WBGene00014025 | SMap | S_parent | Sequence | ZK637 |
| Identity | Version | 3 |
| | Name | CGC_name | asna-1 | Paper_evidence | WBPaper00029101 |
| | | | | Person_evidence | WBPerson304 |
| | | | | | WBPerson664 |
| | | Sequence_name | ZK637.5 |
| | | Molecular_name | ZK637.5 |
| | | | ZK637.5.1 |
| | | | CE00436 |
| | | Other_name | tag-205 | Person_evidence | WBPerson201 |
| | | | CELE_ZK637.5 | Accession_evidence | NDB | BX284603 |
| | | Public_name | asna-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 22 Dec 2004 16:59:41 | WBPerson2970 | Name_change | CGC_name | tag-205 |
| | | | 3 | 16 Feb 2007 14:39:36 | WBPerson2970 | Name_change | CGC_name | asna-1 |
| | | | | | | | Other_name | tag-205 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | asna |
| | Allele (25) |
| | Strain | WBStrain00035475 |
| | | WBStrain00035956 |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Contained_in_operon | CEOP3552 |
| | Ortholog (37) |
| | Paralog | WBGene00014987 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes |
| | Structured_description | Concise_description | asna-1 encodes a putative membrane transporter that is required,non-cell-autonomously, for L1 larvae to proceed through development whenfed, and is also required for normal insulin (DAF-28) secretion; thehuman ASNA1 ortholog stimulates insulin secretion in pancreatic betacells, and can transgenically rescue asna-1 mutant C. elegans,suggesting that ASNA-1's function is conserved among metazoa; asna-1mutants only progress to adulthood when rescued by maternal ASNA-1;without maternal rescue, asna-1 mutants eat food and endocytosenutrients normally, but nevertheless arrest growth as L1 larvae andlocalize DAF-16 to the nucleus as if food were absent; asna-1 isexpressed in some sensory neurons, in insulin-producing intestinalcells, and in hypodermis; ASNA-1 positively regulates dauer exit in thesame way that overexpression of the insulins DAF-28 or INS-4 does, andrequires DAF-28 to do this efficiently; ASNA-1 has ATPase activity invitro, and this activity is required for transgenic rescue of asna-1mutations. | Paper_evidence | WBPaper00029101 |
| | | | | | WBPaper00029103 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 18 Feb 2007 00:00:00 |
| | | Automated_description | Enables ATP hydrolysis activity. Involved in detoxification of arsenic-containing substance and positive regulation of insulin secretion. Located in axon and neuronal cell body. Expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Used to study cancer. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is an ortholog of human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00061328 |
| | | | | | WBPaper00037696 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Oct 2021 00:00:00 |
| | Potential_model | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:752) |
| Models_disease_asserted | WBDOannot00001066 |
| | WBDOannot00001067 |
| Molecular_info | Corresponding_CDS | ZK637.5 |
| | Corresponding_transcript | ZK637.5.1 |
| | Other_sequence (83) |
| | Associated_feature | WBsf034286 |
| | | WBsf993507 |
| | | WBsf993508 |
| | | WBsf1015509 |
| | | WBsf1015510 |
| | | WBsf225487 |
| Experimental_info | RNAi_result | WBRNAi00103076 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005059 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00103074 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00103075 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00038387 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00103072 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059596 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00000434 |
| | | WBCnstr00002653 |
| | | WBCnstr00004628 |
| | | WBCnstr00004629 |
| | | WBCnstr00012077 |
| | | WBCnstr00029370 |
| | Construct_product (5) |
| | Regulate_expr_cluster | WBPaper00065132:asna-1(ok938)_downregulated_protein |
| | | WBPaper00065132:asna-1(ok938)_upregulated_protein |
| | Antibody | WBAntibody00001229 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040412:germline-regulated_daf-16_target |
| | | WBPaper00040990:PA14_upregulated |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050015:ifg-1(RNAi)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061340:AUA |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064992:heat-shock_upregulated |
| | | cgc4386_cluster_5_3 |
| | | cgc4489_group_1 |
| | | WBPaper00025032:cluster_13 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (105) |
| | Anatomy_function | WBbtf0042 |
| | | WBbtf0043 |
| | | WBbtf0044 |
| | | WBbtf0045 |
| Map_info | Map | III | Position | -0.009601 | Error | 0.001135 |
| | Positive | Positive_clone | ZK637 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4957 |
| | Pseudo_map_position |
| Reference (20) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |