| WBGene00003386 | Evidence | Paper_evidence | WBPaper00004415 |
|---|
| SMap | S_parent | Sequence | K06C4 |
| Identity | Version | 1 |
| | Name | CGC_name | mod-1 | Person_evidence | WBPerson268 |
| | | Sequence_name | K06C4.6 |
| | | Molecular_name | K06C4.6a |
| | | | K06C4.6a.1 |
| | | | CE28590 |
| | | | K06C4.6b |
| | | | CE30814 |
| | | | K06C4.6c |
| | | | CE38391 |
| | | | K06C4.6b.1 |
| | | | K06C4.6c.1 |
| | | Other_name | CELE_K06C4.6 | Accession_evidence | NDB | BX284605 |
| | | Public_name | mod-1 |
| | DB_info | Database | AceView | gene | 5J390 |
| | | | WormQTL | gene | WBGene00003386 |
| | | | WormFlux | gene | WBGene00003386 |
| | | | NDB | locus_tag | CELE_K06C4.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003386|UniProtKB=Q9GQ00 |
| | | | | family | PTHR18945 |
| | | | NCBI | gene | 179269 |
| | | | RefSeq | protein | NM_001028863.5 |
| | | | | | NM_171495.6 |
| | | | | | NM_001028864.4 |
| | | | SwissProt | UniProtAcc | Q9GQ00 |
| | | | TREEFAM | TREEFAM_ID | TF315490 |
| | | | UniProt_GCRP | UniProtAcc | Q9GQ00 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mod |
| | Allele (72) |
| | Legacy_information | [Ranganathan R] modulation of locomotion defective. Resistant to effects of serotonin on locomotion. |
| | Strain | WBStrain00027365 |
| | | WBStrain00055584 |
| | | WBStrain00055581 |
| | | WBStrain00055576 |
| | | WBStrain00055575 |
| | | WBStrain00055061 |
| | | WBStrain00055570 |
| | | WBStrain00055580 |
| | | WBStrain00055579 |
| | RNASeq_FPKM (74) |
| | GO_annotation (37) |
| | Ortholog (29) |
| | Paralog (100) |
| | Structured_description | Concise_description | mod-1 encodes a serotonin-gated chloride channel; contrary to published literature, MOD-1 activity is NOT required for the enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; subsequent studies have shown that mod-1 mutants (n3034, ok103, nr2043) do not exhibit reduced enhanced slowing and that the behavioral defect of the original isolate and mod-1 chloride channel mutation (n3034) are genetically separable; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord. | Paper_evidence | WBPaper00004415 |
| | | | | Person_evidence | WBPerson461 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 07 Oct 2009 00:00:00 |
| | | Automated_description | Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 28 May 2019 00:00:00 |
| Models_disease_asserted | WBDOannot00000683 |
| Molecular_info | Corresponding_CDS | K06C4.6a |
| | | K06C4.6b |
| | | K06C4.6c |
| | Corresponding_transcript | K06C4.6a.1 |
| | | K06C4.6b.1 |
| | | K06C4.6c.1 |
| | Other_sequence | JI466929.1 |
| | | JI169197.1 |
| | | JI478000.1 |
| | | JI468889.1 |
| | Associated_feature | WBsf669190 |
| | | WBsf1000785 |
| | | WBsf1000786 |
| | | WBsf1020115 |
| | | WBsf1020116 |
| | | WBsf234154 |
| | | WBsf234155 |
| | | WBsf234156 |
| | | WBsf234157 |
| Experimental_info | RNAi_result | WBRNAi00034017 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00050055 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct (10) |
| | Construct_product | WBCnstr00007179 |
| | | WBCnstr00007180 |
| | | WBCnstr00015422 |
| | | WBCnstr00020388 |
| | | WBCnstr00036146 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056284:ints-6(t1903)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_OP50 |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:hypoxia_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:xbx-3-DH11.5_20397 |
| | | WBPaper00061651:AIM_enriched |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:48_0 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00065841:67_0 |
| | | WBPaper00065841:73_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065841:93_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:112_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:120_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:122_0 |
| | | WBPaper00065841:130_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00047070:N2_starvation_upregulated |
| | Interaction | WBInteraction000001399 |
| | | WBInteraction000031265 |
| | | WBInteraction000166111 |
| | | WBInteraction000520738 |
| | | WBInteraction000525285 |
| Map_info | Map | V | Position | 1.72643 | Error | 0.025158 |
| | Well_ordered |
| | Positive | Positive_clone | C38E12 |
| | | | K06C4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | C31A10 |
| | Mapping_data | Multi_point | 3874 |
| | | | 3875 |
| | | | 3876 |
| | | | 3877 |
| | | | 3878 |
| | | | 3880 |
| | | | 3881 |
| | | | 3882 |
| | | | 3883 |
| Reference (108) |
| Remark | Positive clone C38E12 is based on stable transformation rescue [030407 ck1] | Person_evidence | WBPerson1388 |
| | Negative clone C31A10 is based on failure to rescue [030407 ck1] | Person_evidence | WBPerson1388 |
| | This mod-1 (cgc4415) is different from the mod-1 published in cgc3363, which is now dmo-1 | Paper_evidence | WBPaper00004415 |
| | | | WBPaper00003363 |
| Method | Gene |
