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WormBase Tree Display for Gene: WBGene00012885

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Name Class

WBGene00012885SMapS_parentSequenceY45F10D
IdentityVersion2
Name (5)
DB_infoDatabaseAceViewgene4O549
WormQTLgeneWBGene00012885
WormFluxgeneWBGene00012885
NDBlocus_tagCELE_Y45F10D.4
PanthergeneCAEEL|WormBase=WBGene00012885|UniProtKB=O45948
familyPTHR10093
NCBIgene178344
RefSeqproteinNM_070257.4
TREEFAMTREEFAM_IDTF105422
TrEMBLUniProtAccO45948
UniProt_GCRPUniProtAccO45948
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:54WBPerson1971EventImportedInitial conversion from CDS class of WS125
214 Mar 2019 16:17:45WBPerson1983Name_changeCGC_nameiscu-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classiscu
Allele (19)
RNASeq_FPKM (74)
GO_annotation (11)
Ortholog (39)
Structured_descriptionConcise_descriptionY45F10D.4 encodes a putative iron-sulfur cluster assembly enzyme that is required for embryonic and larval viability, and that is orthologous to human NIFUN and budding yeast ISU1 and ISU2; Y45F10D.4 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults; by orthology with yeast ISU1, Y45F10D.4 is predicted to bind FRH-1.Paper_evidenceWBPaper00006395
WBPaper00025054
WBPaper00031448
WBPaper00031518
WBPaper00031519
WBPaper00031520
Curator_confirmedWBPerson567
Date_last_updated17 Feb 2008 00:00:00
Automated_descriptionPredicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in mitochondrial matrix. Expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and pre-eclampsia. Is an ortholog of human ISCU (iron-sulfur cluster assembly enzyme).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4467Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:29882)
DOID:10591Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:29882)
Molecular_infoCorresponding_CDSY45F10D.4
Corresponding_transcriptY45F10D.4.1
Other_sequence (68)
Associated_featureWBsf646539
WBsf019655
WBsf229458
Experimental_infoRNAi_resultWBRNAi00026708Inferred_automaticallyRNAi_primary
WBRNAi00037100Inferred_automaticallyRNAi_primary
WBRNAi00098387Inferred_automaticallyRNAi_primary
WBRNAi00088549Inferred_automaticallyRNAi_primary
WBRNAi00037096Inferred_automaticallyRNAi_primary
WBRNAi00056598Inferred_automaticallyRNAi_primary
WBRNAi00056603Inferred_automaticallyRNAi_primary
Expr_patternExpr15935
Expr15936
Expr1022523
Expr1035697
Expr1160071
Expr2007551
Expr2025787
Drives_constructWBCnstr00029801
WBCnstr00042612
Construct_productWBCnstr00029801
WBCnstr00042613
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035073:mitochondria_protein
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:SGP_biased
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061527:dld-1-skn-1_16701
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
WBPaper00064005:starvation_downregulated_N2_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_Ref
cgc4386_cluster_1_5
WBPaper00025032:cluster_173
WBPaper00025141:N2_Expressed_Genes
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00036286:Pattern_F
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_6
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(186_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MD_pd(23_min)
[cgc5767]:expression_class_ME
Interaction (46)
WBProcessWBbiopr:00000096
Map_infoMapIVPosition10.8556
PositivePositive_cloneY45F10DInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (16)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene