WormBase Tree Display for Gene: WBGene00007012

WBGene00007012 Evidence: Author_evidence: Bourbon H-M
  SMap: S_parent: Sequence: ZK546
  Identity: Version: 1
    Name: CGC_name: mdt-4
      Sequence_name: ZK546.13
      Molecular_name: ZK546.13
        ZK546.13.1
        CE34460
      Other_name: CELE_ZK546.13 Accession_evidence: NDB BX284602
      Public_name: mdt-4
    DB_info: Database: AceView gene 2F232
        WormQTL gene WBGene00007012
        WormFlux gene WBGene00007012
        NDB locus_tag CELE_ZK546.13
        Panther gene CAEEL|WormBase=WBGene00007012|UniProtKB=Q23523
          family PTHR13208
        NCBI gene 173852
        RefSeq protein NM_062504.5
        SwissProt UniProtAcc Q23523
        TREEFAM TREEFAM_ID TF332476
        UniProt_GCRP UniProtAcc Q23523
    Species: Caenorhabditis elegans
    History: Version_change: 1 14 May 2004 11:48:16 WBPerson1845 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mdt
    Allele (32)
    RNASeq_FPKM (74)
    GO_annotation: 00078727
      00078728
      00078729
      00078730
      00078731
      00115199
      00115200
      00115201
    Contained_in_operon: CEOP2144
    Ortholog (36)
    Paralog: WBGene00022766
    Structured_description: Automated_description: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex. Human ortholog(s) of this gene implicated in cervical cancer. Is an ortholog of human MED4 (mediator complex subunit 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17903)
  Molecular_info: Corresponding_CDS: ZK546.13
    Corresponding_CDS_history: ZK546.13:wp102
    Corresponding_transcript: ZK546.13.1
    Other_sequence (11)
    Associated_feature: WBsf665497
      WBsf987747
      WBsf222978
  Experimental_info: RNAi_result: WBRNAi00108641 Inferred_automatically: RNAi_primary
      WBRNAi00059503 Inferred_automatically: RNAi_primary
      WBRNAi00009475 Inferred_automatically: RNAi_primary
      WBRNAi00117660 Inferred_automatically: RNAi_primary
      WBRNAi00117662 Inferred_automatically: RNAi_primary
      WBRNAi00117661 Inferred_automatically: RNAi_primary
      WBRNAi00108566 Inferred_automatically: RNAi_primary
      WBRNAi00085236 Inferred_automatically: RNAi_primary
    Expr_pattern (5)
    Drives_construct: WBCnstr00034038
    Construct_product: WBCnstr00034038
    Microarray_results (11)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-4(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:I1_parent
      WBPaper00061340:M1_parent
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062123:GLH-1_interacting
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00063930:BRD-1_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064789:Day6_vs_Day1_upregulated_neuron
      WBPaper00064789:Day9_vs_Day1_upregulated_neuron
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_9
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (64)
  Map_info: Map: II Position: -2.8
    Positive: Positive_clone: ZK546 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006530
    WBPaper00027707
    WBPaper00029038
    WBPaper00038491
    WBPaper00055090
    WBPaper00064789
    WBPaper00065308
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-2.84911)
    [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-2.62093)
  Method: Gene