| WBGene00006730 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F39B2 |
| Identity | Version | 1 |
| | Name | CGC_name | uev-1 | Person_evidence | WBPerson89 |
| | | Sequence_name | F39B2.2 |
| | | Molecular_name | F39B2.2 |
| | | | F39B2.2.1 |
| | | | CE16008 |
| | | Other_name | mms-2 | CGC_data_submission |
| | | | CELE_F39B2.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | uev-1 |
| | DB_info | Database | AceView | gene | 1P383 |
| | | | WormQTL | gene | WBGene00006730 |
| | | | WormFlux | gene | WBGene00006730 |
| | | | NDB | locus_tag | CELE_F39B2.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006730|UniProtKB=O45495 |
| | | | | family | PTHR24068 |
| | | | NCBI | gene | 173347 |
| | | | RefSeq | protein | NM_061177.6 |
| | | | SwissProt | UniProtAcc | O45495 |
| | | | TREEFAM | TREEFAM_ID | TF316971 |
| | | | UniProt_GCRP | UniProtAcc | O45495 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | uev |
| | Allele (20) |
| | Strain | WBStrain00032660 |
| | | WBStrain00037221 |
| | RNASeq_FPKM (74) |
| | GO_annotation (16) |
| | Contained_in_operon | CEOP1764 |
| | Ortholog (42) |
| | Paralog (18) |
| | Structured_description | Concise_description | uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; UEV-1 activity is required cell autonomously for normal trafficking of the GLR-1 glutamate receptor and consequently, for normal locomotory behavior; UEV-1 physically interacts with the UBC-13 ubiquitin conjugating enzyme that is also required for normal locomotory behavior and that is also likely involved in the DNA damage response; a uev-1::gfp reporter fusion is expressed in a wide variety of tissues including the pharynx, neurons, muscle cells, vulva, intestine, distal tip cell, and cells in the anus/tail; UEV-1 reporter fusions localize to nuclei, the cytosol, and ventral cord neurites. | Paper_evidence (3) |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 07 Feb 2011 00:00:00 |
| | | Automated_description | Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of locomotion involved in locomotory behavior and regulation of protein localization to cell surface. Located in cytosol; neuron projection; and nucleus. Expressed in several structures, including anus; distal tip cell; germ line; neurons; and ventral nerve cord. Is an ortholog of human UBE2V2 (ubiquitin conjugating enzyme E2 V2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F39B2.2 |
| | Corresponding_transcript | F39B2.2.1 |
| | Other_sequence (59) |
| | Associated_feature | WBsf643859 |
| | | WBsf657109 |
| | | WBsf986228 |
| | | WBsf218828 |
| Experimental_info | RNAi_result | WBRNAi00116884 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003632 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00046755 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076399 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082831 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr9183 |
| | | Expr9184 |
| | | Expr9707 |
| | | Expr1010234 |
| | | Expr1032806 |
| | | Expr1150629 |
| | | Expr2017742 |
| | | Expr2035881 |
| | Drives_construct | WBCnstr00013774 |
| | Construct_product | WBCnstr00013774 |
| | | WBCnstr00013775 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044128:daf-2(e1370)_downregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:hmc_and_homolog |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:Neuroblast_PVC_LUA |
| | | WBPaper00061340:PVR |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SMB |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061508:P.mirabilis_36h_upregulated |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064750:10mg-nanoplastics_downregulated_protein |
| | | WBPaper00064992:heat-shock_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | cgc4386_cluster_3_4 |
| | | WBPaper00025032:cluster_66 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_E |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (93) |
| Map_info | Map | I | Position | 26.8835 | Error | 0.138356 |
| | Positive | Positive_clone | F39B2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4669 |
| | Pseudo_map_position |
| Reference (16) |
| Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb |
| | Sequence connection from [Boulton S, Vidal M] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
