WormBase Tree Display for Gene: WBGene00001515

WBGene00001515 SMap: S_parent: Sequence: T24C12
  Identity: Version: 2
    Name: CGC_name: gap-1 Person_evidence: WBPerson1160
      Sequence_name: T24C12.2
      Molecular_name (3)
      Other_name: suv-1 Paper_evidence: WBPaper00002916
        sli-5 Paper_evidence: WBPaper00028495
          Person_evidence: WBPerson625
        CELE_T24C12.2 Accession_evidence: NDB BX284606
      Public_name: gap-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Oct 2006 10:47:33 WBPerson2970 Name_change: Other_name: sli-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gap
    Allele (46)
    Legacy_information: [C.elegansII] n1329 : suppresses vulvaless phenotype of lin-10(n1390); complex suppressive or enhancing interactions with other vulva determination genes; no phenotype alone. OA11. [MT]
    Strain: WBStrain00030706
      WBStrain00030712
      WBStrain00000139
      WBStrain00000145
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (46)
    Paralog: WBGene00001516 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: gap-1 encodes a member of the Ras GTPase-activating protein family; negatively regulates the let-60 pathway with respect to vulval development. Paper_evidence: WBPaper00001366
            WBPaper00002916
            WBPaper00003429
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable GTPase activator activity. Involved in chemosensory behavior; learning or memory; and negative regulation of Ras protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Noonan syndrome. Is an ortholog of human RASA3 (RAS p21 protein activator 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3490 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9872)
  Molecular_info: Corresponding_CDS: T24C12.2
    Corresponding_transcript: T24C12.2.1
    Other_sequence: CSC01349_1
      GO250797.1
      FD516661.1
      Dviv_isotig15222
      DAC01481_1
      DA00174
      CBC10547_1
    Associated_feature: WBsf647845
      WBsf718517
  Experimental_info: RNAi_result: WBRNAi00054029 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025718
      Expr1030911
      Expr1157569
      Expr2011941
      Expr2030178
    Drives_construct: WBCnstr00036895
    Construct_product: WBCnstr00036895
    Microarray_results (19)
    Expression_cluster: WBPaper00032528:L3_depleted
      WBPaper00035211:age-1_vs_age-1_downregulated
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040412:germline-regulated_daf-12_target
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045401:N.parisii_64h_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055226:ADR-2_target_adr-1(tm668)
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVG
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:tub-2_4713-daf-2_5288
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064473:ets-4(rrr16)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065841:29_0
      WBPaper00065841:59_0
      WBPaper00065841:94_0
      WBPaper00065841:135_0
      WBPaper00065841:144_0
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
    Interaction (95)
    WBProcess: WBbiopr:00000071
  Map_info: Map: X Position: -16.8866 Error: 0.078365
    Well_ordered
    Positive: Positive_clone: T24C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1772
        1773
        1777
        1778
        1779
        1780
  Reference (60)
  Method: Gene