Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00017920

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00017920SMapS_parentSequenceF29B9
IdentityVersion2
NameCGC_namejmjd-1.2Person_evidenceWBPerson260
Sequence_nameF29B9.2
Molecular_nameF29B9.2a
F29B9.2a.1
CE09781
F29B9.2b
CE27145
F29B9.2c
CE48643
F29B9.2b.1
F29B9.2c.1
Other_nameCeKDM7APaper_evidenceWBPaper00040011
CELE_F29B9.2Accession_evidenceNDBBX284604
Public_namejmjd-1.2
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change (2)
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classjmjd
Allele (59)
StrainWBStrain00037581
RNASeq_FPKM (74)
GO_annotation (31)
Contained_in_operonCEOP4136
Ortholog (45)
ParalogWBGene00005013Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00020821Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionjmjd-1.2 encodes a PHD and JmjC domain-containing histone demethylase that is homologous to human PHF8, mutations in which are associated with mild X-linked mental retardation (XLMR) and cleft/lip palate; JMJD-1.2 exhibits H3K9me2 and H3K27me2 demethylase activity in vitro and loss-of-function mutations in jmjd-1.2 result in increased levels of H3K9me2 and H3K27me2 in protein lysates from mutant animals; jmjd-1.2 mutant animals also exhibit locomotion defects with increased wavelength, but normal amplitude, of sinusoidal movement; a jmjd-1.2::GFP fusion protein is strongly expressed in neurons where it localizes to the nucleus; fainter expression is also seen in muscle, intestine, and hypodermal cells; jmjd-1.2 expression in neurons is sufficient to rescue the locomotion defects.Paper_evidenceWBPaper00036110
Curator_confirmedWBPerson1843
Date_last_updated08 Apr 2010 00:00:00
Automated_descriptionEnables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Expressed in several structures, including germ cell; hypodermis; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma; prostate cancer; and syndromic X-linked intellectual disability Siderius type. Is an ortholog of human KDM7A (lysine demethylase 7A).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0060309Homo sapiensPaper_evidenceWBPaper00050709
Curator_confirmedWBPerson324
Date_last_updated13 Nov 2017 00:00:00
Potential_modelDOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20672)
DOID:1909Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:22224)
DOID:0060812Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20672)
Models_disease_assertedWBDOannot00000447
Molecular_infoCorresponding_CDSF29B9.2a
F29B9.2b
F29B9.2c
Corresponding_transcriptF29B9.2a.1
F29B9.2b.1
F29B9.2c.1
Other_sequence (65)
Associated_featureWBsf047593
WBsf047594
WBsf645943
WBsf977089
WBsf996358
WBsf228223
WBsf228224
Experimental_infoRNAi_result (11)
Expr_patternExpr13259
Expr13525
Expr1021912
Expr1037705
Expr1149803
Expr2012886
Expr2031120
Drives_constructWBCnstr00026915
Construct_productWBCnstr00026915
Regulate_expr_clusterWBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:rgef-1pjmjd-1.2(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050709:jmjd-1.2(tm3713)_regulated
WBPaper00062156:jmjd-1.2(zr1010)_downregulated
WBPaper00062156:jmjd-1.2(zr1010)_upregulated
WBPaper00066083:hlh-17p-jmjd-1.2_downregulated
WBPaper00066083:hlh-17p-jmjd-1.2_upregulated
AntibodyWBAntibody00002197
WBAntibody00002746
Microarray_results (27)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00037682:sma-2_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048988:neuron_expressed
WBPaper00049159:Microwave_upregulated_adult
WBPaper00049498:npr-1(ur89)_regulated_8
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00054571:BPA_F3_germline_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056826:SGP_biased
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:npp-6-mtr-4_21425
WBPaper00062156:jmjd-1.2(zr1010)_downregulated
WBPaper00063930:BRD-1_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
WBPaper00066083:hlh-17p-jmjd-1.2_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_6_2
WBPaper00025032:cluster_109
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00035905:FBF-1_Associated
WBPaper00036429:glp-1(oz112)_upregulated
WBPaper00037113:CPF_DZN_16C_up-regulated
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045263:0.1mM-paraquat_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(122_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_ME
[cgc6390]:intrinsic
Interaction (18)
Map_infoMapIVPosition0.6425Error0.013666
PositivePositive_cloneF29B9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (18)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene