| WBGene00003829 | SMap | S_parent | Sequence | F53A2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | nud-1 | Person_evidence | WBPerson87 |
| | | Sequence_name | F53A2.4 |
| | | Molecular_name | F53A2.4 |
| | | | F53A2.4.1 |
| | | | CE16096 |
| | | Other_name | CELE_F53A2.4 | Accession_evidence | NDB | BX284603 |
| | | Public_name | nud-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nud |
| | Allele (18) |
| | Strain | WBStrain00035169 |
| | | WBStrain00031486 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Contained_in_operon | CEOP3784 |
| | Ortholog (36) |
| | Structured_description | Concise_description | nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. | Paper_evidence | WBPaper00004895 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables identical protein binding activity and unfolded protein binding activity. Involved in several processes, including GABAergic synaptic transmission; chaperone-mediated protein folding; and establishment of organelle localization. Predicted to be located in cytoplasm. Expressed in gonad; hypodermis; intestine; and neurons. Used to study epilepsy and lissencephaly. Is an ortholog of human NUDC (nuclear distribution C, dynein complex regulator). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Aug 2021 00:00:00 |
| | | DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 |
| | | | | Accession_evidence | OMIM | 607432 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 17 Apr 2013 00:00:00 |
| | Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; worms depleted for LIS1 pathway components via RNA interference (NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1) also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Paper_evidence | WBPaper00024523 |
| | | | | | WBPaper00028525 |
| | | | | Accession_evidence | OMIM | 601545 |
| | | | | Curator_confirmed | WBPerson324 |
| Models_disease_in_annotation | WBDOannot00000148 |
| | WBDOannot00001010 |
| Molecular_info (4) |
| Experimental_info | RNAi_result (22) |
| | Expr_pattern | Expr2419 |
| | | Expr10134 |
| | | Expr1011738 |
| | | Expr1031804 |
| | | Expr1151858 |
| | | Expr2014524 |
| | | Expr2032763 |
| | Drives_construct | WBCnstr00000117 |
| | Construct_product | WBCnstr00007338 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_12h |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045316:prg-1_downregulated_L1 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:F31C3.4_6048-cutc-1_15804 |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062123:DEPS-1_interacting |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064315:mes-3(bn199)_downregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F2 |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | cgc4489_group_4 |
| | | cgc4489_hermaphrodite_enriched_transcription_factors |
| | | WBPaper00025032:cluster_105 |
| | | WBPaper00025032:PAL-1_target_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00027758:Group_IV |
| | | WBPaper00032165:A_to_C_transit_decreased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_7 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_6 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MDE |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (45) |
| Map_info | Map | III | Position | 21.2108 | Error | 0.000119 |
| | Positive | Positive_clone | F53A2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4503 |
| | | | 4549 |
| | Pseudo_map_position |
| Reference (23) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
