WormBase Tree Display for Gene: WBGene00000156
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WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | apr | ||||||
Allele (69) | |||||||
Possibly_affected_by | WBVar02153202 | ||||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||
Strain | WBStrain00037280 | ||||||
WBStrain00000140 | |||||||
WBStrain00008585 | |||||||
WBStrain00024309 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00002491 | ||||||
00002492 | |||||||
00002493 | |||||||
00002494 | |||||||
00002495 | |||||||
00070802 | |||||||
00070803 | |||||||
00070804 | |||||||
00070805 | |||||||
00070806 | |||||||
00070807 | |||||||
00070808 | |||||||
00070809 | |||||||
00070810 | |||||||
00070811 | |||||||
00070812 | |||||||
00070813 | |||||||
00070814 | |||||||
00070815 | |||||||
00070816 | |||||||
00070817 | |||||||
00070818 | |||||||
00070819 | |||||||
00070820 | |||||||
00070821 | |||||||
00070822 | |||||||
00070823 | |||||||
00070824 | |||||||
00070825 | |||||||
00070826 | |||||||
00070827 | |||||||
00070828 | |||||||
00070829 | |||||||
00070830 | |||||||
00070831 | |||||||
00070832 | |||||||
00070833 | |||||||
00070834 | |||||||
00070835 | |||||||
00070836 | |||||||
00070837 | |||||||
00070838 | |||||||
00070839 | |||||||
00070840 | |||||||
00070841 | |||||||
00070842 | |||||||
00070843 | |||||||
00070844 | |||||||
00070845 | |||||||
00070846 | |||||||
00070847 | |||||||
00070848 | |||||||
00070849 | |||||||
00070850 | |||||||
00070851 | |||||||
00070852 | |||||||
00070853 | |||||||
00070854 | |||||||
00070855 | |||||||
00070856 | |||||||
00070857 | |||||||
00070858 | |||||||
00070859 | |||||||
00070860 | |||||||
00070861 | |||||||
00070862 | |||||||
00070863 | |||||||
00070864 | |||||||
00070865 | |||||||
00070866 | |||||||
00070867 | |||||||
00070868 | |||||||
00070869 | |||||||
00070870 | |||||||
00070871 | |||||||
00106884 | |||||||
00106885 | |||||||
Ortholog (41) | |||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (20) | ||||||
Molecular_info | Corresponding_CDS | K04G2.8a | |||||
K04G2.8b | |||||||
K04G2.8c | |||||||
Corresponding_transcript | K04G2.8a.1 | ||||||
K04G2.8b.1 | |||||||
K04G2.8c.1 | |||||||
Other_sequence | AF013950 | ||||||
CGC00612_1 | |||||||
ACC25655_1 | |||||||
EX555243.1 | |||||||
CBC06635_1 | |||||||
Associated_feature | WBsf656598 | ||||||
WBsf218114 | |||||||
Experimental_info | RNAi_result (104) | ||||||
Expr_pattern | Expr1046 | ||||||
Expr4600 | |||||||
Expr12119 | |||||||
Expr12448 | |||||||
Expr15118 | |||||||
Expr1028112 | |||||||
Expr1030085 | |||||||
Expr1153646 | |||||||
Expr2009365 | |||||||
Expr2027601 | |||||||
Drives_construct | WBCnstr00005188 | ||||||
WBCnstr00007256 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00009116 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Construct_product | WBCnstr00000526 | ||||||
WBCnstr00007257 | |||||||
WBCnstr00007258 | |||||||
WBCnstr00009057 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Antibody | WBAntibody00000276 | ||||||
WBAntibody00000277 | |||||||
Microarray_results | SMD_K04G2.8 | ||||||
188110_s_at | |||||||
A_12_P112368 | |||||||
A_12_P146065 | |||||||
A_12_P146066 | |||||||
Aff_K04G2.8A | |||||||
GPL13394_WBGene00000156 | |||||||
GPL13914_K04G2.8 | |||||||
GPL14144_K04G2.8b_2977-3036_0.921_9_C | |||||||
GPL14144_K04G2.8b_3086-3145_0.929_6_B | |||||||
GPL14144_K04G2.8b_3301-3360_0.942_1_A | |||||||
GPL19516_CGZ0027849 | |||||||
GPL19516_CGZ0027850 | |||||||
GPL21109_K04G2.8a | |||||||
GPL3518_CE18016 | |||||||
GPL8304_CE_WBGene00000156_A | |||||||
GPL8304_CE_WBGene00000156_B | |||||||
GPL8673_K04G2_8aP02095 | |||||||
GPL8673_K04G2_8aP02640 | |||||||
GPL8673_K04G2_8aP03192 | |||||||
GPL8673_K04G2_8bP02101 | |||||||
GPL8673_K04G2_8bP02646 | |||||||
GPL8673_K04G2_8bP03198 | |||||||
GPL9450_K04G2.8a | |||||||
cea2.d.32222 | |||||||
Expression_cluster (124) | |||||||
Interaction (179) | |||||||
WBProcess | WBbiopr:00000073 | ||||||
Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |
Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4159 | |||||
4893 | |||||||
5616 | |||||||
Pseudo_map_position | |||||||
Reference (108) | |||||||
Picture | WBPicture0000013084 | ||||||
Remark | Data extracted from Rocheleau et al. (1997) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |