| WBGene00003171 | SMap | S_parent | Sequence | ZK154 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mec-7 | Person_evidence | WBPerson95 |
| | | Sequence_name | ZK154.3 |
| | | Molecular_name | ZK154.3 |
| | | | ZK154.3.1 |
| | | | CE15257 |
| | | Other_name | CELE_ZK154.3 | Accession_evidence | NDB | BX284606 |
| | | Public_name | mec-7 |
| | DB_info | Database (10) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (11) |
| Disease_info | Experimental_model | DOID:14452 | Homo sapiens | Paper_evidence | WBPaper00002711 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Aug 2018 00:00:00 |
| | Potential_model | DOID:0112242 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20778) |
| | | DOID:0090136 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20778) |
| | | DOID:0112240 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20771) |
| | | DOID:0060798 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20774) |
| | | DOID:0090041 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20774) |
| | Disease_relevance | C. elegans mec-4 and deg-1 genes encode proteins, called degenerins, that are similar to the subunits of the human amiloride-sensitive epithelial sodium-channels; death-inducing substitutions in the gain-of-function mutant deg-1, e1611 and u231, may hyperactivate the channels, resulting in increased or altered ion flow and/osmotic imbalance and consequent neuron death; similarities between the degenerin-induced deaths and the early pathology of of neurons in human dominant myotonias, excitotoxicity, and epilepsy suggest similar mechanisms; studies with the elegans mutations show that the abnormalities infolding of the plasma membrane whorls, cytoplasmic vacuoles, cell swelling, chromatin aggregates and nuclear invaginations; mitochondria and golgi are not dramatically affected until the final stages of cell death when organelles, and sometimes the cells lyse; pathology of degeneration is dependent on abnormal degenerin gene dosage. | Homo sapiens | Paper_evidence | WBPaper00002711 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 13 Nov 2014 00:00:00 |
| Models_disease_asserted | WBDOannot00000609 |
| Molecular_info | Corresponding_CDS | ZK154.3 |
| | Corresponding_transcript | ZK154.3.1 |
| | Other_sequence (45) |
| | Associated_feature | WBsf654161 |
| | | WBsf654162 |
| | | WBsf977521 |
| | | WBsf977522 |
| | | WBsf977523 |
| | | WBsf977524 |
| | | WBsf1005948 |
| | | WBsf1023307 |
| | | WBsf237608 |
| Experimental_info | RNAi_result (18) |
| | Expr_pattern | Expr266 |
| | | Expr1504 |
| | | Expr1524 |
| | | Expr1577 |
| | | Expr11808 |
| | | Expr1015364 |
| | | Expr1031504 |
| | | Expr1162675 |
| | | Expr2013501 |
| | | Expr2031735 |
| | Drives_construct (154) |
| | Construct_product | WBCnstr00000678 |
| | | WBCnstr00001034 |
| | | WBCnstr00015918 |
| | | WBCnstr00036199 |
| | Antibody | WBAntibody00000087 |
| | | WBAntibody00001541 |
| | | WBAntibody00001774 |
| | | WBAntibody00001775 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00046795:starvation_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048952:glucose_induced |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:hyl-2(tm2031)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00049954:BPA_downregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057149:prgn-1(tm985)_downregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057347:nhr-14(tm1473)_downreglated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059254:CSR-1_interacting |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060908:TEBP-1_interacting |
| | | WBPaper00060908:TEBP-2_interacting |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:PLM_ALN_grandparent |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:Y |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:C25E10.11-F35H12.1 |
| | | WBPaper00061527:mtd-1-mec-18 |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:AVF_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:FLP_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062002:Day4-adult_secretome |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062167:mbl-1(tm1563)_downregulated |
| | | WBPaper00062197:TRN_enriched |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00064992:heat-shock_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:67 |
| | | WBPaper00065623:75 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:66_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_1_6 |
| | | cgc4489_group_24 |
| | | cgc4489_male_enriched_neuronal_genes |
| | | WBPaper00025032:cluster_141 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037113:CPF_16C_down-regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (229) |
| | WBProcess | WBbiopr:00000002 |
| Map_info | Map | X | Position | -1.27615 | Error | 0.00769 |
| | Well_ordered |
| | Positive | Inside_rearr | raDf7 |
| | | Positive_clone | NW#B4 |
| | | | ZK154 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 167 |
| | | | 672 |
| | | | 1828 |
| | | Multi_point (15) |
| | | Pos_neg_data | 7293 |
| | | | 7294 |
| | | | 7295 |
| | | | 529 |
| | | | 3176 |
| | | | 9433 |
| Reference (243) |
| Method | Gene |
