| WBGene00004078 | SMap | S_parent | Sequence | F52E1 |
|---|
| Identity | Version | 1 |
| | Name (5) |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pos |
| | Allele (25) |
| | Legacy_information | [Tabara H] Terminal stage pos-1 mutant embryos lack germ cell progenitors and intestine. ABp also produces pharynx. Maternal mRNA of pos-1 localizes into P-lineage. |
| | Strain | WBStrain00022471 |
| | | WBStrain00005744 |
| | | WBStrain00030276 |
| | | WBStrain00022478 |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (47) |
| | Paralog (20) |
| | Structured_description | Concise_description | pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; POS-1 can also bind the mex-6 3'-UTR in vitro, although expression of a MEX-6 reporter fusion protein does not appear to be affected in pos-1 mutant animals; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules. | Paper_evidence | WBPaper00003382 |
| | | | | | WBPaper00005822 |
| | | | | | WBPaper00028569 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 09 Feb 2012 00:00:00 |
| | | Automated_description | Enables mRNA 3'-UTR binding activity; poly(U) RNA binding activity; and transcription corepressor activity. Involved in several processes, including cell fate specification; embryonic pattern specification; and negative regulation of transcription by RNA polymerase II. Located in P granule. Expressed in several structures, including Psub4; germ line; neurons; oocyte; and rectal gland cell. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12862) |
| | | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1108) |
| Molecular_info | Corresponding_CDS | F52E1.1 |
| | Corresponding_transcript | F52E1.1.1 |
| | Other_sequence (43) |
| | Associated_feature | WBsf977478 |
| | | WBsf977479 |
| | | WBsf977480 |
| | | WBsf978729 |
| | | WBsf232104 |
| | | WBsf232105 |
| | Gene_product_binds | WBsf028078 |
| | | WBsf034245 |
| | Transcription_factor | WBTranscriptionFactor000111 |
| Experimental_info | RNAi_result (46) |
| | Expr_pattern (14) |
| | Drives_construct | WBCnstr00012723 |
| | | WBCnstr00017949 |
| | | WBCnstr00040853 |
| | | WBCnstr00042916 |
| | Construct_product | WBCnstr00000085 |
| | | WBCnstr00005587 |
| | | WBCnstr00016851 |
| | | WBCnstr00017949 |
| | | WBCnstr00021253 |
| | | WBCnstr00022630 |
| | Antibody | WBAntibody00000207 |
| | | WBAntibody00000208 |
| | | WBAntibody00000425 |
| | | WBAntibody00001053 |
| | | WBAntibody00001403 |
| | | WBAntibody00001621 |
| | | WBAntibody00001637 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032097:CGH-1-associated-mRNA |
| | | WBPaper00036738:4uM_Heme_upregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045050:drh-3 (ne4253)_downregulated |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045420:fertilization_upregulated_protein |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045618:fbf-1_downregulated |
| | | WBPaper00045618:puf-8_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053154:human-amyloid-beta_tau_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00054191:H3.3(null)_L1_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00054792:FOG-3_interacting |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:atfs-1(et15)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L4 |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_downregulated |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059728:5ug_cholesterol_downregulated |
| | | WBPaper00059728:20ug_cholesterol_downregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L4 |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L1 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00060909:atfs-1(et18)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061045:Y56A3A.22(cck200)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:Germline |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:T22D1.5-inx-14 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_upregulated |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062118:neural-HSF-1_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062197:mec-8_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00062446:nhr-8(hd117)_downregulated |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062672:let-418(n3536)dcp-66(RNAi)_downregulated |
| | | WBPaper00062672:let-418(n3536)_downregulated |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064080:let-7_miRNA_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_PGCs |
| | | WBPaper00064494:postdauer_downregulated_WholeAnimal |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064602:egl-9(sa307)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065074:glna(-)_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065132:asna-1(ok938)_downregulated_protein |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065288:mdt-15(tm2182)_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065623:18 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_4_1 |
| | | cgc4489_group_9 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00025032:cluster_1 |
| | | WBPaper00025032:cluster_131 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027758:Regulated_genes_not_in_group |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031703:heme_responsive_2 |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_3 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037695:DD_3-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038172:aak-2overexpression_up_regulated |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00044535:male_upregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00051387:Triclosan_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00053550:daf-19(m86)_upregulated_L1 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(41_min) |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (331) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | V | Position | 1.40307 | Error | 0.003599 |
| | Positive | Positive_clone | F52E1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4596 |
| | Pseudo_map_position |
| Reference (132) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
