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WormBase Tree Display for Gene: WBGene00001535

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Name Class

WBGene00001535SMapS_parentSequenceC49H3
IdentityVersion1
NameCGC_namegcy-8Person_evidenceWBPerson655
Sequence_nameC49H3.1
Molecular_nameC49H3.1
C49H3.1.1
CE42080
Other_nameCELE_C49H3.1Accession_evidenceNDBBX284604
Public_namegcy-8
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgcy
Allele (54)
Legacy_information[Yu S] gcy for Guanylyl CYclase. No mutations known. gcy-8::GFP expressed only in AFD. Predicted gene C49H3.2
Strain (5)
RNASeq_FPKM (74)
GO_annotation (38)
Ortholog (35)
Paralog (37)
Structured_descriptionConcise_descriptiongcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1.Paper_evidenceWBPaper00002839
WBPaper00004879
WBPaper00006343
WBPaper00027040
Curator_confirmedWBPerson1843
Date_last_updated07 Aug 2006 00:00:00
Automated_descriptionEnables guanylate cyclase activity. Involved in microvillus organization and response to temperature stimulus. Located in microvillus membrane and neuron projection terminus. Expressed in AFDL and AFDR.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC49H3.1
Corresponding_CDS_historyC49H3.1:wp187
Corresponding_transcriptC49H3.1.1
Other_sequence (14)
Associated_featureWBsf646129
WBsf980902
WBsf980903
WBsf228598
Experimental_infoRNAi_resultWBRNAi00042833Inferred_automaticallyRNAi_primary
WBRNAi00012164Inferred_automaticallyRNAi_primary
WBRNAi00103221Inferred_automaticallyRNAi_primary
WBRNAi00012161Inferred_automaticallyRNAi_primary
WBRNAi00029995Inferred_automaticallyRNAi_primary
WBRNAi00042832Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_construct (41)
Construct_productWBCnstr00011696
WBCnstr00018503
WBCnstr00036879
Microarray_results (21)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00044037:eat-2_upregulated
WBPaper00045390:tunicamycin_downregulated
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00046805:csr-1(RNAi)_upregulated_Set2
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049377:MWCNT_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
WBPaper00053771:up_at_3h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00056161:hermaphrodite_enriched_siRNA
WBPaper00056284:ints-6(t1903)_upregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AFD
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061527:ckr-1-T09B9.3
WBPaper00061651:AFD_enriched
WBPaper00061818:AFD_enriched_protein
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062056:lin-37(n758)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064789:Day6_vs_Day1_upregulated_neuron
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064789:Day12_vs_Day1_upregulated_neuron
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065158:AFD_enriched
WBPaper00065841:35_0
WBPaper00066110:Doxorubicin_upregulated_tetraploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00024671:AFD_vs_AWB_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00034661:AgNPs_downregulated
WBPaper00034739:N2moreDR1350
WBPaper00036123:Cadmium_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00037113:Diazinon_16C_regulated
WBPaper00039866:ClassComp_daf-19_downregulated
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00048637:lin-35(n745)_starvation_downregulated
WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
Interaction (30)
Map_infoMapIVPosition3.50015Error0.000609
PositivePositive_cloneC49H3Person_evidenceWBPerson4049
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4941
Pseudo_map_position
Reference (72)
RemarkData extracted from Yu et al. (1997)
C49H3.2 is dead merged into .1 [sdm 11.2000]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene