| WBGene00006368 | SMap | S_parent | Sequence | C54H2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | sym-3 | Person_evidence | WBPerson252 |
| | | Sequence_name | C54H2.1 |
| | | Molecular_name | C54H2.1a |
| | | | C54H2.1a.1 |
| | | | CE38303 |
| | | | C54H2.1b |
| | | | CE38304 |
| | | | C54H2.1a.2 |
| | | | C54H2.1b.1 |
| | | | C54H2.1b.2 |
| | | Other_name | CELE_C54H2.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | sym-3 |
| | DB_info | Database | WormQTL | gene | WBGene00006368 |
| | | | WormFlux | gene | WBGene00006368 |
| | | | NDB | locus_tag | CELE_C54H2.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006368|UniProtKB=Q86GI2 |
| | | | | family | PTHR21456 |
| | | | NCBI | gene | 183819 |
| | | | RefSeq | protein | NM_001029329.8 |
| | | | | | NM_001029330.3 |
| | | | TREEFAM | TREEFAM_ID | TF320966 |
| | | | TrEMBL | UniProtAcc | Q86GI2 |
| | | | | | G5EE38 |
| | | | UniProt_GCRP | UniProtAcc | Q86GI2 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sym |
| | Allele (67) |
| | Legacy_information | [Herman RK] sym-3(mn618) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation |
| | Strain | WBStrain00034405 |
| | | WBStrain00034416 |
| | RNASeq_FPKM (74) |
| | Ortholog (40) |
| | Structured_description | Concise_description | sym-3 encodes, by alternative splicing, two isoforms of a protein withno recognizably conserved domains, but with orthology to human FAM102A (EEIG1; OMIM:610891) and FAM102B, and to Drosophila CG8671; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. | Paper_evidence | WBPaper00003663 |
| | | | | | WBPaper00024639 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 04 May 2006 00:00:00 |
| | | Automated_description | Enriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and head neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and eat-2 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including Lithium Chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: NT-type C2 domain; EEIG1/2-like; and N-terminal C2 in EEIG1 and EHBP1 proteins. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C54H2.1a |
| | | C54H2.1b |
| | Corresponding_CDS_history | C54H2.1:wp107 |
| | | C54H2.1:wp141 |
| | Corresponding_transcript | C54H2.1a.1 |
| | | C54H2.1a.2 |
| | | C54H2.1b.1 |
| | | C54H2.1b.2 |
| | Other_sequence (21) |
| | Associated_feature | WBsf1005379 |
| | | WBsf1005380 |
| | | WBsf1023007 |
| Experimental_info | RNAi_result | WBRNAi00043193 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030166 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062556 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062555 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1020038 |
| | | Expr1032567 |
| | | Expr1147171 |
| | | Expr2017181 |
| | | Expr2035317 |
| | Drives_construct | WBCnstr00034386 |
| | Construct_product | WBCnstr00016047 |
| | | WBCnstr00034386 |
| | Microarray_results (27) |
| | Expression_cluster | WBPaper00031132:LiCl_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:daf-16(mu86)_downregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055354:Allantoin_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056290:mdt-15(mg584)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061340:ASK |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065841:10_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_2 |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (6) |
| Map_info | Map | X | Position | -4.37222 | Error | 0.007269 |
| | Positive | Positive_clone | C54H2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 7092 |
| | | | 7093 |
| Reference (16) |
| Method | Gene |
