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WormBase Tree Display for Gene: WBGene00013866

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Name Class

WBGene00013866SMapS_parentSequenceCHROMOSOME_X
IdentityVersion2
NameCGC_namecbs-1Paper_evidenceWBPaper00039977
Person_evidenceWBPerson537
Sequence_nameZC373.1
Molecular_nameZC373.1a
ZC373.1a.1
CE31670
ZC373.1b
CE47092
ZC373.1b.1
Other_nameCELE_ZC373.1Accession_evidenceNDBBX284606
Public_namecbs-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:55WBPerson1971EventImportedInitial conversion from CDS class of WS125
229 Sep 2011 10:45:56WBPerson2970Name_changeCGC_namecbs-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcbs
Allele (32)
StrainWBStrain00002826
WBStrain00052082
RNASeq_FPKM (74)
GO_annotation (16)
Ortholog (40)
Paralog (12)
Structured_descriptionConcise_descriptioncbs-1 encodes an ortholog of human CYSTATHIONINE-BETA-SYNTHASE (CBS), which when mutated leads to homocystinuria (OMIM:236200).Paper_evidenceWBPaper00004637
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables cystathionine beta-synthase activity; cysteine synthase activity; and pyridoxal phosphate binding activity. Involved in sulfur compound biosynthetic process. Located in cytoplasm. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including homocystinuria; hyperhomocysteinemia; and neural tube defect. Is an ortholog of human CBS (cystathionine beta-synthase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080074Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
DOID:12365Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
DOID:9279Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
DOID:9263Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
DOID:3526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
DOID:3393Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1550)
Molecular_infoCorresponding_CDSZC373.1a
ZC373.1b
Corresponding_CDS_historyZC373.1:wp83
Corresponding_transcriptZC373.1a.1
ZC373.1b.1
Other_sequence (40)
Associated_featureWBsf648441
WBsf655205
WBsf1006596
WBsf236234
Experimental_infoRNAi_resultWBRNAi00058845Inferred_automaticallyRNAi_primary
WBRNAi00091457Inferred_automaticallyRNAi_primary
Expr_pattern (8)
Drives_constructWBCnstr00003351
WBCnstr00014401
WBCnstr00029491
Construct_productWBCnstr00014401
WBCnstr00016327
WBCnstr00029491
AntibodyWBAntibody00002306
Microarray_results (22)
Expression_clusterWBPaper00029359_1217
WBPaper00029359_1280
WBPaper00029359_1353
WBPaper00029359_1419
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1548
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032425:up_in_alg-1
WBPaper00032425:up_in_zfp-1
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044426:rotenone_5day_downregulated
WBPaper00044578:4-day_reduced-humidity_upregulated_proteomics
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045316:prg-1_upregulated_L3
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045521:Oogenic
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046303:P.aeruginosa_upregulated_protein
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049217:DAF-16_upregulated
WBPaper00049495:starvation-refeeding_regulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051558:fog-2(q71)_regulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053792:Ochrobactrum_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056284:ints-1(RNAi)_downregulated
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00057154:HeatShock_downregulated_miRNA-target
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_protein
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059735:glucose_downregulated_N2
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:HB115_upregulated
WBPaper00061007:M.braciatum_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061340:Body_wall_muscle
WBPaper00061340:DVC_parent
WBPaper00061340:Neuroblast_PVC_LUA
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:dhs-28_22199-acs-14
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064122:vulva_transcriptome
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064728:cpl-1(W32AY35A)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00064992:Capsaicin_downregulated
WBPaper00064992:Eugenol_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066085:sin-3(tm1276)_upregulated
WBPaper00025032:cluster_7
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031850:mdt-15(RNAi)_upregulated
WBPaper00032165:A_to_C_transit_increased
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00032948:FedUp
WBPaper00034739:N2moreDR1350
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036286:Pattern_I
WBPaper00037695:LD_3-day
WBPaper00037695:WC_5-day
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00042204:Comamonas_DA1877_upregulated
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00042258:DA1877_upregulated_YoungAdult
WBPaper00047070:DAF-16-dependent_UV_response
WBPaper00048567:dnj-14_downregulated
WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
WBPaper00050538:Fasting_upregulated
WBPaper00050538:Fasting_upregulated_cholesterol-dependent
WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053827:pyoverdine_upregulated
[cgc5767]:cluster_4
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(122_min)
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
Interaction (63)
Map_infoMapXPosition1.73547
PositivePositive_cloneZC373Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00034443
WBPaper00038491
WBPaper00040475
WBPaper00040626
WBPaper00055090
WBPaper00059856
WBPaper00059949
WBPaper00060431
WBPaper00060693
WBPaper00064989
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene