| WBGene00001808 | Evidence | Person_evidence | WBPerson1846 |
|---|
| SMap | S_parent | Sequence | T10G3 |
| Identity | Version | 1 |
| | Name | CGC_name | gut-2 | Person_evidence | WBPerson579 |
| | | Sequence_name | T10G3.6 |
| | | Molecular_name | T10G3.6a |
| | | | T10G3.6a.1 |
| | | | CE37990 |
| | | | T10G3.6b |
| | | | CE45330 |
| | | | T10G3.6b.1 |
| | | Other_name | lsm-2 | CGC_data_submission |
| | | | CELE_T10G3.6 | Accession_evidence | NDB | BX284605 |
| | | Public_name | gut-2 |
| | DB_info | Database | AceView | gene | 5N979 |
| | | | WormQTL | gene | WBGene00001808 |
| | | | WormFlux | gene | WBGene00001808 |
| | | | NDB | locus_tag | CELE_T10G3.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001808|UniProtKB=P92022 |
| | | | | family | PTHR13829 |
| | | | NCBI | gene | 179833 |
| | | | RefSeq | protein | NM_001269582.2 |
| | | | | | NM_001269583.3 |
| | | | TREEFAM | TREEFAM_ID | TF314960 |
| | | | TrEMBL | UniProtAcc | P92022 |
| | | | | | E1B6V1 |
| | | | UniProt_GCRP | UniProtAcc | P92022 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gut |
| | Allele (31) |
| | Legacy_information | [C.elegansII] lw6 : E cells fail to gastrulate, division rate does not slow; mutant EMS not responsive to WT P2 induction. lw6/Df similar. OA>10: it92, lw63 (Gro, sterile). Cloned: cosmid rescue (T10G8). [EH; CB] |
| | | [Shaw JE] lw6 and it92 are not null alleles. lw6 and it92 are recessive, strict maternal effect lethal. Dead embryos arrest development with approximately normal cell number but no morphogenesis. Dead embryos are highly penetrant for lack of both differentiated gut cells and pharyngeal muscle. Other tissues (hypodermal, neuronal, body-wall muscle) are present. Early defects in E lineage,i.e. early 2E to 4E division and failure to gastrulate, highly penetrant. Null phenotype likely recessive slow-growing, sterile adult. |
| | Strain | WBStrain00036163 |
| | | WBStrain00036228 |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (33) |
| | Structured_description | Concise_description | gut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability. | Paper_evidence | WBPaper00012624 |
| | | | | | WBPaper00023072 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in P-body. Predicted to be part of Lsm1-7-Pat1 complex and ribonucleoprotein complex. Is an ortholog of human LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T10G3.6a |
| | | T10G3.6b |
| | Corresponding_CDS_history | T10G3.6:wp138 |
| | Corresponding_transcript | T10G3.6a.1 |
| | | T10G3.6b.1 |
| | Other_sequence (54) |
| | Associated_feature | WBsf647462 |
| | | WBsf662028 |
| | | WBsf232784 |
| Experimental_info | RNAi_result (28) |
| | Expr_pattern | Expr1016964 |
| | | Expr1031059 |
| | | Expr1156677 |
| | | Expr2012349 |
| | | Expr2030585 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_downregulated_cDNA_12h |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_downregulated |
| | | WBPaper00038118:stress_downregulated_N2 |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045729:gld-4(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_WT_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061045:Y56A3A.22(cck200)_downregulated |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:R07E4.5-skp-1_1608 |
| | | WBPaper00061572:oleic-acid-specific_mating_upregulated |
| | | WBPaper00061651:Germline_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00062715:blmp-1(s71)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065841:38_0 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (330) |
| Map_info | Map | V | Position | 5.35258 | Error | 0.004597 |
| | Well_ordered |
| | Positive | Positive_clone | K10B8 |
| | | | T10G3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | R11G10 |
| | Mapping_data (2) |
| Reference | WBPaper00012624 |
| | WBPaper00014687 |
| | WBPaper00015015 |
| | WBPaper00021955 |
| | WBPaper00022720 |
| | WBPaper00023072 |
| | WBPaper00038491 |
| | WBPaper00046572 |
| | WBPaper00055090 |
| | WBPaper00059527 |
| Remark | The gut-2 gene was merged with lsm-2 following advice from the CGC. gut-2 is the main name for this gene. | CGC_data_submission |
| Method | Gene |
