WormBase Tree Display for Gene: WBGene00003421

WBGene00003421 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F09E8
  Identity: Version: 1
    Name: CGC_name: msh-5 Person_evidence: WBPerson1547
      Sequence_name: F09E8.3
      Molecular_name: F09E8.3a
        F09E8.3a.1
        CE26678
        F09E8.3b
        CE49987
        F09E8.3b.1
      Other_name: CELE_F09E8.3 Accession_evidence: NDB BX284604
      Public_name: msh-5
    DB_info: Database: AceView gene 4N927
        WormQTL gene WBGene00003421
        WormFlux gene WBGene00003421
        NDB locus_tag CELE_F09E8.3
        Panther gene CAEEL|WormBase=WBGene00003421|UniProtKB=Q19272
          family PTHR11361
        NCBI gene 178268
        RefSeq protein NM_001380506.1
            NM_070130.8
        SwissProt UniProtAcc Q19272
        UniProt_GCRP UniProtAcc Q19272
        OMIM gene 603382
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msh
    Allele (169)
    Legacy_information: [Kelly KO, Villeneuve AM ] me23 homozygotes viable hermaphrodite, morphologically normal; 98% of eggs fail to hatch, Him: 42% of viable progeny are male. me45 similar. Cloned: F09E8.3, homologous to budding yeast MSH5.
    Strain: WBStrain00000279
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (36)
    Paralog: WBGene00001872 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003418 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003422 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description (2)
  Disease_info: Potential_model: DOID:0111910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
      DOID:0080870 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
  Molecular_info: Corresponding_CDS: F09E8.3a
      F09E8.3b
    Corresponding_CDS_history: F09E8.3:wp37
    Corresponding_transcript: F09E8.3a.1
      F09E8.3b.1
    Other_sequence: AF070070
      TMC02651_1
      JI167893.1
      BXC01774_1
      TM03704
    Associated_feature: WBsf1018496
      WBsf229395
  Experimental_info: RNAi_result: WBRNAi00030712 Inferred_automatically: RNAi_primary
      WBRNAi00001814 Inferred_automatically: RNAi_primary
      WBRNAi00012983 Inferred_automatically: RNAi_primary
      WBRNAi00012984 Inferred_automatically: RNAi_primary
      WBRNAi00008131 Inferred_automatically: RNAi_primary
      WBRNAi00044136 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10004
      Expr1027885
      Expr1031586
      Expr1148104
      Expr2013767
      Expr2032002
    Drives_construct: WBCnstr00036128
    Construct_product: WBCnstr00036128
    Antibody: WBAntibody00002196
      WBAntibody00003031
    Microarray_results (25)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00041071:spe-44_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_enriched
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Allantoin_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:DA_DB
      WBPaper00061340:Germline
      WBPaper00061340:SMB
      WBPaper00061340:Y
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:pgl-1-wago-2
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061651:PHC_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065841:3_0
      WBPaper00065841:14_0
      WBPaper00065841:14_1
      WBPaper00065841:140_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00029437:dcr-1_downregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00035873:dpy-9_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037611:GLD-2-associated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00042178:hlh-29(tm284)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00048624:hlh-25(ok1710)_downregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (73)
  Map_info: Map: IV Position: 8.22608 Error: 0.01548
    Well_ordered
    Positive: Positive_clone: F09E8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4008
        4009
  Reference (41)
  Remark: sequence connection from [Villeneuve AM]
    Sequence connection from [Boulton S, Vidal M]
    Data extracted from Kelly et al. (2000)
    F09E8.2 removed. email from JAH 0109
    Positive_clone is based on mutant sequence [030403 ck1]
  Method: Gene