WormBase Tree Display for Gene: WBGene00001478

WBGene00001478 SMap: S_parent: Sequence: Y39A1A
  Identity: Version: 2
    Name: CGC_name: fmo-3
      Sequence_name: Y39A1A.19
      Molecular_name: Y39A1A.19a
        Y39A1A.19a.1
        CE19139
        Y39A1A.19b
        CE52017
        Y39A1A.19b.1
        Y39A1A.19b.2
        Y39A1A.19b.3
      Other_name: fmo-13 Person_evidence: WBPerson3011
        CELE_Y39A1A.19 Accession_evidence: NDB BX284603
      Public_name: fmo-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Sep 2004 14:56:48 WBPerson1971 Name_change: CGC_name: fmo-13 -> fmo-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fmo
    Allele (83)
    Strain: WBStrain00003299
      WBStrain00031424
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (68)
    Paralog: WBGene00001476 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001477 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001480 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001479 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007254 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016728 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: fmo-3 encodes a flavin-containing monoxygenase homologous to human FMO1, FMO2, and FMO3 (OMIM:602079, mutated in trimethylaminuria). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 May 2007 00:00:00
      Automated_description: Predicted to enable monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension and trimethylaminuria. Is an ortholog of several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080361 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3771)
      DOID:655 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3771)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3771)
  Molecular_info: Corresponding_CDS: Y39A1A.19a
      Y39A1A.19b
    Corresponding_transcript: Y39A1A.19a.1
      Y39A1A.19b.1
      Y39A1A.19b.2
      Y39A1A.19b.3
    Other_sequence (22)
    Associated_feature: WBsf645576
      WBsf994119
      WBsf994120
      WBsf225749
      WBsf225750
  Experimental_info: RNAi_result: WBRNAi00061321 Inferred_automatically: RNAi_primary
      WBRNAi00056103 Inferred_automatically: RNAi_primary
      WBRNAi00001292 Inferred_automatically: RNAi_primary
      WBRNAi00006898 Inferred_automatically: RNAi_primary
      WBRNAi00006965 Inferred_automatically: RNAi_primary
      WBRNAi00056102 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3220
      Expr6942
      Expr1015071
      Expr1030881
      Expr1159623
      Expr2011858
      Expr2030096
    Drives_construct: WBCnstr00003770
      WBCnstr00011231
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045774:clk-1_upregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048988:neuron_expressed
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053140:IncreasingResponse_20nmAgCit
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056284:ints-11(RNAi)_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058927:high-redox-state_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061081:skpo-1(ok1640)_downregulated_OG1RF
      WBPaper00061081:skpo-1(ok1640)_downregulated_OP50
      WBPaper00061340:g2
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:col-128-cdh-10_9234
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062335:sir-2.1(ok434)_upregulated_L3
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064156:lipl-4(overexpress)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064375:sid-1(pk3321)_regulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064661:lpd-3(ok2138)_downregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00065158:AFD_depleted
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:2_0
      WBPaper00065841:33_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035560:ahr-1_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1up_daf-2up
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (14)
  Map_info (4)
  Reference: WBPaper00025133
    WBPaper00038491
    WBPaper00052994
    WBPaper00055090
    WBPaper00061133
    WBPaper00064375
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    This gene has been renamed with approval of the CGC (fmo-13->fmo-3) Person_evidence: WBPerson3011
  Method: Gene