WormBase Tree Display for Gene: WBGene00009340

WBGene00009340 SMap: S_parent: Sequence: F32G8
  Identity: Version: 2
    Name: CGC_name: best-14 Person_evidence: WBPerson260
      Sequence_name: F32G8.4
      Molecular_name (3)
      Other_name: CELE_F32G8.4 Accession_evidence: NDB BX284605
      Public_name: best-14
    DB_info: Database: AceView gene 5L39
        WormQTL gene WBGene00009340
        WormFlux gene WBGene00009340
        NDB locus_tag CELE_F32G8.4
        Panther gene CAEEL|WormBase=WBGene00009340|UniProtKB=Q19978
          family PTHR10736
        NCBI gene 179471
        RefSeq protein NM_073307.6
        SwissProt UniProtAcc Q19978
        UniProt_GCRP UniProtAcc Q19978
        OMIM gene 607854
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 07 Feb 2012 16:30:56 WBPerson2970 Name_change: CGC_name: best-14
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: best
    Allele (34)
    RNASeq_FPKM (74)
    GO_annotation: 00066569
      00066570
      00066571
      00066572
      00066573
      00117059
    Ortholog (48)
    Paralog (26)
    Structured_description: Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy and retinal degeneration (multiple). Is an ortholog of several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (5)
  Molecular_info: Corresponding_CDS: F32G8.4
    Corresponding_CDS_history: F32G8.4:wp137
    Corresponding_transcript: F32G8.4.1
    Other_sequence (30)
    Associated_feature: WBsf647175
      WBsf1001138
      WBsf232393
  Experimental_info: RNAi_result: WBRNAi00046155 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1014649
      Expr1034085
      Expr1150043
      Expr2009596
      Expr2027833
    Drives_construct: WBCnstr00032271
    Construct_product: WBCnstr00032271
    Microarray_results (20)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_CoreEnriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046858:elt-2(RNAi)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_specific
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:hyp3
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:Hypodermis
      WBPaper00061340:P_cell
      WBPaper00061340:Tail_hypodermis
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:2_0
      WBPaper00065841:30_1
      WBPaper00065841:30_2
      WBPaper00065841:33_0
      WBPaper00065841:33_1
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_3_6
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_F
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00032948:StarveUp2
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      [cgc6390]:Cluster_A
    Interaction: WBInteraction000293785
      WBInteraction000321039
      WBInteraction000443493
      WBInteraction000551616
      WBInteraction000567996
  Map_info: Map: V Position: 2.59073
    Positive: Positive_clone: F32G8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene