| WBGene00004020 | SMap | S_parent | Sequence | EGAP2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | pho-1 | Person_evidence | WBPerson411 |
| | | Sequence_name | EGAP2.3 |
| | | Molecular_name | EGAP2.3 |
| | | | EGAP2.3.1 |
| | | | CE04325 |
| | | Other_name | CELE_EGAP2.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | pho-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pho |
| | Allele (44) |
| | Legacy_information | [C.elegansII] ca101 : electrophoretic variant in major acidphosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein,55kD subunit; activity detected at luminal edge of most gut cells, but not 6 most anterior. [Beh et al. 1991; JM] |
| | | [Beh CT, McGhee JD] ca101 leads to electrophoretic variant in major acid phosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein, 55kD subunit, activity detected at luminal edge of most gut cells, but not 6 most anterior. |
| | Strain | WBStrain00022680 |
| | | WBStrain00022679 |
| | | WBStrain00022681 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00063393 |
| | | 00063394 |
| | | 00063395 |
| | | 00063396 |
| | | 00063397 |
| | | 00063398 |
| | | 00063399 |
| | | 00063400 |
| | Ortholog (27) |
| | Paralog (23) |
| | Structured_description | Concise_description | pho-1 encodes the major C. elegans intestinal acid phosphatase; PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. | Paper_evidence | WBPaper00001454 |
| | | | | | WBPaper00005295 |
| | | | | | WBPaper00017091 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 27 Mar 2014 00:00:00 |
| | | Automated_description | Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Located in membrane raft. Expressed in intestine. Used to study obesity. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 28 Jun 2022 00:00:00 |
| Models_disease_in_annotation | WBDOannot00001252 |
| Molecular_info | Corresponding_CDS | EGAP2.3 |
| | Corresponding_transcript | EGAP2.3.1 |
| | Other_sequence (29) |
| | Associated_feature | WBsf650050 |
| | | WBsf650051 |
| | | WBsf665523 |
| | | WBsf982352 |
| | | WBsf982353 |
| | | WBsf223018 |
| | | WBsf223019 |
| | | WBsf223020 |
| | | WBsf223021 |
| Experimental_info | RNAi_result (18) |
| | Expr_pattern (6) |
| | Drives_construct | WBCnstr00000345 |
| | | WBCnstr00035738 |
| | Construct_product | WBCnstr00035738 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00027339:daf-12(rh273)_downregulated |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00037777:lipid_raft_proteins |
| | | WBPaper00037950:intestine_CoreEnriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:intestine_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040412:germline-regulated_daf-12_target |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00044005:DAF-16_downregulated |
| | | WBPaper00044557:DietaryRestriction_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_upregulated |
| | | WBPaper00045390:ubc-9(RNAi)_upregulated |
| | | WBPaper00045401:N.parisii_40h_downregulated |
| | | WBPaper00045401:N.parisii_64h_downregulated |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048810:CoQ-deficiency_downregulated |
| | | WBPaper00048952:glucose_induced |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049325:CB4856_vs_N2_DEG |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00049954:BPA_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050332:daf-16(RNAi)_downregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050561:indole_10-fold_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00051305:vit-2(ac3)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053094:adr-2(ok735)_neuron_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053318:mir-71(n4115)_downregulated_mRNA |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00054872:egl-9(sa307)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055137:S.maltophilia_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056218:daf-16(mu86)_downregulated_Day5 |
| | | WBPaper00056218:daf-16(mu86)_downregulated_Day7 |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056586:kri-1(ok1251)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_downregulated |
| | | WBPaper00057254:MWCNT_downregulated_mRNA |
| | | WBPaper00057265:metaformin_upregulated_OP50 |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057347:nhr-14(tm1473)_upreglated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059253:sucrose_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059604:fluvastatin_upregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_upregulated_N2 |
| | | WBPaper00059839:S.maltophilia_regulated |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061040:FW1256_upregulated |
| | | WBPaper00061106:endu-2(tm4977)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061405:S.aureus_upregulated_starvation |
| | | WBPaper00061527:gst-26-pho-1_10767 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061823:mex-3(spr9)_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00062440:crh-1(syb385)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00062684:pathogen_upregulated_CB4856 |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064602:egl-9(sa307)_downregulated |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00064952:Day10_vs_Day1_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_25C |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:JU1400_N.ironsii_regulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065199:Transgeneration-starvation_regulated_starved |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065392:P.pentosaceus_upregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:3_1 |
| | | WBPaper00065841:3_2 |
| | | WBPaper00065945:global-rpoa-2(-)_downregulated_transcript |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4386_cluster_2_3 |
| | | cgc4489_group_3 |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025032:cluster_108 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00028789:PA14_vs_gacA_downregulated_4hr |
| | | WBPaper00028789:PA14_vs_OP50_downregulated_4hr |
| | | WBPaper00028789:PA14_vs_OP50_downregulated_8hr |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037113:DZN_16C_down-regulated |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038231:Cry5B_2-fold_downregulated |
| | | WBPaper00039851:HK_C_albicans_vs_HK_OP50 |
| | | WBPaper00039851:Live_C_albicans_vs_HK_OP50 |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2down |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041211:RPW-24_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00045374:Benzene_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047021:MWCNT_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053688:E.faecalis_downregulated |
| | | WBPaper00053688:E.faecium_downregulated |
| | | WBPaper00055435:MUA-AuNP-0.5_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:Cluster_C |
| | Interaction (67) |
| Map_info | Map | II | Position | -1.84291 | Error | 0.018889 |
| | Positive | Positive_clone | EGAP2 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 7072 |
| | | | 7073 |
| | | | 7074 |
| | | Multi_point | 3635 |
| | | | 3636 |
| | | | 5004 |
| | | | 5035 |
| Reference (19) |
| Remark | Data extracted from Beh et al. (1991) |
| | Sequence connection from [McGhee JD] |
| Method | Gene |
