrain00006458
    RNASeq_FPKM (74)
    GO_annotation: 00039072
      00039073
      00039074
      00039075
      00039076
      00039077
      00039078
      00039079
      00039080
      00039081
      00039082
      00039083
      00039084
      00039085
      00039086
      00039087
      00039088
      00039089
      00039090
      00039091
      00039092
      00039093
      00039094
      00039095
      00039096
      00039097
      00109613
      00109614
      00109615
      00109616
    Ortholog: WBGene00040348 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
      WBGene00058501 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148070 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132085 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00121502 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00091178 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00068514 Caenorhabditis remanei From_analysis: OMA
            WormBase-Compara
      WBGene00103491 Pristionchus pacificus From_analysis: OMA
      WBGene00175902 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00029507 Caenorhabditis briggsae From_analysis: Inparanoid_8
      WBGene00040335 Caenorhabditis briggsae From_analysis: Inparanoid_8
      CSP21.g9577 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1242 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11747 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g2213 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17283 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g20878 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22029 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g22030 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7903 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g16235 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g3274 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g3275 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g4739 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g26055 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g27654 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10318 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_01052.g15504 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_04440.g18852 Caenorhabditis angaria From_analysis: WormBase-Compara
      Csp11.Scaffold564.g4009 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10190 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g11881 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01786.g23127 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01642 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_05582 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_012323 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012373 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012414 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012441 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_025690 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14413 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g9555 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0147600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20593 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00126857 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00070150 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00072146 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00076741 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00278528 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00278880 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257204 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000006048 Saccharomyces cerevisiae From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      FB:FBgn0051617 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053807 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053861 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053852 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053816 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053804 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053813 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053810 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053828 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053834 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053849 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053819 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053855 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053843 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053801 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053831 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053837 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053840 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053864 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053858 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053822 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053846 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053825 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-030131-337 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
      HGNC:4714 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
      HGNC:18463 Homo sapiens From_analysis: OrthoFinder
            Panther
            SonicParanoid
      MGI:95893 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
      RGD:2777 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
    Paralog: WBGene00001852 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001853 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001854 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001856 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001857 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: his-24 encodes one of eight C. elegans H1 linker histones; HIS-24, along with the histone deacetylase SIR-2.1 and the Enhancer of zeste E(Z) ortholog MES-2, plays a key role in heterochromatin regulation and thus, in regulation of fertility and embryonic development; specifically, HIS-24 and SIR-2.1 are essential for maintenance of the histone H3K27me3 mark at subtelomeric regions in the C. elegans germ line; HIS-24 interacts specifically with the H3 K27 region, either when unmodified or when in the trimethylated (me3) state; HIS-24 is ubiquitously expressed and localizes to nuclei; in addition, in germ cells, the majority of HIS-24 localizes to the cytoplasm, in a manner dependent upon SIR-2.1 and MES proteins. Paper_evidence: WBPaper00004630
            WBPaper00028983
            WBPaper00033091
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Nov 2010 00:00:00
      Automated_description: Enables H3K27me3 modified histone binding activity. Involved in defense response to Gram-positive bacterium and negative regulation of gene expression. Located in chromosome, telomeric region; cytoplasm; and nucleus. Expressed in several structures, including germ line and gonad. Is an ortholog of human H1-0 (H1.0 linker histone) and H1-8 (H1.8 linker histone). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: M163.3
    Corresponding_transcript: M163.3.1
    Other_sequence (76)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00090698 Inferred_automatically: RNAi_primary
      WBRNAi00017226 Inferred_automatically: RNAi_primary
      WBRNAi00089638 Inferred_automatically: RNAi_primary
      WBRNAi00027719 Inferred_automatically: RNAi_primary
      WBRNAi00089608 Inferred_automatically: RNAi_primary
      WBRNAi00050989 Inferred_automatically: RNAi_primary
      WBRNAi00076026 Inferred_automatically: RNAi_primary
      WBRNAi00076031 Inferred_automatically: RNAi_primary
      WBRNAi00064599 Inferred_automatically: RNAi_primary
      WBRNAi00076030 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00000408
      WBCnstr00000430
      WBCnstr00002522
      WBCnstr00007280
      WBCnstr00009451
      WBCnstr00013533
      WBCnstr00015453
      WBCnstr00015912
      WBCnstr00036616
    Construct_product (293)
    Regulate_expr_cluster: WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
    Antibody: WBAntibody00000355
      WBAntibody00001210
      WBAntibody00002298
    Microarray_results (26)
    Expression_cluster (392)
    Interaction (157)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: X Position: 16.7093 Error: 0.005353
    Positive: Positive_clone: LCEH1A
        M163 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene