| WBGene00004405 | SMap | S_parent | Sequence | CHROMOSOME_V |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | rop-1 |
| | | Sequence_name | C12D8.11 |
| | | Molecular_name | C12D8.11 |
| | | | C12D8.11.1 |
| | | | CE15613 |
| | | Other_name | rop1 | Accession_evidence | EMBL | U21487 |
| | | | Ro | Paper_evidence | WBPaper00002296 |
| | | | CELE_C12D8.11 | Accession_evidence | NDB | BX284605 |
| | | Public_name | rop-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rop |
| | Allele (42) |
| | Legacy_information | [C.elegansII] NMK. Encodes predicted 643 aa protein, 36% identity to human and Xenopus Ro proteins. Antibody detects 69 kD protein, which coprecipitates with and binds to small Y RNA encoded by yrn-1. [Van Horn et al. 1995; Labbe et al. 1995; LR] |
| | Strain | WBStrain00026659 |
| | | WBStrain00032716 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00079480 |
| | | 00079481 |
| | | 00079482 |
| | | 00079483 |
| | | 00079484 |
| | | 00079485 |
| | | 00079486 |
| | | 00112786 |
| | Ortholog (51) |
| | Structured_description | Concise_description | rop-1 encodes an RNAi-binding protein that is orthologous to the vertebrate 60-kDa Ro autoantigen that is the protein component of the Ro ribonucleoprotein (RNP) complex; ROP-1 binds the single C. elegans Ro RNP RNA component, YRN-1 (Y RNA) in vivo and although loss of rop-1 activity via mutation results in no obvious visible phenotypes, it does result in a dramatic decrease in YRN-1 levels, indicating that ROP-1 is necessary for maintaining normal levels of the Ro RNP Y RNA; in addition, rop-1 mutations also result in a statistically significant increase in mutant 5S rRNA molecules found in ribosomal RNA preparations, suggesting that ROP-1 may play a role in quality control of 5S rRNA processing; rop-1 mRNA is detectable during all stages of development, and rop-1 promoter fusions appear to be expressed in all cell types, except the germline. | Paper_evidence | WBPaper00002296 |
| | | | | | WBPaper00002372 |
| | | | | | WBPaper00003364 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 14 Aug 2006 00:00:00 |
| | | Automated_description | Predicted to enable RNA binding activity. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Expressed in several structures, including intestine and neurons. Is an ortholog of human RO60 (Ro60, Y RNA binding protein). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info (4) |
| Experimental_info | RNAi_result | WBRNAi00067083 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00066953 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067243 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00002288 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027804 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040391 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067081 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00010652 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1298 |
| | | Expr1299 |
| | | Expr7434 |
| | | Expr1016369 |
| | | Expr1032212 |
| | | Expr1144453 |
| | | Expr2015412 |
| | | Expr2033647 |
| | Drives_construct | WBCnstr00000280 |
| | | WBCnstr00001907 |
| | | WBCnstr00012577 |
| | | WBCnstr00035508 |
| | Construct_product | WBCnstr00001907 |
| | | WBCnstr00035508 |
| | Antibody | WBAntibody00001791 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00027057:DCR-1_interacting_embryo |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_12h |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040990:PA14_upregulated |
| | | WBPaper00042034:NO_upregulated_hsf-1(sy441) |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00050448:KGB-1-induced |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00054189:P.aeruginosa_regulated_protein |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059254:CSR-1_interacting |
| | | WBPaper00059254:PRG-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059537:ngn-1(ok2200)_upregulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060434:pH4.33_vs_pH6.33_uprgulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_upregulated |
| | | WBPaper00061527:lst-4_22151-F46F11.6_12556 |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:RIS_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062184:PA14_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064055:trl-1(cas1078)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064750:1mg-nanoplastics_downregulated_protein |
| | | WBPaper00064750:10mg-nanoplastics_downregulated_protein |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065746:tmc-1(rg1003)_downregulated |
| | | WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2 |
| | | WBPaper00065841:13_0 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065945:global-rpoa-2(-)_upregulated_transcript |
| | | cgc4489_group_3 |
| | | WBPaper00025032:cluster_66 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031060:2-deoxy-D-glucose_upregulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035429:UVC_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00044013:nasp-1_downregulated |
| | | WBPaper00044091:Bpseudomallei_induced_2h |
| | | WBPaper00044091:Bpseudomallei_induced_4h |
| | | WBPaper00044091:Bpseudomallei_induced_8h |
| | | WBPaper00044091:Bpseudomallei_induced_12h |
| | | WBPaper00044535:male_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated |
| | | [cgc5767]:cluster_20 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(41_min) |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (62) |
| Map_info | Map | V | Position | 2.43009 | Error | 0.002437 |
| | Positive | Positive_clone | C12D8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (21) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
