Y45F10D.4 encodes a putative iron-sulfur cluster assembly enzyme that is required for embryonic and larval viability, and that is orthologous to human NIFUN and budding yeast ISU1 and ISU2; Y45F10D.4 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults; by orthology with yeast ISU1, Y45F10D.4 is predicted to bind FRH-1.
Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in mitochondrial matrix. Expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and pre-eclampsia. Is an ortholog of human ISCU (iron-sulfur cluster assembly enzyme).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.