| WBGene00003020 | SMap | S_parent | Sequence | C32F10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-35 | Person_evidence | WBPerson261 |
| | | Sequence_name | C32F10.2 |
| | | Molecular_name | C32F10.2 |
| | | | C32F10.2.1 |
| | | | CE24823 |
| | | Other_name | CELE_C32F10.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lin-35 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Allele (104) |
| | Legacy_information | n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)). |
| | | See also n373, n745 |
| | | [C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS] |
| | Strain (17) |
| | Component_of_genotype | WBGenotype00000009 |
| | RNASeq_FPKM (74) |
| | GO_annotation (50) |
| | Ortholog (43) |
| | Structured_description | Concise_description | lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. | Paper_evidence | WBPaper00003329 |
| | | | | | WBPaper00004635 |
| | | | | | WBPaper00005137 |
| | | | | | WBPaper00005931 |
| | | | | | WBPaper00024215 |
| | | | | | WBPaper00024320 |
| | | | | | WBPaper00024322 |
| | | | | | WBPaper00024692 |
| | | | | | WBPaper00027135 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 05 May 2009 00:00:00 |
| | | Automated_description | Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00024322 |
| | | | | Accession_evidence | OMIM | 309580 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Apr 2013 00:00:00 |
| | Potential_model (16) |
| | Disease_relevance | Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. | Homo sapiens | Paper_evidence | WBPaper00024322 |
| | | | | | WBPaper00024692 |
| | | | | | WBPaper00003646 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 23 Apr 2013 00:00:00 |
| Models_disease_asserted | WBDOannot00000614 |
| | WBDOannot00001021 |
| Molecular_info | Corresponding_CDS | C32F10.2 |
| | Corresponding_transcript | C32F10.2.1 |
| | Associated_feature | WBsf643315 |
| | | WBsf643316 |
| | | WBsf656335 |
| | | WBsf656336 |
| | | WBsf656337 |
| | | WBsf656338 |
| | | WBsf983774 |
| | | WBsf217712 |
| | Gene_product_binds (376) |
| | Transcription_factor | WBTranscriptionFactor000270 |
| Experimental_info | RNAi_result (78) |
| | Expr_pattern | Chronogram622 |
| | | Expr1291 |
| | | Expr3128 |
| | | Expr1015789 |
| | | Expr1031411 |
| | | Expr1145718 |
| | | Expr2013177 |
| | | Expr2031409 |
| | Drives_construct | WBCnstr00004066 |
| | | WBCnstr00006281 |
| | | WBCnstr00011156 |
| | | WBCnstr00017294 |
| | | WBCnstr00036281 |
| | Construct_product | WBCnstr00006281 |
| | | WBCnstr00011156 |
| | | WBCnstr00017287 |
| | | WBCnstr00017294 |
| | | WBCnstr00017295 |
| | | WBCnstr00017296 |
| | | WBCnstr00021077 |
| | | WBCnstr00021078 |
| | | WBCnstr00021079 |
| | | WBCnstr00036281 |
| | Regulate_expr_cluster (16) |
| | Antibody | WBAntibody00000200 |
| | | WBAntibody00001176 |
| | | WBAntibody00003008 |
| | | WBAntibody00003009 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:down_in_lin-35 |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060886:spr-5(by101)_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:Ciliated_amphid_neuron |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Excretory_cell_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:Neuroblast_AIZ_FLP_RMG |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:cyy-1_3136-hcf-1_2478 |
| | | WBPaper00061527:npp-6-mtr-4_21425 |
| | | WBPaper00062056:dpl-1(n2994)_upregulated |
| | | WBPaper00062056:efl-1(se1)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(n766)_upregulated |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062056:lin-37(n758)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_1 |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_197 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_26 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (322) |
| | Product_binds_matrix | WBPmat00005534 |
| | | WBPmat00005535 |
| | | WBPmat00005536 |
| | | WBPmat00005540 |
| | | WBPmat00005541 |
| | | WBPmat00005542 |
| | | WBPmat00005543 |
| | | WBPmat00005544 |
| | | WBPmat00005545 |
| Map_info | Map | I | Position | 0.461719 | Error | 0.000997 |
| | Well_ordered |
| | Positive | Positive_clone | C32F10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point (4) |
| Reference (253) |
| Picture | WBPicture0000013091 |
| Method | Gene |
