| WBGene00001137 | SMap | S_parent | Sequence | B0365 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | eat-6 | Person_evidence | WBPerson32 |
| | | Sequence_name | B0365.3 |
| | | Molecular_name | B0365.3 |
| | | | B0365.3.1 |
| | | | CE07721 |
| | | | B0365.3.2 |
| | | Other_name | NaK/1 |
| | | | spa-1 |
| | | | CELE_B0365.3 | Accession_evidence | NDB | BX284605 |
| | | Public_name | eat-6 |
| | DB_info | Database | AceView | gene | 5N608 |
| | | | WormQTL | gene | WBGene00001137 |
| | | | WormFlux | gene | WBGene00001137 |
| | | | NDB | locus_tag | CELE_B0365.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001137|UniProtKB=P90735 |
| | | | | family | PTHR43294 |
| | | | NCBI | gene | 179796 |
| | | | RefSeq | protein | NM_073868.6 |
| | | | TrEMBL | UniProtAcc | P90735 |
| | | | UniProt_GCRP | UniProtAcc | P90735 |
| | | | OMIM | gene | 182310 |
| | | | | | 182340 |
| | | | | | 182350 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | eat |
| | Allele (46) |
| | Legacy_information | [Leon Avery] Strong relaxation-defective. Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms. |
| | | See also ad601, ad792 |
| | | [C.elegansII] ad467 : strong relaxation-defective.Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms. Hypersensitive to inhibitors of Na/K ATPase. Synthetic lethal with eat-11(ad541).OA2: ad601xri, ad792. Cloned: encodes alpha subunit of Na/K ATPase (pka spa-1). [Avery 1993; DA] |
| | Strain | WBStrain00036106 |
| | | WBStrain00037778 |
| | | WBStrain00005464 |
| | | WBStrain00005489 |
| | | WBStrain00005507 |
| | | WBStrain00005516 |
| | | WBStrain00005529 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (46) |
| | Paralog (14) |
| | Structured_description | Concise_description | eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. | Paper_evidence | WBPaper00001709 |
| | | | | | WBPaper00002371 |
| | | | | | WBPaper00003150 |
| | | | | | WBPaper00003257 |
| | | | | | WBPaper00003521 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson363 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 06 Jun 2019 00:00:00 |
| | Potential_model (12) |
| Models_disease_asserted | WBDOannot00000704 |
| Molecular_info | Corresponding_CDS | B0365.3 |
| | Corresponding_transcript | B0365.3.1 |
| | | B0365.3.2 |
| | Other_sequence (276) |
| | Associated_feature (18) |
| Experimental_info | RNAi_result (34) |
| | Expr_pattern | Expr8226 |
| | | Expr8228 |
| | | Expr12845 |
| | | Expr1017676 |
| | | Expr1030726 |
| | | Expr1143152 |
| | | Expr2011160 |
| | | Expr2029396 |
| | Drives_construct | WBCnstr00013194 |
| | | WBCnstr00022897 |
| | | WBCnstr00037068 |
| | Construct_product | WBCnstr00013192 |
| | | WBCnstr00037068 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00028451:Abundant_spermatogenesis_enriched |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00040965:top50_lipid-droplet_associated_protein |
| | | WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045486:starvation_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059174:PGL-1_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:MC |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061527:gpb-1_3783-C48A7.2_22459 |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:CEPsh_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:M3_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:SAB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VD_DD_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064257:UNG-1_interacting |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00066085:hda-3(ok1991)_downregulated |
| | | cgc4386_cluster_3_5 |
| | | cgc4489_group_3 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_27 |
| | | WBPaper00025032:cluster_41 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_3 |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00039835:ifg-1_upregulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (116) |
| Map_info (4) |
| Reference (55) |
| Remark | [MW Davis] Transformation rescue. |
| Method | Gene |
