WormBase Tree Display for Gene: WBGene00003785

WBGene00003785 SMap: S_parent: Sequence: Y53C12B
  Identity: Version: 1
    Name: CGC_name: nos-3 Person_evidence: WBPerson575
      Sequence_name: Y53C12B.3
      Molecular_name (15)
      Other_name: syt-1
        pqn-86
        Nanos Paper_evidence: WBPaper00053101
        CELE_Y53C12B.3 Accession_evidence: NDB BX284602
      Public_name: nos-3
    DB_info: Database: AceView gene 2K39
        WormQTL gene WBGene00003785
        WormFlux gene WBGene00003785
        NDB locus_tag CELE_Y53C12B.3
        NCBI gene 174535
        RefSeq protein NM_001393164.1
            NM_001393165.1
            NM_063700.4
            NM_001395805.1
            NM_063701.5
        TREEFAM TREEFAM_ID TF350042
        TrEMBL UniProtAcc A0A7R9XN27
            O62486
            O18218
            A0A7R9XLP7
            A0A7R9XMZ3
        UniProt_GCRP UniProtAcc A0A7R9XMZ3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nos
    Allele (82)
    Strain: WBStrain00022580
      WBStrain00022615
      WBStrain00054810
    RNASeq_FPKM (74)
    GO_annotation: 00031725
      00031726
      00031727
      00031728
      00031729
      00031730
      00031731
      00037989
    Ortholog (20)
    Structured_description: Concise_description: nos-3 encodes a homolog of Drosophila NANOS that physically interacts with FBF-1 (similar, though not orthologous, to Drosophila PUMILIO); NOS-3 is required in development of the hermaphrodite germ-line to promote the switch from sperm to oocyte production, perhaps by forming a complex with FBF-1 that controls fem-3 mRNA. Paper_evidence: WBPaper00003692
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Involved in positive regulation of meiotic nuclear division. Located in cytoplasm. Expressed in several structures, including Psub3; Psub4; Z2; Z3; and germ line. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y53C12B.3a
      Y53C12B.3b
      Y53C12B.3c
      Y53C12B.3d
      Y53C12B.3e
    Corresponding_transcript (5)
    Other_sequence: CR00137
      CRC05300_1
      CR00136
      MC05328
      CR08429
    Associated_feature (11)
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr1202
      Expr1203
      Expr1011795
      Expr1031771
      Expr1160694
      Expr2014358
      Expr2032599
    Drives_construct: WBCnstr00008698
      WBCnstr00008699
      WBCnstr00008700
      WBCnstr00035868
    Construct_product: WBCnstr00005242
      WBCnstr00008698
      WBCnstr00008699
      WBCnstr00008700
      WBCnstr00035868
    Antibody: WBAntibody00000240
    Microarray_results (42)
    Expression_cluster: WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033070:Rhine_upregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057254:MWCNT_downregulated_mRNA
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060871:M.humicola-extract_12h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061340:RMED
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_9
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_F
      [cgc6390]:intrinsic
    Interaction (122)
  Map_info: Map: II Position: 1.70862 Error: 0.00125
    Positive: Positive_clone: Y53C12B Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4543
        5522
    Pseudo_map_position
  Reference (65)
  Picture: WBPicture0000013095
  Remark: Sequence connection from [Kraemer B, Kimble JE, Wickens MP]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene