WormBase Tree Display for Gene: WBGene00006454

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WBGene00006454	SMap	S_parent	Sequence	T14G12
	Identity	Version	3
		Name	CGC_name	aex-4	Person_evidence	WBPerson655
			Sequence_name	T14G12.2
			Molecular_name	T14G12.2
				T14G12.2.1
				CE35769
			Other_name	tag-81	Person_evidence	WBPerson201
				CELE_T14G12.2	Accession_evidence	NDB	BX284606
			Public_name	aex-4
		DB_info	Database	AceView	gene	XE349
				WormQTL	gene	WBGene00006454
				WormFlux	gene	WBGene00006454
				NDB	locus_tag	CELE_T14G12.2
				Panther	gene	CAEEL\|WormBase=WBGene00006454\|UniProtKB=G5EEN8
					family	PTHR19305
				NCBI	gene	188509
				RefSeq	protein	NM_076240.8
				SwissProt	UniProtAcc	G5EEN8
				TREEFAM	TREEFAM_ID	TF315125
				UniProt_GCRP	UniProtAcc	G5EEN8
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:40	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	05 Oct 2005 15:36:35	WBPerson2970	Event	Acquires_merge	WBGene00020513
							Name_change	Sequence_name	T14G12.2
				3	20 Oct 2008 11:43:53	WBPerson2970	Event	Acquires_merge	WBGene00000087
							Name_change	CGC_name	aex-4
			Acquires_merge	WBGene00000087
				WBGene00020513
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	aex
		Allele (31)
		Legacy_information	[Jim Thomas] Defecation defective, moderately constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in about 6 of 7 defecation cycles, adult males unaffected and mate well.
			See also sa22
			[C.elegansII] sa22 : defecation defective, moderately constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) missing in about 6 of 7 defecation cycles, adult males unaffected and mate well. [Thomas 1990; JT]
		Strain (4)
		RNASeq_FPKM (74)
		GO_annotation (15)
		Ortholog (28)
		Paralog	WBGene00004364	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00019305	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Automated_description	Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in positive regulation of defecation and positive regulation of protein secretion. Located in plasma membrane.	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	T14G12.2
		Corresponding_transcript	T14G12.2.1
		Other_sequence	MPC00142_1
			CN477730.1
			MP00331
			CN477779.1
			MP00411
		Associated_feature	WBsf647962
			WBsf647963
			WBsf647964
			WBsf647965
			WBsf235519
	Experimental_info	RNAi_result	WBRNAi00053340	Inferred_automatically	RNAi_primary
			WBRNAi00035577	Inferred_automatically	RNAi_primary
			WBRNAi00089980	Inferred_automatically	RNAi_primary
			WBRNAi00107620	Inferred_automatically	RNAi_primary
			WBRNAi00114418	Inferred_automatically	RNAi_primary
			WBRNAi00090298	Inferred_automatically	RNAi_primary
			WBRNAi00089873	Inferred_automatically	RNAi_primary
			WBRNAi00090139	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr8376
			Expr8377
			Expr1015578
			Expr1156926
			Expr2009249
			Expr2027486
		Drives_construct	WBCnstr00005427
			WBCnstr00005428
			WBCnstr00037903
		Construct_product	WBCnstr00005428
			WBCnstr00037903
		Microarray_results (18)
		Expression_cluster	WBPaper00037055:DAF-16_binding_DNA
			WBPaper00037950:coelomocytes_L2-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038168:lin-15B(n744)_upregulated
			WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
			WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
			WBPaper00044736:flat_dev_expression
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00049018:swsn-2.2(RNAi)_upregulated
			WBPaper00049217:TCER-1_upregulated
			WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
			WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
			WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00051039:intestine_enriched
			WBPaper00052884:emb-4(hc60)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053302:stavudine_24h_regulated
			WBPaper00053388:dauer_regulated_Cluster1
			WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
			WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
			WBPaper00053810:daf-2(e1370)_upregulated
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00055354:eat-2(ad1116)_downregulated
			WBPaper00055354:Psora-Allantoin_downregulated
			WBPaper00055354:Psora_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Metformin_downregulated
			WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00056809:smn-1(ok355)_upregulated
			WBPaper00056826:hmc_biased
			WBPaper00058711:paraquat_downregulated
			WBPaper00058725:sftb-1(cer6)_upregulated
			WBPaper00058948:PA14_downregulated
			WBPaper00059191:hsp-16.2p-LIN-29_downregulated
			WBPaper00059763:neuron_acr-2(n2420gf)_regulated
			WBPaper00060014:set-2(zr2012)_downregulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
			WBPaper00060661:sensory-neuron_enriched
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061357:mett-10(ok2204)_downregulated_OP50
			WBPaper00061405:S.aureus_upregulated_starvation
			WBPaper00061439:unc-30(ok613)_downregulated
			WBPaper00061527:F58F9.3_11574-R07B7.6
			WBPaper00061823:mex-3(spr9)_downregulated
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064632:daf-2(e1370)_upregulated_intestine
			WBPaper00064716:paraquat_downregulated
			WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
			WBPaper00065258:anchor-cell_depleted
			WBPaper00065581:hpk-1(pk1393)_downregulated
			WBPaper00065734:unc-25(e156)_upregulated
			WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
			WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
			WBPaper00065841:3_5
			WBPaper00065841:39_2
			WBPaper00065841:85_0
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066110:Cisplatin_upregulated_tetraploid
			WBPaper00066232:ash-2(RNAi)_downregulated_WT
			WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
			cgc4489_group_22
			WBPaper00026980:intestine_enriched
			WBPaper00036286:Pattern_D
			WBPaper00038172:tax-6null_up_regulated
			WBPaper00038231:Cry5B_1.5-fold_upregulated
			WBPaper00045673:colistin_upregulated
			WBPaper00045960:L4-lethargus_upregulated
			WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00048989:N2_rapamycin_upregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00055435:MUA-AuNP-0.5_upregulated
			WBPaper00055899:nitroguanidine_regulated
		Interaction	WBInteraction000321103
			WBInteraction000524187
			WBInteraction000542400
		WBProcess	WBbiopr:00000010
	Map_info	Map	X	Position	-9.67526	Error	0.015501
		Positive	Positive_clone	T14G12	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5649
				1550
				1551
				1588
				2291
		Pseudo_map_position
	Reference (13)
	Remark	Gene name created from parsing 'genotype' field from CGC strain information	CGC_data_submission
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene