lpd-8 encodes a homolog of human and mouse HIRA-interacting protein-5; LPD-8 has C-terminal similarity to a domain of NifU observed in thioredoxin-like proteins and domains (COG0694), and is predicted to be mitochondrial on phylogenetic grounds.
Predicted to enable 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Involved in lipid storage. Predicted to be located in mitochondrion. Used to study multiple mitochondrial dysfunctions syndrome 1. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Is an ortholog of human NFU1 (NFU1 iron-sulfur cluster scaffold).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.