| WBGene00004010 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | pha-1 | Person_evidence | WBPerson561 |
| | | Sequence_name | Y48A6C.5 |
| | | Molecular_name | Y48A6C.5a |
| | | | Y48A6C.5a.1 |
| | | | CE22115 |
| | | | Y48A6C.5b |
| | | | CE34124 |
| | | | Y48A6C.5b.1 |
| | | Other_name | pha1 | Accession_evidence | EMBL | X73845 |
| | | | CELE_Y48A6C.5 | Accession_evidence | NDB | BX284603 |
| | | Public_name | pha-1 |
| | DB_info | Database | AceView | gene | 3M225 |
| | | | WormQTL | gene | WBGene00004010 |
| | | | WormFlux | gene | WBGene00004010 |
| | | | NDB | locus_tag | CELE_Y48A6C.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004010|UniProtKB=G5EGL5 |
| | | | | family | PTHR11929 |
| | | | NCBI | gene | 176543 |
| | | | RefSeq | protein | NM_001027720.3 |
| | | | | | NM_001027719.5 |
| | | | TREEFAM | TREEFAM_ID | TF322298 |
| | | | TrEMBL | UniProtAcc | G5EGL5 |
| | | | | | Q7YXC4 |
| | | | UniProt_GCRP | UniProtAcc | G5EGL5 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pha |
| | Allele (70) |
| | Legacy_information | See also e2123, e2275, e2286, e2468 |
| | | [C.elegansII] e2123ts : at 25C zygotic embryonic lethal, pharynx fails to undergo late differentiation and morphogenesis; early pharynx development normal. OA>5: e2468 (unconditional), t1001ts,e2286 (weak, 38% hatch and arrest), t1002 (weak,some survival to late larval arrest), etc.See also extragenic suppressors sup-35, sup-36, sup-37. Cloned: 2.2kb embryonic transcript, encodes 491 aa predicted protein with some similarity to bZIP transcription factors; pha-1:lacZ expressed transiently in all pharyngeal precursor cells. [Granato et al. 1994; GE] |
| | Strain (593) |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (20) |
| | Paralog (14) |
| | Structured_description | Concise_description | pha-1 encodes a novel protein that contains a DUF1114 domain of unknown function found in a number of other nematode proteins; during embryonic development, pha-1 functions redundantly with class B SynMuv genes such as lin-35/Rb and efl-1 to effect pharyngeal morphogenesis; in regulating pharyngeal development, PHA-1 also appears to act with the UBC-18 ubiquitin conjugating enzyme; a PHA-1::GFP reporter is broadly expressed during embryonic development and localizes to the cytoplasm; expression is also observed in early- and late-larval-stage animals, as well as adults, although postembryonic expression is generally weaker than that seen in the embryo. | Paper_evidence | WBPaper00001348 |
| | | | | | WBPaper00002047 |
| | | | | | WBPaper00024215 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Jul 2007 00:00:00 |
| | | Automated_description | Predicted to enable alpha-(1->3)-fucosyltransferase activity. Involved in embryonic digestive tract morphogenesis; nematode larval development; and reproduction. Located in cytoplasm. Expressed in body wall muscle cell and pharynx. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y48A6C.5a |
| | | Y48A6C.5b |
| | Corresponding_transcript | Y48A6C.5a.1 |
| | | Y48A6C.5b.1 |
| | Other_sequence | X73845 |
| | Associated_feature | WBsf994278 |
| | | WBsf994279 |
| | | WBsf1015931 |
| | | WBsf1015932 |
| | | WBsf225796 |
| | | WBsf225797 |
| | Transcription_factor | WBTranscriptionFactor000527 |
| Experimental_info | RNAi_result (34) |
| | Expr_pattern | Expr1579 |
| | | Expr2985 |
| | | Expr1025653 |
| | | Expr1031918 |
| | | Expr1160324 |
| | | Expr2014879 |
| | | Expr2033114 |
| | Drives_construct | WBCnstr00000210 |
| | | WBCnstr00000211 |
| | | WBCnstr00000212 |
| | | WBCnstr00010343 |
| | | WBCnstr00011064 |
| | | WBCnstr00014859 |
| | | WBCnstr00018920 |
| | | WBCnstr00019419 |
| | | WBCnstr00022365 |
| | Construct_product (13) |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:5_0 |
| | | WBPaper00065841:5_1 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00040876:mir-35_upregulated |
| | Interaction (57) |
| Map_info | Map | III | Position | 6.14398 | Error | 0.074527 |
| | Well_ordered |
| | Positive | Inside_rearr | tDf1 |
| | | | tDp1 |
| | | | tDp2 |
| | | Positive_clone | CB#H8J04 |
| | | | Y48A6C | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point (4) |
| | | Pos_neg_data | 5729 |
| | | | 5738 |
| | | | 5949 |
| | | | 8415 |
| Reference (95) |
| Method | Gene |
