| WBGene00004063 | SMap | S_parent | Sequence | CHROMOSOME_I |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | pmr-1 |
| | | Sequence_name | ZK256.1 |
| | | Molecular_name (11) |
| | | Other_name | pmr1 | Accession_evidence | EMBL | AJ303081 |
| | | | | | | AJ303082 |
| | | | CELE_ZK256.1 | Accession_evidence | NDB | BX284601 |
| | | Public_name | pmr-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pmr |
| | Allele (285) |
| | RNASeq_FPKM (74) |
| | GO_annotation (35) |
| | Contained_in_operon | CEOP1682 |
| | Ortholog (42) |
| | Paralog (14) |
| | Structured_description | Concise_description | The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). | Paper_evidence | WBPaper00004659 |
| | | | | Curator_confirmed | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables P-type calcium transporter activity and P-type manganese transporter activity. Involved in several processes, including metal ion transport; response to metal ion; and response to oxidative stress. Located in Golgi apparatus and membrane. Expressed in male gonad; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Is an ortholog of human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0050429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13211) |
| | Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpression of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 29 May 2013 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK256.1a |
| | | ZK256.1b |
| | | ZK256.1c |
| | Corresponding_CDS_history | ZK256.1:wp114 |
| | | ZK256.1a:wp49 |
| | | ZK256.1b:wp77 |
| | Corresponding_transcript (5) |
| | Other_sequence (75) |
| | Associated_feature (13) |
| Experimental_info | RNAi_result | WBRNAi00059919 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00038238 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116858 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059917 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059303 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059920 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086175 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059921 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram1105 |
| | | Expr3187 |
| | | Expr7200 |
| | | Expr1017781 |
| | | Expr1031961 |
| | | Expr1162731 |
| | | Expr2014977 |
| | | Expr2033212 |
| | Drives_construct | WBCnstr00003233 |
| | | WBCnstr00011207 |
| | Construct_product | WBCnstr00011207 |
| | Antibody | WBAntibody00000363 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_protein |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:RIB |
| | | WBPaper00061527:lpd-3-F54B3.1_21769 |
| | | WBPaper00061527:npp-8_4368-E01B7.1_7741 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:58_0 |
| | | WBPaper00065841:59_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:122_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_6 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (69) |
| Map_info | Map | I | Position | 17.0977 | Error | 0.064933 |
| | Positive | Positive_clone | ZK256 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5071 |
| | Pseudo_map_position |
| Reference (22) |
| Remark | Sequence connection from [Van Baelenk, Wuytack, F] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
