| WBGene00022500 | Evidence | Paper_evidence | WBPaper00013452 |
|---|
| SMap | S_parent | Sequence | ZC8 |
| Identity | Version | 2 |
| | Name (5) |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 04 Jun 2004 10:29:58 | WBPerson1971 | Name_change | CGC_name | lfi-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lfi |
| | Allele (252) |
| | Strain | WBStrain00032313 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00023076 |
| | | 00023077 |
| | Ortholog (43) |
| | Paralog | WBGene00018051 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | lfi-1 encodes, by alternative splicing, at least four isoforms of alarge coiled-coil protein paralogous to F35D11.11, and possiblyorthologous to rootletin (the structural protein comprising ciliaryrootlets); LFI-1 is also homologous to the Parascaris univalens MitoticAntigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known. | Paper_evidence | WBPaper00024244 |
| | | | | | WBPaper00029004 |
| | | | | | WBPaper00029016 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 07 Feb 2007 00:00:00 |
| | | Automated_description | Located in kinetochore microtubule and nucleus. Is an ortholog of human CROCC (ciliary rootlet coiled-coil, rootletin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | EFO:0009151 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1859) |
| Molecular_info | Corresponding_CDS | ZC8.4a |
| | | ZC8.4d |
| | | ZC8.4e |
| | | ZC8.4f |
| | | ZC8.4g |
| | | ZC8.4h |
| | Corresponding_CDS_history | ZC8.4b:wp145 |
| | | ZC8.4b:wp272 |
| | | ZC8.4c:wp145 |
| | | ZC8.4d:wp272 |
| | | ZC8.4e:wp272 |
| | Corresponding_transcript | ZC8.4a.1 |
| | | ZC8.4a.2 |
| | | ZC8.4a.3 |
| | | ZC8.4a.4 |
| | | ZC8.4d.1 |
| | | ZC8.4e.1 |
| | | ZC8.4f.1 |
| | | ZC8.4g.1 |
| | | ZC8.4h.1 |
| | Other_sequence (219) |
| | Associated_feature | WBsf648060 |
| | | WBsf648061 |
| | | WBsf978486 |
| | | WBsf1005147 |
| | | WBsf1005148 |
| | | WBsf1022896 |
| | | WBsf235646 |
| | | WBsf235647 |
| | | WBsf235648 |
| | Transcription_factor | WBTranscriptionFactor000405 |
| Experimental_info | RNAi_result (10) |
| | Expr_pattern | Expr2936 |
| | | Expr1013576 |
| | | Expr1039943 |
| | | Expr1162452 |
| | | Expr2013090 |
| | | Expr2031322 |
| | Drives_construct | WBCnstr00024200 |
| | Construct_product | WBCnstr00024200 |
| | | WBCnstr00038856 |
| | Antibody | WBAntibody00000895 |
| | | WBAntibody00001192 |
| | Microarray_results (48) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00028867:HLH-1_induced_TF |
| | | WBPaper00031040:Cluster_5 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00040965:top50_lipid-droplet_associated_protein |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:DAF-16_upregulated |
| | | WBPaper00049368:daf-2(e1370)_upregulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049635:dop-1(vs100)_downregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051352:Long-Term-Association-Memory_downregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00051555:atm-1(gk186)_regulated_protein |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:sod-2(ok1030)_downregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056284:ints-1(RNAi)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056446:hsb-1(cg116)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059604:fluvastatin_upregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_upregulated_N2 |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(overexpression)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060921:cat-2(e1112)_downregulated |
| | | WBPaper00060921:tdc-1(n3419)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:Anterior_arcade_cell |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:URX |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:saeg-1_18803-mpz-2_15880 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064952:Day5_vs_L4_upregulated_25C |
| | | WBPaper00064952:Day10_vs_L4_upregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_upregulated_25C |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_5_6 |
| | | cgc4489_group_17 |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00028474:dys-1_downregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038462:aging_downregulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | Interaction (51) |
| Map_info | Map | X | Position | -6.19862 | Error | 0.000328 |
| | Positive | Positive_clone | ZC8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00010599 |
| | WBPaper00018632 |
| | WBPaper00023417 |
| | WBPaper00024244 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
